Genetic Variants And Metabolic Diseases Volume Ii
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Genetic Variants And Metabolic Diseases Volume Ii
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Author : Tarunveer Singh Ahluwalia
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-12
Genetic Variants And Metabolic Diseases Volume Ii written by Tarunveer Singh Ahluwalia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-12 with Medical categories.
Metabolic syndrome (MetS) is a set of co-morbidities that collectively increase an individual’s risk of developing cardiovascular disease, stroke, and type 2 diabetes mellitus (T2D). Per the World Health Organization (WHO), MetS is typically characterized by obesity, insulin resistance, hypertension, and hyperlipidemia. Building on this point, some of the major risk factors for development of MetS include increased weight or an obese phenotype, lack of physical activity, and genetics. Interestingly, the last decade has witnessed a deluge of Genome-Wide Association Studies (GWAS) that have linked hundreds of genomic with both collective MetS traits, as well as individual metabolic disorders sitting within it. Currently, in the post-GWAS era, the focus has shifted to characterization of these novel genomic to establish causality and disease relevance. This is being pursued by way of functional validation such as gain- and loss-of-function studies, investigating resulting metabolic phenotypes, mechanisms and pathways underlying these phenotypes, their prevalence and potential for risk stratification across populations, and finally, identification of therapeutic targets for pharmacological intervention.
Metabolic Diseases
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Author : E. Gilbert-Barness
language : en
Publisher: IOS Press
Release Date : 2017-01-06
Metabolic Diseases written by E. Gilbert-Barness and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-06 with Medical categories.
The 2nd Edition of Metabolic Diseases provides readers with a completely updated description of the Foundations of Clinical Management, Genetics, and Pathology. A distinguished group of 31 expert authors has contributed 25 chapters as a tribute to Enid Gilbert-Barness and the late Lewis Barness--- both pioneers in this topic. Enid’s unique perspectives on the pathology of genetic disorders and Lew’s unsurpassed knowledge of metabolism integrated with nutrition have inspired the contributors to write interdisciplinary descriptions of generally rare, and always challenging, hereditary metabolic disorders. Discussions of these interesting genetic disorders are organized in the perspective of molecular abnormalities leading to morphologic disturbances with distinct pathology and clinical manifestations. The book emphasizes recent advances such as development of improved diagnostic methods and discovery of new, more effective therapies for many of the diseases. It includes optimal strategies for diagnosis and information on access to specialized laboratories for specific testing. The target audience is a wide variety of clinicians, including pediatricians, neonatologists, obstetricians, maternal-fetal specialists, internists, pathologists, geneticists, and laboratorians engaged in prenatal and/or neonatal screening. In addition, all scientists and health science professionals interested in metabolic diseases will find the comprehensive, integrated chapters informative on the latest discoveries. It is our hope that the 2nd Edition will open new avenues and vistas for our readers and that they will share with us the interest, excitement and passion of the research into all these challenging disorders.
Novel Therapeutic Target And Drug Discovery For Neurological Diseases Volume Ii
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Author : Rui Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2025-03-12
Novel Therapeutic Target And Drug Discovery For Neurological Diseases Volume Ii written by Rui Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-12 with Science categories.
This Research Topic is the second volume of the Research Topic " Novel Therapeutic Target and Drug Discovery for Neurological Diseases". Please see the first volume here. Neurological diseases represent heterogeneous disorders that involve complex pathological alterations with only a few effective treatments; therefore, there is a great need for the development of novel therapeutic targets and therapies. There are more than six hundred neurological disorders, including dementia, cerebrovascular diseases, mental illness, brain tumor, and infection-caused central diseases, all arising from disruption to the central nervous system. Researchers are attempting to identify promising targets and potential drug candidates from new biological techniques and pharmacological animal studies. Thus, novel target discovery and mechanism elucidation, as well as the development of small-molecule entities, natural compounds, and polypeptides for the treatment of neurological dysfunction, may offer exciting clues for novel therapeutic strategies to halt or mitigate the course of neurological diseases.
Systems Genetics Of Human Complex Diseases Volume Ii
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Author : Guiyou Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-19
Systems Genetics Of Human Complex Diseases Volume Ii written by Guiyou Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-19 with Science categories.
Genetic Variants And Metabolic Diseases
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Author : Kavita Jadhav
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-29
Genetic Variants And Metabolic Diseases written by Kavita Jadhav and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-29 with Medical categories.
Covid 19 And Diabetes Volume Ii
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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-17
Covid 19 And Diabetes Volume Ii written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-17 with Medical categories.
Osteo Sarcopenia Sarcopenic Obesity Volume Ii
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Author : Yannis Dionyssiotis
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-30
Osteo Sarcopenia Sarcopenic Obesity Volume Ii written by Yannis Dionyssiotis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-30 with Medical categories.
Sarcopenia is a geriatric syndrome with progressive loss of mass, quality and function of skeletal muscles associated with aging. Its prevalence may reach 30% for people over 60 in European populations. Sarcopenia is a multifactorial process: some factors lead to the development of sarcopenia and its associated negative effect on physical function. The loss of skeletal muscle fibers secondary to the reduced number of motor neurons appears to contribute significantly to the disorder, which may further include reduced levels of hormones (particularly GH, IGF-1, MGF, and testosterone), lack of protein and calories of the diet, oxidative stress, inflammatory processes etc. Sarcopenia requires a rehabilitation program to improve physical performance but also nutritional interventions: protein supplementation combined with exercise, leucine-enriched amino acids and vitamin D supplementation, as adjunctive therapy.
Genetics And Epigenetics Of Psychiatric Diseases Volume Ii
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Author : Cunyou Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-16
Genetics And Epigenetics Of Psychiatric Diseases Volume Ii written by Cunyou Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-16 with Science categories.
Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii
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Author : Che-Pei Kung
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-30
Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii written by Che-Pei Kung and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-30 with Medical categories.
The relationship between metabolic dysfunctions and cancer development has been continuously evolving, informed by research efforts in the fields of epidemiology, endocrinology, cancer biology, chemistry, genomics, metabolomics among others. Metabolism and cancer can intersect at the physiological level, where metabolic disorders and cancer malignancies occur as comorbid or mutually-promoting conditions; or at the molecular level, where metabolic alterations regulate tumorigenesis and oncogenic/tumor-suppressive pathways govern the onset of metabolic syndromes. The increasingly complex spider web connecting metabolic dysfunctions and cancer development reveals both distinctive and shared mechanisms underlying different disease indications. It also points to unique opportunities, either through repurposing existing tools or discovering new strategies, to develop targeted therapies against a wide variety of metabolic and cancerous diseases. In our previous Research Topic: Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both Metabolic Disease and Cancer , we highlighted ten genetic factors/mechanisms that influence the pathogenesis of both metabolic disease and cancer. The attention it generated to date ( >110,000 article views, >22,000 article downloads, >500 citations) signals a fast-growing interest from scientific communities of different disciplines. We aim to highlight more recent advances to inform a diverse audience working on basic and translational research.
Advancing Genomics For Rare Disease Diagnosis And Therapy Development Vol Ii
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Author : Weida Tong
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-07
Advancing Genomics For Rare Disease Diagnosis And Therapy Development Vol Ii written by Weida Tong and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Science categories.