Genetic Manipulation Of The Nervous System
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Genetic Manipulation Of The Nervous System
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-11-24
Genetic Manipulation Of The Nervous System written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-24 with Science categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.
Gene Therapy Of The Central Nervous System From Bench To Bedside
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Author : Michael G. Kaplitt
language : en
Publisher: Gulf Professional Publishing
Release Date : 2006
Gene Therapy Of The Central Nervous System From Bench To Bedside written by Michael G. Kaplitt and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Few areas of biomedical research provide greater opportunities to capitalize upon the revolution in genomics and molecular biology than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy in the Brain: From Bench to Bedside represents the definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped to create the field as well as those who are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects which would be of interest to anyone who is currently using or contemplating exploring gene therapy for neurobiological applications. Basic gene transfer technologies are discussed, with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells. Numerous research applications are reviewed, particularly in complex fields such as behavioral neurobiology. Several preclinical areas are also covered which are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis. Among the most exciting advances in recent years has been the use of neurological gene therapy in human clinical trials, including Parkinson's disease, Canavan disease and Batten disease. Finally, readers will find "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use. This work provides up-to-date information and key insights into those gene therapy issues which are important to both scientists and clinicians focusing upon the brain and central nervous system.
Principles Of Gene Manipulation And Genomics
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Author : Sandy B. Primrose
language : en
Publisher: John Wiley & Sons
Release Date : 2013-05-28
Principles Of Gene Manipulation And Genomics written by Sandy B. Primrose and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-28 with Science categories.
The increasing integration between gene manipulation and genomics is embraced in this new book, Principles of Gene Manipulation and Genomics, which brings together for the first time the subjects covered by the best-selling books Principles of Gene Manipulation and Principles of Genome Analysis & Genomics. Comprehensively revised, updated and rewritten to encompass within one volume, basic and advanced gene manipulation techniques, genome analysis, genomics, transcriptomics, proteomics and metabolomics Includes two new chapters on the applications of genomics An accompanying website - www.blackwellpublishing.com/primrose - provides instructional materials for both student and lecturer use, including multiple choice questions, related websites, and all the artwork in a downloadable format. An essential reference for upper level undergraduate and graduate students of genetics, genomics, molecular biology and recombinant DNA technology.
Gene Therapy For Neurological Disorders And Brain Tumors
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Author : E. Antonio Chiocca
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-10-23
Gene Therapy For Neurological Disorders And Brain Tumors written by E. Antonio Chiocca and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10-23 with Science categories.
Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.
Central Nervous System Diseases
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Author : Dwaine F. Emerich
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-11-24
Central Nervous System Diseases written by Dwaine F. Emerich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-24 with Science categories.
Prominent experimentalists critically review the animal models widely used in developing powerful new therapies for central nervous system diseases. Coverage includes novel uses of animal models of Alzheimer's, Parkinson's, and Huntington's diseases, and studies of aging. Techniques that rely heavily on behavioral analyses, as well as models developed from infusions of neurotoxins and from advances in molecular biology, are thoroughly explicated, as are models developed for more acute neurological conditions, including traumatic brain injury and stroke. Comprehensive and authoritative, Central Nervous System Diseases: Innovative Animal Models from Lab to Clinic offers neuroscientists, pharmacologists, and interested clinicians a unique survey of the most productive animal models of the leading neurological diseases currently employed to develop today's innovative drug therapies.
The Nervous System
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Author : Mayeen Uddin Khandaker
language : en
Publisher: Elsevier
Release Date : 2025-03-04
The Nervous System written by Mayeen Uddin Khandaker and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-04 with Science categories.
The series Stem Cell Innovation in Health and Disease is a timely and fascinating collection of information and new discoveries and provides a contemporary snapshot album from the fast-moving field of regenerative medicine and stem cell therapeutics. The Nervous System, Volume 5 addresses the recent data accumulated on the potential applications of stem cells to treat diseases and disorders of the nervous system. This volume will highlight the recent development of cutting edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to treat nervous system disorders and diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. - Providess cutting-edge research to understand stem cell functions used in disease and disorder treatments of the nervous system - Develops processes to bring stem cells from bench to bedside - Includes up to date references on stem cell biology and function in common nervous system diseases and disorders
Unraveling Genetic Mysteries Longevity Genetic Engineering And Philosophy Of Mind
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date :
Unraveling Genetic Mysteries Longevity Genetic Engineering And Philosophy Of Mind written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on with Health & Fitness categories.
Genetics is a fascinating and complex field, which reveals the secrets of the genetic code present in every living being. Through the investigation of genes and their interaction with the environment, we are able to better understand the biological processes that shape our existence. In this book, we'll explore the wonders and challenges of genetics, as well as its applications in areas such as medicine, criminal investigation, and genetic engineering. The first part of this book will take us through the intricate world of the genetics of aging and longevity. We will investigate the genetic mechanisms that determine the rate of aging of organisms and explore the possibilities of prolonging a healthy life. We'll discover how the latest research is unlocking the mysteries of aging and offering new insights into human longevity. Then we will enter the field of genetic engineering and genetically modified organisms (GMOs). We will explore the innovative techniques that allow the manipulation of DNA and the creation of organisms with specific characteristics. We'll see how this technology is revolutionizing agriculture, medicine, and industry, while raising important ethical and environmental questions. Forensic genetics will also gain prominence on our journey. We will investigate how DNA analysis has become a powerful tool in solving crimes, unraveling mysteries and assisting in the pursuit of justice. We'll discover how technological advances are revolutionizing criminal investigation and providing a deeper understanding of the genetic bonds between individuals. Entering the field of health, we will explore the genetics of neurodegenerative, cardiovascular, autoimmune and psychiatric disorders. We will understand how genes play a key role in the development of these diseases and how this understanding can open the way to more effective treatments and prevention strategies. In addition, we will investigate pharmacogenomics and precision medicine, examining how genetic individuality influences individuals' response to medications, enabling personalized and more effective treatments. We'll also cover the genetics of metabolism and obesity, sleep disorders, and the genetic implications for these conditions. The second part of this book will take us on a philosophical journey into the world of the mind. We'll explore debates about the nature of consciousness, the mind-body problem, reductionism, and dualism. We will investigate the relationship between the mind and the brain, the question of personal identity over time, and the philosophical implications of the mind in relation to artificial intelligence, free will, neuroscience, qualia, and even animal consciousness.
Nincds Index To Research Grants Subject Number Investigator Contracts
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Author : National Institute of Neurological and Communicative Disorders and Stroke
language : en
Publisher:
Release Date : 1980
Nincds Index To Research Grants Subject Number Investigator Contracts written by National Institute of Neurological and Communicative Disorders and Stroke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Cerebrovascular disease categories.
Nincds Index To Research Grants And Contracts
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Author : National Institute of Neurological and Communicative Disorders and Stroke
language : en
Publisher:
Release Date : 1981
Nincds Index To Research Grants And Contracts written by National Institute of Neurological and Communicative Disorders and Stroke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Cerebrovascular disease categories.
Genetic Engineering Of Viruses And Viral Vectors
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Author : Proceedings of the National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 1996-01-01
Genetic Engineering Of Viruses And Viral Vectors written by Proceedings of the National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Nature categories.