Genetics And Genomics Of Candida Albicans Biofilm Formation Identification Of A New Adherence Regulatory Pathway
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Genetics And Genomics Of Candida Albicans Biofilm Formation Identification Of A New Adherence Regulatory Pathway
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Author : Clarissa Jane Nobile
language : en
Publisher:
Release Date : 2007
Genetics And Genomics Of Candida Albicans Biofilm Formation Identification Of A New Adherence Regulatory Pathway written by Clarissa Jane Nobile and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Candida albicans biofilm formation is a poorly understood, complex biological process with significant consequences for human health. In this thesis, I describe the progress I have made in elucidating the genetic mechanisms of Candida albicans biofilm formation using a large-scale gene disruption strategy. The Bcr1-dependent adherence regulatory pathway that I discovered is pivotal to our understanding of C. albicans biofilm formation. Without the transcription factor Bcr1, named for Biofilm and Cell-wall Regulator, C. albicans cells are unable to form biofilms, a process that is extremely important to its lifestyle and pathogenicity. Expression analysis indicates that Bcr1 activates cell surface protein and adhesin genes, whose gene products could be used to develop new anti-fungal therapies.
Candida And Candidiasis
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Author : Richard A. Calderone
language : en
Publisher: American Society for Microbiology Press
Release Date : 2011-12-07
Candida And Candidiasis written by Richard A. Calderone and has been published by American Society for Microbiology Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-07 with Medical categories.
The underlying mechanisms of Candida and candidiasis and promising new directions in drug discovery and treatment. • Reviews all aspects of this common fungal pathogen and its impact on human health, from the basic biology of Candida albicans to the clinical management of candidiasis. • Reviews the latest basic and clinical research, focusing on findings in genome variability, host-pathogen interactions, antifungal resistance and drug discovery, and diagnostics to foster better understanding and treatment of candidiasis. • Examines recent discoveries that have shed light on morphogenesis and the cell cycle, including how new findings on host responses may have applications for the diagnosis of blood-borne candidiasis.
Human Fungal Pathogens
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Author : Oliver Kurzai
language : en
Publisher: Springer
Release Date : 2013-12-16
Human Fungal Pathogens written by Oliver Kurzai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-16 with Medical categories.
Whereas plant and insect infections are commonly caused by fungi, only a small minority of the vast diversity of fungal species is pathogenic to humans. Despite this, fungal infections cause considerable morbidity and mortality worldwide. This volume is dedicated to the biology, clinical presentation and management of invasive fungal infections. Major pathogenic fungi are introduced by world-leading experts and the basic principles of fungal virulence are reviewed in the light of new results and experimental technologies that offer unprecedented insights into invasive infections caused by Aspergillus, Candida, Cryptococcus, Pneumocystis and Mucorales. In parallel, the clinical presentation of invasive fungal infections and current approaches to their diagnosis and treatment are summarized to provide an overview of human pathogenic fungi, linking pathogen biology to the clinical presentation of disease.
Candida
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Author : Christophe d'. Enfert
language : en
Publisher: Caister Academic Press Limited
Release Date : 2007
Candida written by Christophe d'. Enfert and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
Candida species are important human pathogens that are best known for causing opportunist infections in immunocompromised hosts (e.g. transplant patients, AIDS sufferers, cancer patients). Infections are difficult to treat and can be very serious. 30-40% of systemic infections result in death. The sequencing of the genome of C. albicans and those of several other medically-relevant Candida species has provided a major impetus for Candida comparative and functional genomic analyses. These have provided a fascinating insight into the molecular and cellular biology of these fungi, and these should pave the way for the development of more sensitive diagnostic strategies and novel antifungal therapies. In this timely book, international experts provide comprehensive and authoritative reviews of these important organisms. The topics covered include: genome dynamics of C. albicans; molecular, epidemiological, and population studies of C. albicans; the parasexual cycle in C. albicans; comparative genomics of the hemiascomycetes group and of different Candida species; databases and the challenges that their curators are facing; transcriptome analysis; proteomics; molecular evolution of the genetic code; stress responses; regulation of morphogenesis; cell wall biology; interaction with host cells; analysis of gene function; antifungal resistance mechanisms; and much more. This book is essential reading for all Candida genome and molecular biology researchers and a recommended text for scientists working on fungal genomics and molecular biology.
Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2007
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Dissertations, Academic categories.
Medical Biofilms
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Author : Jana Jass
language : en
Publisher: John Wiley & Sons
Release Date : 2003-04-02
Medical Biofilms written by Jana Jass and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-04-02 with Science categories.
Biofilms are formed by microorganisms growing on surfaces and comprise a series of microcolonies interspersed with spaces through which fluids and other microorganisms move. In medicine, the primary problems are biofilms associated with implants: infections are increasingly difficult to treat with traditional antibiotics and removal of the implant often becomes essential, frequently leading to higher morbidity and mortality. This will be the first book dedicated to medical biofilms. It will cover much recent information on the problems of biofilms, how to detect them and how to control their presence.
Genomic Characterization Of Emerging Human Fungal Pathogens
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Author : Christina A. Cuomo
language : en
Publisher: Frontiers Media SA
Release Date : 2021-05-25
Genomic Characterization Of Emerging Human Fungal Pathogens written by Christina A. Cuomo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-25 with Science categories.
The Yeast Role In Medical Applications
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Author : Waleed Mohamed Hussain Abdulkhair
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-01-17
The Yeast Role In Medical Applications written by Waleed Mohamed Hussain Abdulkhair and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-17 with Technology & Engineering categories.
Biotechnology including medical applications depends on the yeast as biofermenter to produce many industrial products including pharmaceutical ones. Although yeasts are first known as useful microorganisms, some of them are identified as pathogens for plants, animals, and humans. Due to the simple cellular structure of the yeast among other microbial groups, it is used in the earliest investigations to determine the features of eukaryotic molecular biology, cell biology, and physiology. The economic income of some countries mainly depends on yeast for producing the economic products, such as France that depends on yeast for wine production. This book throws light on yeast and its important role in the medical applications.
The Fungal Cell Wall
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Author : Jean-Paul Latgé
language : en
Publisher: Springer Nature
Release Date : 2020-08-12
The Fungal Cell Wall written by Jean-Paul Latgé and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-12 with Science categories.
This book illustrates, that the fungal cell wall is critical for the biology and ecology of all fungi and especially for human fungal pathogens. Readers will learn, that the composition of the fungal cell wall is a unique structure, which cannot be found in the human host. Consequently, the chapters outline, how the immune systems of both animals and humans have evolved to recognize conserved and unique elements of the fungal cell wall. As an application example, the authors also show, that the three-dimensional structures of the cell wall are excellent targets for the development of antifungal agents and chemotherapeutic strategies. With the combination of biological findings and medical outlooks, this volume is a fascinating read for scientists, clinicians and biomedical students.
Bacterial Biofilms
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Author : Sadik Dincer
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-10-07
Bacterial Biofilms written by Sadik Dincer and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-07 with Science categories.
This book examines biofilms in nature. Organized into four parts, this book addresses biofilms in wastewater treatment, inhibition of biofilm formation, biofilms and infection, and ecology of biofilms. It is designed for clinicians, researchers, and industry professionals in the fields of microbiology, biotechnology, ecology, and medicine as well as graduate and postgraduate students.