Genomic Applications In Pathology
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Genomic Applications In Pathology
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Author : George Jabboure Netto
language : en
Publisher: Springer
Release Date : 2018-12-10
Genomic Applications In Pathology written by George Jabboure Netto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-10 with Medical categories.
The recent advances in genomics are continuing to reshape our approach to diagnostics, prognostics and therapeutics in oncologic and other disorders. A paradigm shift in pharmacogenomics and in the diagnosis of genetic inherited diseases and infectious diseases is unfolding as the result of implementation of next generation genomic technologies. With rapidly growing knowledge and applications driving this revolution, along with significant technologic and cost changes, genomic approaches are becoming the primary methods in many laboratories and for many diseases. As a result, a plethora of clinical genomic applications have been implemented in diagnostic pathology laboratories, and the applications and demands continue to evolve rapidly. This has created a tremendous need for a comprehensive resource on genomic applications in clinical and anatomic pathology. We believe that our current textbook provides such a resource to practicing molecular pathologists, hematopathologists and other subspecialized pathologists, general pathologists, pathology and other trainees, oncologists, geneticists and a growing spectrum of other clinicians. With periodic updates and a sufficiently rapid time from submission to publication, this textbook will be the resource of choice for many professionals and teaching programs. Its focus on genomics parallels the evolution of these technologies as primary methods in the clinical lab. The rapid evolution of genomics and its applications in medicine necessitates the (frequent) updating of this publication. This text will provide a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays will be discussed together with issues related to reporting and the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms will be detailed. Genomic applications in pharmacogenomics, inherited genetic diseases and infectious diseases will also be discussed. The latest iteration of practice recommendations or guidelines in genomic testing put forth by stakeholder professional organizations such as the College of American Pathology and the Association for Molecular Pathology, will be discussed as well as regulatory issues and laboratory accreditation related to genomic testing. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.
Genomic Applications In Pathology
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Author : George Jabboure Netto
language : en
Publisher: Springer
Release Date : 2014-09-16
Genomic Applications In Pathology written by George Jabboure Netto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-16 with Medical categories.
Genomic Applications in Pathology provides a state-of-the art review of the scientific principles underlying next generation genomic technologies and the required bioinformatics approaches to analyses of the daunting amount of data generated by current and emerging genomic technologies. Implementation roadmaps for various clinical assays such as single gene, gene panels, whole exome and whole genome assays are discussed together with issues related to reporting, including the pathologist’s role in interpretation and clinical integration of genomic tests results. Genomic applications for site-specific solid tumors and hematologic neoplasms are detailed, as well as genomic applications in pharmacogenomics, inherited genetic diseases, and infectious diseases. The latest iteration of practice recommendations and guidelines in genomic testing, put forth by stakeholder professional organizations such as the Association for Molecular Pathology and the College of American Pathologists, are also discussed in the volume, as well as regulatory issues and laboratory accreditation related to genomic testing. Written by experts in the field, Genomic Applications in Pathology provides a comprehensive resource that is of great value to practicing molecular pathologists, hematopathologists, other subspecialized pathologists, general pathologists, pathology trainees, oncologists, and geneticists.
Molecular Pathology And The Dynamics Of Disease
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Author : Maika G. Mitchell
language : en
Publisher: Academic Press
Release Date : 2018-04-16
Molecular Pathology And The Dynamics Of Disease written by Maika G. Mitchell and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-16 with Law categories.
Molecular Pathology and the Dynamics of Disease bridges the basic science of, and primary clinical literature on, human disease. Topics covered include several major disease areas, such as inflammation and host response, vascular disease, obesity, weight regulation and appetite, cancer biology, drug development, and gene- and cell-based therapeutics that are all presented in a way that emphasizes the interplay between clinical care and investigation. As new technologies and techniques are constantly changing and laboratory scientists plays a critical role in validating data used by clinicians in diagnosing patients, this book provides a timely guide that includes a clinical, research and theory perspective. - Assimilates theoretical knowledge with practical lab work - Provides a needed clinical perspective, along with research and theory - Highlights the impact of basic science on the practice of medicine
Advances In Molecular Pathology 2024
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Author : Ahmad Abou Tayoun
language : en
Publisher: Elsevier Health Sciences
Release Date : 2024-10-05
Advances In Molecular Pathology 2024 written by Ahmad Abou Tayoun and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-05 with Medical categories.
