Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment
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Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment
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Author : Katherine Chiappinelli
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-16
Genetic And Epigenetic Control On Immune Responses Regulating Molecules In Cancer Development Progression And Treatment written by Katherine Chiappinelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-16 with Medical categories.
In line with recent evidence, the development of cancer has been described as uncontrolled cell growth that results from gradual accumulation of genetic and epigenetic alterations, involving aberrations in oncogenes, tumor suppressor genes, and defects in genes engaged in DNA repair. As a result, cancer cells acquire a neoplastic phenotype and tumor-associated antigens (TAAs) are presented on their surface. These target structures should be recognized by cells of the immune system. However, a sequence of events at the genetic and epigenetic level disturb immune cells, and in consequence, make them unable to eliminate cancer cells. Both innate and adaptive immunity are mobilized against cancer cells. In response to the appearance of cells with malignant transformation, NK cells release perforin and granzyme, causing direct cytolysis of the target cells. They can also secrete pro-inflammatory cytokines and in that way enhance the anticancer response. The activity of NK cells is regulated by a variety of activating and inhibitory receptors including NKG2D, KIR, CD94 -NKG2 heterodimers and natural cytotoxicity receptors, TNF family ligands, as well as co-stimulatory receptors, which recognize related molecules on target cells. A fundamental trigger of the anticancer immune response is the recognition of TAAs by T cells, via the major histocompatibility complex (MHC), which should be followed by signals from co-stimulatory molecules. Full activation of T lymphocytes requires a third signal provided by the presence of cytokines, and this leads to cell proliferation, differentiation, and secretion of chemokines and cytokines. The effect is to drive the clonal expansion of the T cells directed against TAAs and to recruit other immune effector cells in order to enhance immune defense.
Epigenetic Mechanisms Of Gene Regulation
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Author : Vincenzo E. A. Russo
language : en
Publisher:
Release Date : 1996
Epigenetic Mechanisms Of Gene Regulation written by Vincenzo E. A. Russo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.
Genetics And Epigenetics Of Genitourinary Diseases
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Author : Seyed Mohammad Kazem Aghamir
language : en
Publisher: Elsevier
Release Date : 2024-08-27
Genetics And Epigenetics Of Genitourinary Diseases written by Seyed Mohammad Kazem Aghamir and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-27 with Science categories.
Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students.This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers.This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample.This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field. - Provides a unique collection of genetics and epigenetics in genitourinary - Covers the subject of genetic and epigenetics in urological malignancies, infertility, and urolithiasis - Gives novel insights into genitourinary diseases even the rare ones and sheds light on genitourinary diseases from DNA methylation to CIN
Successful Drug Discovery Volume 2
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Author : János Fischer
language : en
Publisher: John Wiley & Sons
Release Date : 2016-11-04
Successful Drug Discovery Volume 2 written by János Fischer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-04 with Medical categories.
Retaining the successful approach found in the previous volume in this series, the inventors and primary developers of drugs that successfully made it to market tell the story of the drug's discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. 11 selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of the current drug development efforts. Backed by copious data and chemical information, the insight and experience of the contributors makes this one of the most useful training manuals that a junior medicinal chemist can hope to find and has won the support and endorsement of IUPAC.
Advancements In Oral Cancer Modern Diagnostics Altered Molecular Profile And Therapeutic Strategies
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2025-07-16
Advancements In Oral Cancer Modern Diagnostics Altered Molecular Profile And Therapeutic Strategies written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-16 with Medical categories.
This compelling volume examines the evolving landscape of oral cancer research and treatment, providing critical insights into cutting-edge diagnostics, molecular alterations, and therapeutic advancements. With contributions from leading researchers and clinicians, the book presents a comprehensive, multidisciplinary perspective on oral oncology. Key chapters examine the role of salivary epigenetic biomarkers in early detection, the molecular reprogramming of histologically normal tissues adjacent to tumors, and the profound impact of cancer-associated fibroblasts on treatment response. The volume also explores the latest advancements in advanced radiotherapy techniques, including Intensity-Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT), and evaluates outcomes and side effects with a focus on personalized treatment strategies. Importantly, the book addresses the microbial dysbiosis that arises after radiation therapy and its implications for the progression of oral cancer and patient quality of life. Whether you are a clinician, researcher, or healthcare professional, this volume serves as a valuable resource for understanding the molecular intricacies and therapeutic complexities of oral cancer. The book reflects the latest scientific advancements and underscores the importance of precision medicine and interdisciplinary collaboration in improving clinical outcomes for patients worldwide.
