Genetic Complementation
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Genetic Complementation
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Author : J. R. S. Fincham
language : en
Publisher:
Release Date : 1966
Genetic Complementation written by J. R. S. Fincham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1966 with Complementation (Genetics). categories.
Genetic systems for the study of complementation; From the gene to the cistron; Equivocal cistrons; The mechanism of interallelic complementation; Complementation maps and their interpretation; The possible evolutionary significance of allelic complementation.
Genetic Complementation Of A Mammalian Cell Cycle Mutant
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Author : Gordon John Sauvé
language : en
Publisher:
Release Date : 1986
Genetic Complementation Of A Mammalian Cell Cycle Mutant written by Gordon John Sauvé and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with categories.
Directed Enzyme Evolution
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Author : Frances H. Arnold
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Directed Enzyme Evolution written by Frances H. Arnold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum “you get what you screen for. ” The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.
The Chromosome Complement
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Author : Bernard John
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Chromosome Complement written by Bernard John and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
material can serve both autocatalytic and heterocatalytic functions. Thus not only is it unique in itB capacity for self-replication but its base sequence determines the specificity of proteins. And enzyme proteins are immediately responsible for the peripheral metabolism which enables the organism to impose its own kind of order on the raw materials it absorbs. The course of development is determined not only by the nature of the genetic material but by its over-all amount and the relative frequency of the different functional units. Differential rates of epigenetic activity matter also. In theory, therefore, differential development within or even between individuals could be determined by the differential replication of the various genetic elements or by their differential activity. And further variation could arise by the differential transmission of these elements between cells. Indeed it would appear that all these possibilities are exploited by living systems. If like is to beget like, however, any genetic change which occurs during development must be undone, or else germinal units preserved from change must be set aside. As far as is known, genetic changes, even those involving only quantity or relative amounts, are reversible to only a very limited extent so that a change once done cannot be undone. Consequently genetic changes during the development of presumptive germ-lines are either non existant or minor and confined to a small class of un aggregated deter minants.
Trends In Genetic Analysis
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Author : G. Pontecorvo
language : en
Publisher:
Release Date : 1958
Trends In Genetic Analysis written by G. Pontecorvo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1958 with Science categories.
Graphs And Genes
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Author : B.G. Mirkin
language : en
Publisher: Springer
Release Date : 2011-11-08
Graphs And Genes written by B.G. Mirkin and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-08 with Mathematics categories.
This book is written by a mathematician and a theoretical biologist who have arrived at a good mutual understanding and a well worked-out common notation. The reader need hardly be convinced of the necessity of such a mutual understanding, not only for the two investigators, but also for the sciences they represent. Like Moliere's hero, geneticists are gradually beginning to understand that, unknowingly, they have been speaking in the language of cybernetics. Mathematicians are unexpec tedly discovering that many past and present problems and methods of genetics can be naturally formulated in the language of graph theory. In this way a powerful abstract mathematical theory suddenly finds a productive application. Moreover, in its turn, such an application be gins to "feed" the mathematical theory by presenting it with a number of new problems. The reader may judge for himself the fruitfulness of such mutual interaction. At the same time several important circumstances need to be men tioned. The formalization and rigorous formulation given here embraces not only the older problems, known by geneticists for many decades (the construction of genetic maps, the analysis of complementation, etc. ), but also comparatively new problems: the construction of partial com plementation maps, phylogenetic trees of proteins, etc.
The Complement Factsbook
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Author : Scott R. Barnum
language : en
Publisher: Academic Press
Release Date : 1999-10-28
The Complement Factsbook written by Scott R. Barnum and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-28 with Medical categories.
The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references
Genetics
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Author : Daniel L. Hartl
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2009
Genetics written by Daniel L. Hartl and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This handbook covers all dimensions of breast cancer prevention, diagnosis, and treatment for the non-oncologist. A special emphasis is placed on the long term survivor.
Advanced Genetic Analysis
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Author : R. Scott Hawley
language : en
Publisher: John Wiley & Sons
Release Date : 2009-05-06
Advanced Genetic Analysis written by R. Scott Hawley and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-06 with Science categories.
Advanced Genetic Analysis brings a state-of-the-art,exciting new approach to genetic analysis. Focusing on theunderlying principles of modern genetic analysis, this bookprovides the 'how' and 'why' of the essential analytical toolsneeded. The author's vibrant, accessible style provides an easyguide to difficult genetic concepts, from mutation and genefunction to gene mapping and chromosome segregation. Throughout, abalanced range of model organisms and timely examples are used toillustrate the theoretical basics. Basic principles - Focuses students attention on the 'how' and'why' of the essential analytical tools. Vibrant, accessible style provides an easy guide throughdifficult genetic concepts and techniques. Text boxes highlight key questions and timely examples. Boxes of key information in each chapter, chapter summaries andextensive references - prompt the student to synthesise andreinforce the chapter material. Special reference section addressing a range of model organismsto help provide a particularly relevant context for students'research interests.
Genetics For Surgeons
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Author : Patrick John Morrison
language : en
Publisher: Remedica
Release Date : 2005
Genetics For Surgeons written by Patrick John Morrison and has been published by Remedica this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com).