Genetics Of Psychopathology
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The Behavioral Genetics Of Psychopathology
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Author : Kerry L. Jang
language : en
Publisher: Routledge
Release Date : 2005-03-23
The Behavioral Genetics Of Psychopathology written by Kerry L. Jang and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-03-23 with Medical categories.
New discoveries about the genetic underpinnings of many kinds of human experience are now continually being made. This book explores the impact of these discoveries on the ways in which the common mental disorders are best conceptualized and treated. Most people think of research in genetics as the search for genes. This is only one focus of effort, and even with the reliable identification of susceptibility genes, the clinical applications of their discovery, such as gene therapies and new drug development, are a long way off. For the present, the impact of genetic research on our understanding of mental illness is tied to our ability to estimate the effect of all genes by means of family, twin, and adoption studies. The results of these studies challenge some deeply cherished ideas and theories, and support others. Of course, the effect of genes is only half the equation. The role of experience, environment, and living conditions accounts for as much, often considerably more, of the variability in psychopathology. In this book, Kerry Jang attempts not to answer questions about what is "genetic" and what is not, but about what a knowledge of the relative influence of genes versus environment means at a psychological level of analysis--to show how it changes common assumptions about classification, etiology, diagnosis, and intervention. He first offers an overview of contemporary behavioral genetics, dispels common misconceptions, responds to the criticisms that have been leveled at this new field, and describes in basic terms how genetic and environmental effects are estimated and how susceptibility genes are pinpointed. He then points to new directions in which standard nosological systems are likely to evolve as new information about vulnerabilities and covariances emerges. Finally, he synthesizes and evaluates the consistency of the last decade's findings for the most common categories of psychopathology that have been studied by behavior geneticists: mood, personality, and anxiety disorders, substance abuse; and schizophrenia and the psychotic disorders. Clinicians and researchers alike need to understand the genetic influences on the feelings and behaviors they are seeking to change or study if they are to be effective in their work. The Behavioral Genetics of Psychopathology: A Clinical Guide empowers them with this understanding.
Behavior Genetics Of Psychopathology
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Author : Soo Hyun Rhee
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-03
Behavior Genetics Of Psychopathology written by Soo Hyun Rhee and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-03 with Psychology categories.
As a dynamic, interdisciplinary field, behavior genetics and its evolution are being followed closely by scientists across the psychological and medical domains. The discoveries surrounding the human genome and the advancement in molecular genetic technologies have led to studies becoming increasingly sophisticated and yielding yet more conclusive and useful results. This is certainly the case in the area of child and adult psychopathology. Behavior Genetics of Psychopathology summarizes the state of the field, examining the role of genes and environment as they affect common neurodevelopmental and psychiatric conditions. Emphasizing key research areas (comorbidities, twin studies, the integration of methods), the book assesses the current literature, offers up-to-date findings, sorts through lingering controversies, and identifies a clear future agenda for the field. Expertly-written chapters focus on issues of both general salience that shape behavior genetics of psychopathology, to specific disorders of major clinical importance, among them: ADHD: the view from quantitative genetic research. Autism spectrum disorders and their complex heterogeneity Genetic influences on anxiety and depression in childhood and adolescence. Evidence for etiologically-defined subgroups within the construct of antisocial behavior. Sleep and psychopathology: the reasons for their co-occurrence. Behavioral genetic approaches to the etiology of comorbidity. Epigenetics of psychopathology. This combination of timeliness and depth of coverage make Behavior Genetics of Psychopathology a frontline resource for behavior geneticists, psychologists, psychiatrists, and neuroscientists, and is perfectly suited to graduate students looking to join these fields.
Genes Environment And Psychopathology
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Author : Kenneth S. Kendler
language : en
Publisher: Guilford Press
Release Date : 2007-11-01
Genes Environment And Psychopathology written by Kenneth S. Kendler and has been published by Guilford Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-01 with Psychology categories.
