Genetic Manipulation Of The Nervous System
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Genetic Manipulation Of The Nervous System
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-11-24
Genetic Manipulation Of The Nervous System written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-24 with Science categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.
Viral Vectors
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Author : Michael G. Kaplitt
language : en
Publisher:
Release Date : 1995
Viral Vectors written by Michael G. Kaplitt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Central nervous system categories.
Gene Transfer And Therapy In The Nervous System
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Author : Fred H. Gage
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gene Transfer And Therapy In The Nervous System written by Fred H. Gage and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Gene transfer technology is a powerful tool for increasing our understandingof brain functions. It is also the basis of gene therapy, which is now technically possible for the correction of many human diseases, including several disorders of the nervous (and muscular) system such as Alzheimer's disease, Parkinson's disease, and dystrophy. This volume,which contains the proceedings of a symposium of the Fondation Ipsen, provides a unique view of the state of the art on different transgenes, vectors, target cells, and clinical applications related to the nervous system.
Viral Vectors
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Author : Michael G. Kaplitt
language : en
Publisher: Academic Press
Release Date : 1995-08-14
Viral Vectors written by Michael G. Kaplitt and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-08-14 with Science categories.
Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells. Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers. This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.
Genome Editing In Neurosciences
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Author : Rudolf Jaenisch
language : en
Publisher: Springer
Release Date : 2017-09-14
Genome Editing In Neurosciences written by Rudolf Jaenisch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Advancing Gene Targeted Therapies For Central Nervous System Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-12-01
Advancing Gene Targeted Therapies For Central Nervous System Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-01 with Medical categories.
On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.
Protocols For Gene Transfer In Neuroscience
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Author : P. R. Lowenstein
language : en
Publisher:
Release Date : 1996-07-25
Protocols For Gene Transfer In Neuroscience written by P. R. Lowenstein and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-25 with Medical categories.
Protocols for Gene Transfer in Neuroscience Towards Gene Therapy of Neurological Disorders Edited by P. R. Lowenstein University of Manchester, UK and L. W. Enquist Princeton University, USA The brain and the cells that compose it have always presented unique barriers to any kind of outside interventions, including drug delivery, surgical procedures and the genetic manipulation of cells. However, these barriers are now being bypassed by the new technology of gene delivery. Protocols for Gene Transfer in Neuroscience is the first practical guide to gene delivery, providing over 150 easy to follow, step-by-step protocols, together with troubleshooting hints and the theoretical background needed for neuroscientists to understand, adapt and expand the technology as needed. Written by a team of international expert neuroscientists, geneticists, molecular biologists and biochemists, Protocols for Gene Transfer in Neuroscience describes the latest techniques from the top gene-delivery labs, ranging from physical transfection techniques, through the use of a wide range of viral vectors, to retrovirally transduced cell and bone marrow transplantation. Several variations of a single protocol are given, thus demonstrating how different labs have solved a common problem in different ways. The protocols are also indexed and cross-referenced so that an investigator can find all the details required for a particular problem.
Molecular Genetics In Developmental Neurobiology
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Author : Yasuzō Tsukada
language : en
Publisher: VSP
Release Date : 1986-01-01
Molecular Genetics In Developmental Neurobiology written by Yasuzō Tsukada and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-01-01 with Science categories.
Molecular genetics in neurobiology has developed rapidly with the introduction of the new and productive methodologies of genetic engineering and cell manipulation. Particularly in the field of developmental neurobiology, molecular genetics has had impact in research on the molecular mechanism of development and differentiation in the nervous system. This volume comprises 20 articles grouped into the following areas: cell recognition, embryo and gene manipulation, gene analysis and manipulation, and neural recognition. The authors have reviewed and interpreted their most recent results reflecting new concepts and ideas in the molecular approach to neurobiology.
Methods In Genomic Neuroscience
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Author : Hemin R. Chin
language : en
Publisher: CRC Press
Release Date : 2001-09-26
Methods In Genomic Neuroscience written by Hemin R. Chin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-26 with Science categories.
The past few years have witnessed extraordinary advances in molecular genetic techniques and the accumulation of structural genomics information and resources in both human and model organisms. With the development of new technologies and the availability of resources like the sequence of eukaryotic genomes, problems of a previously unthinkable sco
Neural Transplantation
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Author : William J. Freed
language : en
Publisher: MIT Press
Release Date : 2000
Neural Transplantation written by William J. Freed and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Central nervous system categories.
After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.