Genome Editing Tools And Gene Drives
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Genome Editing Tools And Gene Drives
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Author : Reagan Mudziwapasi
language : en
Publisher: CRC Press
Release Date : 2021-10-18
Genome Editing Tools And Gene Drives written by Reagan Mudziwapasi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-18 with Medical categories.
Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption. Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing tools Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)
Genome Editing Tools And Gene Drives
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Author : Reagan Mudziwapasi
language : en
Publisher:
Release Date : 2021-10-19
Genome Editing Tools And Gene Drives written by Reagan Mudziwapasi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-19 with Gene editing categories.
This book succinctly reviews and describes genome editing tools such as ZFNs, CRISPR, megaTALs and TALENs. It covers the history, principles, applications and the advantages and disadvantages of each tool. The book provides an approachable outline enhancing science education in schools and universities by demystifying genome editing technologies.
Genome Editing
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Author : Gurbachan S. Miglani
language : en
Publisher:
Release Date : 2019-04-30
Genome Editing written by Gurbachan S. Miglani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with Technology & Engineering categories.
"Genome editing: A Comprehensive Treatise provides concise knowledge on genetic manipulation of genome, accomplished in nuclear as well as organellar genomes. Basic principles of genome editing involve induction of double-stranded DNA breaks, with the help of engineered sit-specific thereby induce site-specific deletions, insertions, disruptions, etc. Hence, it is developed under the broader approach of genome engineering. This book is specially designed as a textbook and reference book, as well. The book will be useful for upper undergraduate and graduate students studying genome editing in agricultural, veterinary and medicinal universities. Teachers and researchers in many disciplines will also get benefited from this book. Salient features: DNA repair mechanisms involved in genome editing discussed. Different types of oligonucleotides and animals and plant viruses that have been modified to act as donor DNA molecules described. Detailed discussions on Gene drives, gene expression control, safety issues, regulatory issues and future of genome-editing technology. Include 2530 references, 50 tables and 261 figures. Problems listed at the end of each chapter"--Back cover.
New Genome Editing Tools And Resources Enabling Gene Discovery And Functional Genomics
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Author : Feng Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-01
New Genome Editing Tools And Resources Enabling Gene Discovery And Functional Genomics written by Feng Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.
Gene Drives On The Horizon
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-08-28
Gene Drives On The Horizon written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-28 with Science categories.
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Genome Editing
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Author : Shabir Hussain Wani
language : en
Publisher: Springer Nature
Release Date : 2022-11-08
Genome Editing written by Shabir Hussain Wani and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-08 with Science categories.
Over the last few decades, various techniques have been developed to alter the properties of plants and animals. While the targeted transfer of recombinant DNA into crop plants remains a valuable tool to achieve a desirable breeding outcome, integration of transgenes into the host genome has been random, which in part, leads to reduced acceptance of GMOs by the general population in some parts of the world. Likewise, methods of induced mutagenesis, such as TILLING, have the disadvantage that many mutations are induced per plant, which has to be removed again by expensive backcrossing. Advances in genome sequencing have provided more and more information on differences between susceptible and resistant varieties, which can now be directly targeted and modified using CRISPR/Cas9 technology. By selecting specific gRNAs occurrence of off-target modifications are comparatively low. ZFNs and TALENs- based approaches required re-engineering a new set of assembled polypeptides for every new target site for each experiment. The difficulty in cloning and protein engineering prevented these tools from being broadly adopted by the scientific community. Compared to these technologies, designing the CRISPR toolbox is much simpler and more flexible. CRISPR/Cas9 is versatile, less expensive and highly efficient. It has become the most widely used technology for genome editing in many organisms. Since its inception as a powerful genome-editing tool in late 2012, this breakthrough technology has completely changed how science is performed. The first few chapters in this book introduce the basic concept, design and implementation of CRISPR/Cas9 for different plant systems. They are followed by in-depth discussions on the legal and bio-safety issues accompanying commercialization and patenting of this emerging technology. Lastly, this book covers emerging areas of new tools and potential applications. We believe readers, novice and expert alike, will benefit from this all-in-one resource on genome editing for crop improvement. Chapter 17 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
The Crispr Cas Tool Kit For Genome Editing
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Author : Aftab Ahmad
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
The Crispr Cas Tool Kit For Genome Editing written by Aftab Ahmad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Medical categories.
This book discusses CRISPR/Cas- one of the most powerful tools available to scientists for genome editing. CRISPR/Cas is not only a genome editing tool, but researchers have also engineered it for gene regulation, genome imaging, base editing and epigenome regulations. This book describes the entire toolkit for CRISPR/Cas. The opening section gives an introduction to the technique and compares it with other genome editing tools. Further section gives a historical perspective of the tool, along with its detailed classification. The next chapters describe bioinformatic tools in CRISPR/Cas, and delivery methods for CRISPR/Cas. The book also discusses about the applications of CRISPR/Cas beyond genome editing and use of CRISPR for rewriting genetic codes. The book dedicates a section to the use of CRISPR in plants. The book culminates with a chapter on the current status, challenges and shortcomings of the CRISPR/Cas genome editing tool. The book would be highly interesting to students and researchers in molecular biology, biochemistry, biotechnology, food science, agriculture and plant sciences.
Modern Tools For Genetic Engineering
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Author : Michael Kormann
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-05-18
Modern Tools For Genetic Engineering written by Michael Kormann and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-18 with Science categories.
Site-specific endonucleases create double-strand breaks within the genome and can be targeted to literally any genetic mutation. Together with a repair template, a correction of the defective locus becomes possible. This book offers insight into the modern tools of genome editing, their hurdles and their huge potential. A new era of in vivo genetic engineering has begun.
Applications Of Genome Modulation And Editing
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Author : Paul John Verma
language : en
Publisher: Springer Nature
Release Date : 2022-06-13
Applications Of Genome Modulation And Editing written by Paul John Verma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-13 with Science categories.
This volume details generation of gene-edited cell lines and organisms as models for human diseases, pest control, and large animal welfare and production outcomes. Chapters guide readers through gene regulation, editing, screening of cell lines, genome editing, and an overview of the tools for efficient genome editing including; ZFNs, TALENs, and CRISPR. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step- by-step, readily reproducible protocols. Authoritative and cutting-edge, Applications of Genome Modulation and Editing aims to be a useful and practical guide for researchers to commence or advance their study in this field.
Crispr Cas9 Based Genome Editing For Treating Genetic Disorders And Diseases
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Author : Luis María Vaschetto
language : en
Publisher: CRC Press
Release Date : 2022-01-31
Crispr Cas9 Based Genome Editing For Treating Genetic Disorders And Diseases written by Luis María Vaschetto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Mathematics categories.
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.