This groundbreaking volume synthesizes the results of the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders, which yielded longitudinal data on more than 9,000 individuals. The authors trace how risk for depression, anxiety, eating disorders, antisocial behavior, alcoholism, and substance abuse emerges from the interplay of a variety of genetic and environmental influences. Major questions addressed include whether risk is disorder-specific, how to distinguish between correlational and causal genetic and evironmental factors, sex differences in risk, and how risk and protective factors interact over time. The book also summarizes the conceptual underpinnings of the study and describes key methodological challenges and innovations.
Genetics Of Psychopathology
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Author : David Rosenthal
language : en
Publisher: McGraw-Hill Companies
Release Date : 1971
Genetics Of Psychopathology written by David Rosenthal and has been published by McGraw-Hill Companies this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Behavior genetics categories.
Psychopathology In The Genome And Neuroscience Era
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Author : Charles F. Zorumski
language : en
Publisher: American Psychiatric Pub
Release Date : 2007-05-03
Psychopathology In The Genome And Neuroscience Era written by Charles F. Zorumski and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-03 with Medical categories.
The fascinating Psychopathology in the Genome and Neuroscience Era brings together selected topics in psychiatric genetics, epidemiology and prevention, and neuroscience and education. This key reference integrates this information across the fields of genetics, epidemiology, and neuroscience to arrive at an understanding of where recent advances in genetics and neuroscience -- advances that promise to enhance our understanding of human behavior and psychopathology -- are likely to influence psychopathology research and education in the near future. How will the field of psychopathology incorporate the coming avalanche of information generated by these recent advances? The answer will influence not only how mental health professionals diagnose and treat patients but also how the next generation of professionals is trained. Chapters in this exciting compilation are based on individual talks by 20 international experts at the conceptual forefront of their respective fields given at the March 2003 American Psychopathological Association annual meeting. Organized into four main sections -- the future of psychiatric genetics, diagnosis and prevention of psychiatric disorders, neurobiology and psychiatric disorders, and the future of psychiatric education -- Psychopathology in the Genome and Neuroscience Era focuses on a broad range of topics: The importance of a conceptual shift from identifying major genes for mental disorders to gaining an understanding of the role of which genes in which contexts, both biological and environmental, confer susceptibility to or protection from mental disorders or components thereof Historical perspective of gene susceptibility to mental disorders, with the same possibilities for use and misuse of genotype data as now exist for significantly heritable traits such as intelligence, and for borderline traits such as criminal behavior and alcoholism Reconceptualization of medicine and medical diagnoses to include molecular genetic components, including the importance of cell loss and neurogenesis in mood disorders Major phenotypic problems inherent in all attempts to measure psychopathology, starting with how to achieve reliability, and how to advance from reliability to validity in future revisions of DSM and ICD classifications Brain structural abnormalities in mood disorders; physiological cell death and whether or not this natural phenomenon can be converted into a pathological process, including the importance of cell loss and neurogenesis in mood disorders The influence of scientific advances, workforce issues, and educational trends on psychiatric training Psychopathology in the Genome and Neuroscience Era is a must-read reference work for anyone -- practitioners, residents, and students alike -- interested in the future of psychiatric genetics, epidemiology, and education.
Gene Environment Interactions In Developmental Psychopathology
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Author : Kenneth A. Dodge
language : en
Publisher: Guilford Press
Release Date : 2011-09-01
Gene Environment Interactions In Developmental Psychopathology written by Kenneth A. Dodge and has been published by Guilford Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Psychology categories.
Bringing together foremost experts, this book reviews groundbreaking gene–environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed.
Gene Environment Transactions In Developmental Psychopathology
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Author : Patrick H. Tolan
language : en
Publisher: Springer
Release Date : 2017-04-29
Gene Environment Transactions In Developmental Psychopathology written by Patrick H. Tolan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-29 with Psychology categories.
This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.
Developmental Psychopathology And Wellness
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Author : James J. Hudziak
language : en
Publisher: American Psychiatric Pub
Release Date : 2009-02-20
Developmental Psychopathology And Wellness written by James J. Hudziak and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-20 with Medical categories.
