Genetic Determinants Of Peak Bone Mineral Density
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Genetic Determinants Of Peak Bone Mineral Density
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Author : Brasen
language : en
Publisher:
Release Date : 2010
Genetic Determinants Of Peak Bone Mineral Density written by Brasen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Genetic Determinants Of Peak Bone Mineral Density
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Author : Claus Lohman Brasen
language : en
Publisher:
Release Date : 2010
Genetic Determinants Of Peak Bone Mineral Density written by Claus Lohman Brasen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Bone Health And Osteoporosis
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Author : United States Public Health Service
language : en
Publisher:
Release Date : 2004-12
Bone Health And Osteoporosis written by United States Public Health Service and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12 with Health & Fitness categories.
This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
Genetic Determinants Of Bone Mineral Density And Osteoporosis
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Author : John Peter Kemp
language : en
Publisher:
Release Date : 2013
Genetic Determinants Of Bone Mineral Density And Osteoporosis written by John Peter Kemp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The Aging Skeleton
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Author : Clifford Rosen
language : en
Publisher: Elsevier
Release Date : 1999-08-19
The Aging Skeleton written by Clifford Rosen and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-19 with Medical categories.
The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. Covers all aspects of the aging skeleton in one comprehensive volume Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton Reviews current therapeutic approaches and methods Written by internationally renowned authors and edited by leaders in the field Is the only book available on this subject
Osteoporosis In Men
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Author : Eric S. Orwoll
language : en
Publisher: Academic Press
Release Date : 2009-11-30
Osteoporosis In Men written by Eric S. Orwoll and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-30 with Medical categories.
Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy There is no book on the market that covers osteoporosis in men as comprehensively as this book
Practical Pediatric Endocrinology In A Limited Resource Setting
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Author : Margaret Zacharin
language : en
Publisher: Academic Press
Release Date : 2013-04-11
Practical Pediatric Endocrinology In A Limited Resource Setting written by Margaret Zacharin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-11 with Medical categories.
Practical Pediatric Endocrinology in a Limited Resource Setting provides a guide for managing pediatric endocrine problems in a limited resource setting, together with an outline of the bases for these disorders. The book outlines a plan for coming to a likely diagnosis in situations where resources are constrained, and suggests ways to access more sophisticated technologies for diagnostic confirmation and extension of available tools. Further extending and complementing each chapter is a series of scenarios for use as teaching and learning tools. Together with a clinical question, all chapters include a suggested outline for assessment that assists readers facing similar situations in daily practice. Each scenario works through a typical series of deductive steps used to establish a working diagnosis, while considering both a differential diagnosis and reminding readers of current knowledge around the subject matter. Provides a working knowledge of pediatric endocrinology, from the viewpoint of practical application, for residents and clinicians practicing in settings with scarce material resources Features clinically based chapters, empahsising workable diagnoses and management plans in limited resource situations Includes information on Type 1 diabetes mellitus, given its increasing prevalence worldwide Describes basic research techniques and planning, intended to foster collaboration between colleagues and other centers in clinical or basic research, which can inform clinical practice and drive innovation
Osteoporosis
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Author : Benjamin Z. Leder
language : en
Publisher: Springer Nature
Release Date : 2020-01-31
Osteoporosis written by Benjamin Z. Leder and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-31 with Medical categories.
Completely revised and updated, and utilizing the most current evidence and practice guidelines for the treatment of osteoporosis, this comprehensive third edition discusses the basic aspects of bone metabolism, the pathophysiology of osteoporosis, current diagnostic techniques and medical treatment strategies. Osteoporosis is a common disorder that is prevalent in over 20 million Americans over the age of 60. One and a half million osteoporotic fractures occur in the United States every year, including 300,000 hip fractures. Mortality rates after hip fracture approach 25%, with another 50% of patients experiencing a major decrease in their prior level of independence and quality of life. Despite the wide prevalence and severe consequences of osteoporosis, it remains a disorder that is severely under-diagnosed and treated. In this context, specialists and primary care physicians alike are having increasing difficulty keeping up with the rapid changes to the field and incorporating these advances to clinical care. In the years since the last edition of this book was published, the osteoporosis field has changed drastically. In addition to revising and updating existing chapters and removing a few that are no longer as relevant, new chapters discuss an advanced understanding of the cellular and molecular mechanisms underlying the disorder, the introduction of new diagnostic imaging techniques, a more nuanced appreciation of the risks and benefits of osteoporosis therapies, and the introduction of two new classes of osteoporosis medications. Following the format of the second edition, and including helpful key points at the opening of each chapter, this text will present a comprehensive overview of both the basic and clinical concepts relating to each topic, when appropriate. Chapter authors were chosen based on their high level of expertise and leadership in the field. Taken together, this text should thus be of great interest to physicians of multiple specialties, allied health professionals, as well as basic and clinical researchers.
Identification Of Genetic Susceptibility Factors To Osteoporosis In The Irish Population
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Author : Freda Maria Wynne
language : en
Publisher:
Release Date : 2002
Identification Of Genetic Susceptibility Factors To Osteoporosis In The Irish Population written by Freda Maria Wynne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Osteoporosis categories.
Osteoporosis is a disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue, leading to increased susceptibility to fractures. There is strong evidence to suggest that the procurement and preservation of peak bone mineral density is genetically determined. Peak bone density is achieved by the third decade of life after which bone is maintained by a careful balance between bone resorption and bone formation. Bone loss occurs with ageing when bone resorption occurs at a greater rate than bone formation. Heritability accounts for up to 90% of the variability in BMD. A two stranded approach was taken to identify genetic factors responsible for susceptibility to low BMD: population-based association studies using candidate genes and a sib-pair linkage study investigating candidate loci in the genome for linkage to a low BMD phenotype. Population-based association studies involved polymorphisms in the osteoprotegerin (OPG) gene, type 1 collagen alpha 1 (COLIAI) Sp1 binding site and vitamin D receptor (VDR) start codon. Following a systematic screening of the regulatory and coding regions of the OPG gene, we identified a novel G1181C polymorphism in exon 1 and a T950C polymorphism in the promoter region of the OPG gene were identified. 381 postmenopausal women aged 61.26+/-8.50 (mean+/-SD) and 130 premenopausal women aged 46.30+/6.50 (mean+/-SD) were analysed. It was found that postmenopausal women carrying one or more C alleles of the G1181C polymorphism had 14.8% lower BMD (p=0.05) at the lumbar spine (LS) and 14.4% lower BMD (p=0.04) at the femoral neck (FN). However, both were non-significant when the Bonferroni correction factor (0.01 significance level) was applied to correct for multiple hypothesis testing. No association was found between alleles of the OPG T950C, the VDR FokI or COL1A1 Sp1 polymorphism and BMD in either postmenopausal or premenopausal women in this population. The second stage in mapping susceptibility genes to low BMD involved a sib-pair linkage study to investigate the role of seventeen microsatellite markers at five chromosomal loci, in 175 families of probands with primary low BMD (T-score
Clinical Gynecology
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Author : Eric J. Bieber
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-23
Clinical Gynecology written by Eric J. Bieber and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-23 with Medical categories.
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.