Advances in Molecular Pathology reviews the year's most important findings and updates within the field in order to provide practitioners with the current clinical information they need to improve patient outcomes. A distinguished editorial board identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. - Contains 24 articles on such topics as chronic myelomonocytic leukemia; antimicrobial resistance marker detection and clinical interpretation/limitations; DPYD and the congenital DPD deficiency; FHIR genomic operations; AI in genomics; clinical value of molecular LDTs; and more. - Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice. - Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.
Human Population Genetics And Genomic Applications
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Author : Mr. Rohit Manglik
language : en
Publisher: EduGorilla Publication
Release Date : 2024-02-24
Human Population Genetics And Genomic Applications written by Mr. Rohit Manglik and has been published by EduGorilla Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-24 with Science categories.
Genomic variation is covered. Guides students to analyze population genetics, fostering expertise in human genomics through laboratory experiments and theoretical analysis.
Diagnostic Immunohistochemistry
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Author : David J Dabbs
language : en
Publisher: Elsevier Health Sciences
Release Date : 2010-01-29
Diagnostic Immunohistochemistry written by David J Dabbs and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-29 with Medical categories.
Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin’s lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today’s indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin’s lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.
Molecular Pathology
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Author : John M. S. Bartlett
language : en
Publisher: Cambridge University Press
Release Date : 2015-11-05
Molecular Pathology written by John M. S. Bartlett and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-05 with Medical categories.
Practical overview of current molecular techniques and their applications in each organ system, for practising and trainee pathologists.
Practical Skin Pathology A Diagnostic Approach E Book
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Author : James W Patterson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-05-07
Practical Skin Pathology A Diagnostic Approach E Book written by James W Patterson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-07 with Medical categories.
Practical Skin Pathology is the only dermatopathology reference that uses a systematic pattern recognition approach to help you achieve more accurate diagnoses of both neoplastic and non-neoplastic skin diseases. This volume in the Pattern Recognition Series helps you to efficiently and confidently evaluate even the most challenging skin diseases and lesions. Identify challenging types of skin cancer, including cutaneous lymphomas and melanocytic lesions, as well as non-neoplastic skin diseases such as panniculitis; drug eruptions, including reactions to newer chemotherapeutic agents; infectious diseases; and many more, with the only dermatopathology reference that uses a pattern recognition approach. Progress logically from the histologic pattern, through the appropriate workup, around the pitfalls, to the best diagnosis. Compare your clinical findings to more than 1,400 full-color, high-quality photos that capture the characteristic presentation of a full range of dermatopathology specimens.
Breast Pathology E Book
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Author : David J Dabbs
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-05-19
Breast Pathology E Book written by David J Dabbs and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-19 with Medical categories.
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. - Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. - Incorporates the latest classifications of breast pathology and molecular diagnosis. - Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. - Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. - Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. - Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. - Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. - Includes biomarker guideline updates throughout. - Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
Cell And Tissue Based Molecular Pathology E Book
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Author : Raymond R. Tubbs
language : en
Publisher: Elsevier Health Sciences
Release Date : 2008-09-22
Cell And Tissue Based Molecular Pathology E Book written by Raymond R. Tubbs and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-22 with Medical categories.
This volume in the Foundations in Diagnostic Pathology Series packs today's most essential cell and tissue base molecular pathology into a compact, high-yield format! It focuses on the state of the art in practical validated molecular diagnostics as applied across the fields of surgical pathology and cytology. With an emphasis on current, clinically valid, and diagnostically important applications today and in the near future, you can be assured you’re getting the most up-to-date, authoritative coverage available. Its pragmatic, well-organized approach, nearly 250 full-color illustrations, and at-a-glance boxes and tables make the information you need easy to access. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice! Offers detailed discussions on today’s technologies to help you select the best test for case evaluation. Presents recognized molecular pathologists who convey the most current information, keeping you on the cusp of your field. Features nearly 250 full-color illustrations that present important pathologic features, enabling you to form a differential diagnosis and compare your findings with actual cases. Uses a consistent, user-friendly format, including at-a-glance boxes and tables for easy reference.