A major benchmark in the understanding of psychiatric illness in children and adolescents, Developmental Psychopathology and Wellness reports on progress in identifying genetic and environmental influences on emotional-behavioral disorders. A team of 22 international authorities presents work that changes the way child psychiatry and clinical psychology are conceptualized, debunking misconceptions about depression, antisocial behavior, and other conditions to enhance our understanding of the causes of child psychopathology -- and improve the ways we treat these disorders. Coverage of basic principles describes the influence of genomic medicine, as explained by trailblazers in the field who demonstrate the importance of the developmental perspective. Chapters on gene-environment interaction review the important concepts of personality and temperament, cognition, and sex -- including findings from molecular genetic investigations on adolescent cognition, temperament, and brain function. Disorder-based examples show how emotional-behavioral illness and wellness attest to the interaction of genetic and environmental factors over time, providing new insight into the study of anxious depression, ADHD, autism, and antisocial personality disorders. And in considering how we can bridge the gap between research and clinical applications, Dr. Hudziak describes his family-based gene-environment approach as a means of better understanding etiopathology and treatment. Among the other significant contributions: Thomas Achenbach focuses on the importance of culture in understanding the genetic and environmental impact on children, with insights into measuring these sources of influence. Joan Kaufman reports on her seminal work on the genetic and environmental modifiers of risk and resilience in child abuse, relating maltreatment to other forms of environmental risk, genetic mediation, and reactivity. D. I. Boomsma describes the genetic architecture of childhood worry, presenting data from an extraordinary sample of 30,000 twin pairs. Frank Verhulst draws on a 14-year study to detail the advantages of the developmental perspective in understanding antisocial behavior. Stephen Faraone offers guidelines for moving beyond statistics to document the functional significance of DNA variants associated with psychopathology. As the contributors ably demonstrate, these new approaches to the care and treatment of at-risk children are applicable to daily practice, teaching, and research. Developmental Psychopathology and Wellness shows that these psychopathologies are not a matter of nature versus nurture or genes versus environment, but rather an intertwining web of them all.
Behavior Genetics Principles
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Author : Lisabeth F. DiLalla
language : en
Publisher: Amer Psychological Assn
Release Date : 2004
Behavior Genetics Principles written by Lisabeth F. DiLalla and has been published by Amer Psychological Assn this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Psychology categories.
Behavior Genetics Principles: Perspectives in Development, Personality, and Psychopathology presents work that addresses both historical and novel approaches to the study of genetic and environmental influences on behavior. Contributors to this volume use behavior genetics as a means for understanding the etiology of mental illness as well as normal development. They ask: what genes predispose a person to develop a specific personality trait? What about an inclination to a psychological disorder? How do environmental factors enhance or mute genetic factors? Do they regulate inherited individual differences in behavior and personality throughout a lifetime? Behavior Genetics Principles explores the many connections between genes, personality, development, and psychopathology. It focuses on research influenced by Irving I. Gottesman, a pioneer in behavioral genetics research. As a mentor and a colleague, Gottesman has worked to examine the role of genes and environmental factors using both traditional and novel study designs and analytic methods. This stimulating volume, by colleagues who have helped shape the field of behavioral genetics, presents cutting edge work that carries on h
Psychiatric Genetics And Genomics
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Author : Peter McGuffin
language : en
Publisher: Oxford University Press
Release Date : 2004-09-23
Psychiatric Genetics And Genomics written by Peter McGuffin and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-23 with Medical categories.
From reviews of the hardback:'It is timely to see such an excellent textbook... Aimed at graduate level students, this book is complex enough to be thorough, but clear with enough background to be accessible... the coverage is comprehensive and the flow logical... The text is uniformly well written and achieves a successful integration.' -The Lancet'A good introduction and reference book for professionals interested in psychiatric genetics such as psychiatrists, clinical psychologists and neuroscientists... the book you want to have on your bookshelf to look up material and obtain a complete and balanced picture of the field.' -Psychological MedicineRevised for paperback edition, with new appendicesGenetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations.The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future.The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors.Readership: Psychiatrists, clinical psychologists, geneticists, neuroscientists and neurologists