Genetics Of Angiogenesis
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Genetics Of Angiogenesis
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Author : James Hoying
language : en
Publisher: Garland Science
Release Date : 2003-12-16
Genetics Of Angiogenesis written by James Hoying and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-16 with Science categories.
Angiogenesis research is one of the most quickly developing areas in biomedicine. It is considered to be a common denominator in society's most important diseases and pharmaceutical companies are racing to develop new angiogenesis-based drugs. This volume focuses on the genetic control of angiogenesis, both in humans and model organisms, and will be a valuable resource to all researchers in the field, including the fundamentals of the process as well as workers in biotechnology.
Angiogenesis In Vivo Systems
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Author : David A. Cheresh
language : en
Publisher: Academic Press
Release Date : 2009-02-12
Angiogenesis In Vivo Systems written by David A. Cheresh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-12 with Science categories.
Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing. * Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition. * Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques. * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics
Vascular Development
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-20
Vascular Development written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-20 with Science categories.
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Investigating Mechanisms Of Angiogenesis In Health And Disease Using Zebrafish Models
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Author : Zaheer Ali
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-12-07
Investigating Mechanisms Of Angiogenesis In Health And Disease Using Zebrafish Models written by Zaheer Ali and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with categories.
Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. Pathological vessels are poorly developed, insufficiently perfused and highly leaky, phenotypes that are considered to drive disease progression and lead to poor prognosis. Currently, a number of anti-angiogenic drugs exists, the majority of which target vascular endothelial factor (VEGF), but although they often are highly beneficial for treating eye diseases in the short-term, they are generally of limited efficacy in other diseases such as cancer, and also have poorer efficacy when used for treatment of eye diseases in the long-term. A better understanding of the mechanisms underlying pathological angiogenesis can generate new targets for treatment leading to development of better drugs for cancer and retinopathies, but perhaps also other angiogenesis-dependent diseases, in the future. In this thesis mechanisms involved in developmental angiogenesis or pathological angiogenesis in the choroid, cornea or melanoma was identified. These findings highlight the need to further elaborate our knowledge related to angiogenesis in different tissues/conditions for a more targeted, and potentially effective treatment of diseases in the future. In paper I, we for the first time identified the choriocapillaries (CCs) in adult zebrafish and found that occult CNV could be induced by exposing the fish to severe hypoxia. Interestingly, we found that occult CNV relied on intussusception, involving not only de novo generation of intussusceptive pillars but also a previously poorly understood mechanism called pillar splitting. This involved HIF-VEGF-VEGFR2 signaling and evidence that this also occurred in both rats and humans suffering from AMD suggested that the mechanism was conserved and clinically relevant. In contrast, we found in paper II that the development of CCs in the zebrafish relies on sprouting angiogenesis, involve continuous remodeling, and delayed maturation of the vasculature in 2D. The initial development was found to occur by a unique process of tissuewide synchronized vasculogenesis. As expected, VEGFA via VEGFR2 was also critical for the development of these vessels in the zebrafish embryo, but surprisingly this was independent on hypoxia-inducible factor (HIF)-1. Inflammatory nuclear factor-kB (NF-kB) signaling is involved in the progression of angiogenesis, but this signaling pathway has mainly been studied in the inflammatory cells and the role of NF-kB in the endothelial cells during angiogenesis is poorly understood. In paper III, we found that blocking NF-kB signaling using a specific IKK2 blocker IMD0354, specifically blocks pathological as well as developmental angiogenesis by targeting endothelial cell NF-kB signaling in the endothelial cells. Using a rat model for suture-induced corneal neovascularization, IMD0354 treatment lead to reduced production of inflammatory C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine ligand 5 (CXCL5) and VEGF, and thereby reduced pathological corneal angiogenesis in this model. Using the zebrafish tumor xenograft model in paper IV, we found an association between Microphthalmia associated transcription factor (MITF) and pigment epithelium derived factor (PEDF), which was involved in pathological tumor angiogenesis and metastasis. Similarly, in paper V we used zebrafish transplantation models to study and investigate the use of biocompatible polymers for the delivery of pro-angiogenic FGF-2 as a potential treatment strategy for ischemic diseases such as myocardial infarction (MI). Conclusively, this thesis provides new insights into diverse fields of angiogenic assays using zebrafish, and reveals new mechanisms of angiogenesis in health and disease. This work will hopefully provide a foundation for further studies into occult CNV related to AMD, a process that has not been possible to study previously in pre-clinical models. In addition, zebrafish xenograft or other transplantation models used in this work will likely be important to study cancer biology and to develop more attractive pharmaceutical preparations based on biocompatible hydrogels formulated as microspheres in the future.