Current Trends In The Diagnosis And Management Of Metabolic Disorders
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Author : Seth Kwabena Amponsah
language : en
Publisher: CRC Press
Release Date : 2023-12-14
Current Trends In The Diagnosis And Management Of Metabolic Disorders written by Seth Kwabena Amponsah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-14 with Medical categories.
This volume provides an overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies. Metabolic disorders occur when metabolic processes in the body are disrupted. They contribute a significant burden to human health globally. They can be congenital or acquired, for example, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, osteopenia, mild-moderate hypovitaminosis D, erectile dysfunction, dyslipidemia, and thyroiditis. Metabolic disorders have gained significant importance due to the exponential increase in obesity worldwide. Early diagnosis of metabolic disorders is important in order to employ lifestyle and risk factor modification. Features: An overview of the biochemical basis of metabolic diseases and molecular basis of chemical pathologies Describes recent trends in diagnosis of metabolic disorders Discusses management and treatment of metabolic diseases Allows quick identification and retrieval of material by researchers learning the efficacy, associated dosage and toxicity of each of the classes of compounds Suitable globally for graduate and postgraduate students studying metabolic diseases
Handbook Of Epigenetics
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Author : Trygve Tollefsbol
language : en
Publisher: Academic Press
Release Date : 2010-11-21
Handbook Of Epigenetics written by Trygve Tollefsbol and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-21 with Science categories.
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
Cancer Pathogenesis Molecular And Cellular Mechanisms Of Tumor Evolution Therapy Resistance And Immune Evasion
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Author : Sambhavi Animesh
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-24
Cancer Pathogenesis Molecular And Cellular Mechanisms Of Tumor Evolution Therapy Resistance And Immune Evasion written by Sambhavi Animesh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-24 with Science categories.
Cancer pathogenesis is a pathophysiological understanding of how molecular and cellular events play a causal role in transforming tumors from benign to malignant state. This often involves genetic, epigenetic, proteomic and metabolic alterations within solid tumors and blood cells. Besides cell intrinsic factors, tumors are also composed of stromal fibroblasts, blood vessel and immune cells that are also implicated in tumor progression. Immune evasion is another critical step of the cancer progression, wherein tumor cells modulate host immune system to escape from getting destroyed. Additionally, stemness in cancer cells is another acquired intrinsic ability of self-renewal, differentiation, heterogeneity and survival. Such properties give an edge to the tumors to maintain malignancy and confers treatment resistance. Most anti-cancer therapies that trigger cell death, senescence and/or dormancy and may backfire into maladaptive responses that lead to therapy resistance and promote tumor progression. Together these highlight the most challenging issues of cancer pathogenesis. This Research Topic aims to summarize the cutting-edge research for the broader understanding of the molecular and cellular determinants involved in cancer initiation and progression, and their impact on the anti-tumor therapies and immune evasion. In summary, this topic will help researchers to gain a more comprehensive understanding of the cancer pathogenesis, which can be used further in the development of novel therapies.
Pathobiology Of Human Disease
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Author :
language : en
Publisher: Elsevier
Release Date : 2014-08-01
Pathobiology Of Human Disease written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-01 with Science categories.
Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human - Organ Systems - Molecular Pathology/Basic Mechanisms of Diseases - Animal Models/Other Model Systems - Experimental Pathology - Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. - Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting - Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images - Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions
Personalized Medicine In Neuroscience Molecular To System Approach
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Author : Ali Yadollahpour
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-17
Personalized Medicine In Neuroscience Molecular To System Approach written by Ali Yadollahpour and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-17 with Science categories.
Personalized or precision medicine (PM) is developing and adopting of the safest and most cost-effective therapeutic approach for each patient. PM approach aims to identify phenotypic and genotypic individual characteristics, observe how these parameters are correlated with the disease status, severity, and intervention responsiveness to predict the best personalized clinical protocol. On the other hand, the risk of severe toxicity and adverse effects might be related to the patient-specific characteristics.