Genetically Engineered Mice Handbook
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Genetically Engineered Mice Handbook
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Author : John P. Sundberg
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Genetically Engineered Mice Handbook written by John P. Sundberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
This comprehensive book covers all aspects of the field of genetically engineered laboratory mice, including the creation of mutant mice through mouse models for developmental biology and the monitoring of laboratory mouse colonies. Written by leading biomedical investigators, pathologists, and clinicians, this book presents systematic approaches for analyzing mutant laboratory mice for specific medical applications. It provides a variety of methods for creating mutant mice, while covering legal aspects of mutant and inbred laboratory mice as well as the use and maintenance of international databases.
Transgenic Animal Technology
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Author : Carl A. Pinkert
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Transgenic Animal Technology written by Carl A. Pinkert and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat. One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology. Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols New section on analysis
Transgenic Animal Technology
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Author : Carl A. Pinkert
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Transgenic Animal Technology written by Carl A. Pinkert and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Technology & Engineering categories.
Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions, as well as to make practical applications to production agriculture. This well-illustrated handbook covers the technical aspects of gene transfer in animals--from molecular methods to whole animal considerations--for the important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Describes mouse model systems Covers laboratory and domestic animal species Illustrated with diagrams and photographs Includes useful tables and charts
Handbook Of Mouse Mutations With Skin And Hair Abnormalities
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Author : John P. Sundberg
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Handbook Of Mouse Mutations With Skin And Hair Abnormalities written by John P. Sundberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
Mouse Phenotypes
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Author : Virginia E. Papaioannou
language : en
Publisher: CSHL Press
Release Date : 2005
Mouse Phenotypes written by Virginia E. Papaioannou and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.
Transgenic Mouse Methods And Protocols
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Author : Marten H. Hofker
language : en
Publisher: Humana Press
Release Date : 2011-08-24
Transgenic Mouse Methods And Protocols written by Marten H. Hofker and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-24 with Science categories.
The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in the context of a whole organism, making them particularly useful. In Transgenic Mouse Methods and Protocols, Second Edition, expert research explore current advances in the field through detailed laboratory protocols. Chapters provide a general introduction outlining how to deal with mice and how to generate transgenic mouse models, explore the generation of conditional and induced knockout and transgenic mice, and offer alternative routes to studying gene function in mice. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and state of the art, Transgenic Mouse Methods and Protocols, second Edition is the ideal guide for all researchers interested in the latest information about the production and analysis of transgenic and knockout mice.
Handbook Of Laboratory Animal Science Second Edition
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Author : Jann Hau
language : en
Publisher: CRC Press
Release Date : 2003
Handbook Of Laboratory Animal Science Second Edition written by Jann Hau and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
This second edition of a text for students specializing in laboratory animal science expands coverage to include material on genetic engineering, phenotype characterization of genetically engineered mice, surgical techniques, monitoring the well-being of animals, and the treatment of pain and suffering in laboratory animals. There is discussion of general methods including experimental design and statistical evaluations, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Safety and security in facilities is examined, and Australasian legislation and regulation are covered. The book is also useful as a reference for biomedical researchers, managers, quality assurance professionals, and technicians. Hau teaches comparative medicine at the University of Uppsala, Sweden; Van Hoosier, at the University of Washington. Annotation copyrighted by Book News, Inc., Portland, OR.
Handbook Of Laboratory Animal Science Animal Models
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Author : Jann Hau
language : en
Publisher:
Release Date : 2003
Handbook Of Laboratory Animal Science Animal Models written by Jann Hau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Animal experimentation categories.
This second edition of a text for students specializing in laboratory animal science expands coverage to include material on genetic engineering, phenotype characterization of genetically engineered mice, surgical techniques, monitoring the well-being of animals, and the treatment of pain and suffering in laboratory animals. There is discussion of general methods including experimental design and statistical evaluations, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Safety and security in facilities is examined, and Australasian legislation and regulation are covered. The book is also useful as a reference for biomedical researchers, managers, quality assurance professionals, and technicians. Hau teaches comparative medicine at the University of Uppsala, Sweden; Van Hoosier, at the University of Washington. Annotation copyrighted by Book News, Inc., Portland, OR.
Handbook Of Laboratory Animal Science Animal Models
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Author : Jann Hau
language : en
Publisher:
Release Date : 2003
Handbook Of Laboratory Animal Science Animal Models written by Jann Hau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Animal experimentation categories.
Guide To Techniques In Mouse Development Part B
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Author : Paul Wassarman
language : en
Publisher: Academic Press
Release Date : 2010-09-24
Guide To Techniques In Mouse Development Part B written by Paul Wassarman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-24 with Science categories.
This volume comprehensively covers new technologies and methodologies that have appeared for the study of mouse development. This volume is Part B of an update of volume 225, Guide to Techniques in Mouse Development, edited by P.M. Wassarman and M.L. DePamphilis and published in 1993. Comprehensively covers new techniques for the cryopreservation of gametes and embryos, production of transgenic and null (knockout) animals (use of ES cells), generation of conditional/inducible mutant animals, use of gene-trap mutagenesis, analysis of allele-specific expression, use of new reporter constructs, humanizing of transgenic animals, transcript profiling of mouse development, imaging of mouse development, and rederivation of animals and use of mouse genomics.