Identification Of Genes Regulating Angiogenesis And Targeted Reduction Of Antisense Therapy
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Author :
language : en
Publisher:
Release Date : 2001
Identification Of Genes Regulating Angiogenesis And Targeted Reduction Of Antisense Therapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Angiogenesis, the formation of new blood vessels from existing vessels, is a process critical to many normal physiologic processes However, uncontrolled capillary growth can have dramatic consequences, as seen in the rapid growth of well-vascularized tumors such as breast carcinoma. Indeed, failure to induce a new blood supply limits the size of a tumor dramatically. It is clear that controlling angiogenesis could have a major impact on treatment of breast cancer, the most common cancer in American women. Using a PCR-based screen (Representational Difference Analysis) we have identified several genes that are involved in formation of new blood vessels and that are upregulated in cultured capillary endothelial cells (EC) forming tubes (neo-capillaries) in collagen gels, but not in EC growing in monolayers. ESM-l is a secreted molecule that may be related to chondroitin sulfates. It is highly expressed in several tumors and appears to be regulated by the vascular endothelial growth factor, VEGF. Beta-ig-H3 is an extracellular matrix molecule involved in cross-linking of collagen fibers. Reducing its expression using antisense molecules blocks in vitro capillary formation. NrCAM is a "neural" adhesion molecule and is highly upregulated on tube-forming EC. We speculate that it may have a role in guidance of new vessels. HESR1 is a bHLH transcription factor that appears to control the switch from quiescence to migration and proliferation. It is downstream of the notch receptor and can suppress transcription of the VEGF receptor gene VEGFR2. Blocking HESRl induction with antisense blocks tube formation. By identifying genes differentially expressed during angiogenesis, and designing effective molecular therapies that reduce their expression and thereby reduce capillary growth, we hope to identify future targets for specific therapy aimed at blocking growth of solid tumors.
Tissue Specific Vascular Endothelial Signals And Vector Targeting
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-27
Tissue Specific Vascular Endothelial Signals And Vector Targeting written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-27 with Science categories.
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area Presents up-to-date research from leaders in the field
Angiogenesis
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Author : Michael E. Maragoudakis
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Angiogenesis written by Michael E. Maragoudakis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Medical categories.
Interest in angiogenesis research remains strong in recent years and exciting new discoveries, about modulators of angiogenesis, their receptors, the transduction mechanisms and the angiogenic genes involved, have contributed to our present day understanding of this complex process. This knowledge has provided the basis and broadened the scope of angiogenesis - based therapy in oncology and many other clinical conditions. This monograph contains the contributions to the NATO Advanced Study Institute on "Angiogenesis: Models, Modulators and Clinical Applications", which was held in Rhodes, Greece, from June 20-30, 1997. This was the fourth of a series of NATO supported international meetings on Angiogenesis aiming to bring together basic scientists with clinicians to exchange ideas, disseminate new knowledge and discuss the present status and potential new directions in this fast moving area of biomedical research. The International Organising Committee that included Drs. E. Dejana, C Haudenschild, M. Hackel, H. Kleinman, P. Lelkes, M. Presta, P. Polverini, D. Thompson, has provided invaluable help with their insightful suggestions in the formulation of the scientific program for which I am grateful. I wish to thank all the participants for their enthusiastic participation and their complimentary comments on the success of the conference.
Angiogenesis In Health Disease And Malignancy
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Author : Ali Salajegheh
language : en
Publisher: Springer
Release Date : 2016-03-10
Angiogenesis In Health Disease And Malignancy written by Ali Salajegheh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-10 with Medical categories.
This book is about “Angiogenesis”. A process in which new vasculature is formed from pre-existing capillaries. Angiogenesis process is associated with the proliferation and growth of both physiologically normal and neoplastic tissues, through the formation of vascular supply, essential for delivering growth requirements such as oxygen and nutrients. The book describes more than 100 genes and their key regulatory functions in the context of normal healthy condition, disease and malignancy, cancer proliferation and progression. New insights into the role of angiogenesis and the therapeutic inhibition of its regulators are investigated, due to the great potential for exploitation in the development of a novel treatment for cancer. New scientists, junior researchers and biomedical science students will find this book an invaluable introductory reference to their insight about angiogenesis and angiogenic role of more than 100 angiogenes and their role in healthy, disease and malignant conditions.
Angiogenesis And Vascularisation
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Author : Józef Dulak
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-10
Angiogenesis And Vascularisation written by Józef Dulak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-10 with Medical categories.
The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.
Gene Therapy Applications
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Author : Chunsheng Kang
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-08-23
Gene Therapy Applications written by Chunsheng Kang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-23 with Medical categories.
The aim of our book is to provide a detailed discussion of gene therapy application in human diseases. The book brings together major approaches: (1) Gene therapy in blood and vascular system, (2) Gene therapy in orthopedics, (3) Gene therapy in genitourinary system, (4) Gene therapy in other diseases. This source will make clinicians and researchers comfortable with the potential and problems of gene therapy application.