Genomics Ii
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Evolution Of The Human Genome Ii
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Author : Naruya Saitou
language : en
Publisher: Springer
Release Date : 2022-05-29
Evolution Of The Human Genome Ii written by Naruya Saitou and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-29 with Science categories.
This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing “Non-neutral Evolution on Human Genes” (Part I) and “Evolution of Modern Human Populations” (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety of populations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.
Comparative Genomics
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Author : Nicholas H. Bergman
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-29
Comparative Genomics written by Nicholas H. Bergman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-29 with Medical categories.
This volume provides a collection of robust protocols for molecular biologists studying comparative genomics. Given the tremendous increase in available biosequence data over the past ten years, this volume is timely, comprehensive, and novel. The volume is intended for molecular biologists, biochemists and geneticists.
Genomics Ii
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Author : Iconcept Press
language : en
Publisher: CreateSpace
Release Date : 2013-10
Genomics Ii written by Iconcept Press and has been published by CreateSpace this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10 with Medical categories.
Genomics is the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. It is a discipline in genetics that applies recombinant DNA, DNA sequencing methods, and bioinformatics to sequence, assemble, and analyze the function and structure of genomes. Genomics II - Bacteria, Viruses and Metabolic Pathways is the second volume of our Genomics series. There are totally three volumes in this series. Chapter 1 describes an analysis and statistical scoring approach for cellular assay data based on single-cell information. In Chapter 2, the concept of metabolic pathways analysis is introduced. The mathematic principle of extreme pathway and elementary flux mode are compared. Chapter 3 is dedicated to the Pathway- and Network-based analysis of the high-throughput genomic data. The author introduced Reactome FI Cytoscape plugin that can construct a network based on the list of genes of interest, cluster the constructed network, and annotate network modules based on pathways and Gene Ontology terms. Chapter 4 provides a review of microarray and RNA-seq techniques for high-throughput gene expression measurements, discusses the strategies and issues of high-level analysis on gene expression data, and introduces a new algorithm for analyzing microarray data. Chapter 5 summarizes our current understanding of the intracellular defenses by APOBEC family against invading nucleic acids including endogenous retroelements that make up more than 40% of the mammalian genome. Chapter 6 discusses immunoinformatics software that can be employed to study the evolution of antigenic epitopes. Chapter 7 discusses the integration of retroviral genome into host DNA, which is a critical step in the life cycle of a retrovirus. The authors developed an assay using some target DNA sequences from common MLV integration sites in the genome of murine lymphomas and an HIV-1 integration site in the genome of T cell integrated into the target DNA in vitro. Chapter 8 discusses how microarray can be as a promising new technology for broad-spectrum pathogen detection, making it possible to test for the presence of thousands of viruses simultaneously. Chapter 9 discusses the origin of the unilateral aminoacylation specificity based on mt SerRS as a typical example. Mitochondrial (mt) aminoacyl-tRNA synthetases (aaRSs) are able to charge both mt and bacterial cognate tRNAs, whereas most bacterial synthetases including serine (Ser) are only able to charge bacterial cognate tRNAs, whose phenomenon is termed unilateral aminoacylation specificity between mitochondria and bacteria. In Chapter 10, the authors chosen Cytoplasmic polyhedrosis virus (CPV) and hepatitis B virus (HBV) to demonstrate how we can using structural biology techniques to explore the viral genome, such as genome package and distribution, and mRNA transcribing/capping/releasing of viruses. Chapter 11 provides an overview of the steps required to correctly perform the genotypic resistance test; a detailed description of computational programs used for the interpretation of this assay is reported. Chapter 12 discusses Influenza C virus, which is a member of the Orthomyxoviridae, a family comprising viruses with segmented single-stranded RNA genomes of negative polarity. Chapter 13 provides comprehensive essential genes of Streptococcus sanguinis and compares them among streptococcal species. A model has been created to predict essential genes in bacteria. Chapter 14 discusses Lactobacillus casei Zhang, which was a new probiotic bacterium isolated from traditional home-made koumiss in Inner Mongolia of China. Chapter 15 discusses how the association of comparative genome analysis and protein structure prediction methods could help in high-throughput genome analysis aiming the structure-based rational drug design.
Genetics And Genomics Of Eye Disease
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Author : Xiaoyi Raymond Gao
language : en
Publisher: Academic Press
Release Date : 2019-09-12
Genetics And Genomics Of Eye Disease written by Xiaoyi Raymond Gao and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-12 with Science categories.
Genetics and Genomics of Eye Disease: Advancing to Precision Medicine thoroughly examines the latest genomics methods for studying eye disease, including complex eye disorders associated with multiple genes. GWAS, WES, WGS, RNA-sequencing, and transcriptome analysis as employed in ocular genomics are discussed in-depth, as are genomics findings tied to early-onset glaucoma, strabismus, age-related macular degeneration, adult-onset glaucoma, diabetic retinopathy, keratoconus, and leber congenital amaurosis, among other diseases. Research and clinical specialists offer guidance on conducting preventative screenings and counseling patients, as well as the promise of machine learning, computational statistics and artificial intelligence in advancing ocular genomics research. Offers thorough guidance on conducting genetic and genomic studies of eye disease Examines the genetic basis of a wide range of complex eye diseases and single-gene and Mendelian disorders Discusses the application of genetic testing and genetic risk prediction in eye disease diagnosis and patient counseling
Genome The Autobiography Of A Species In 23 Chapters
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Author : Matt Ridley
language : en
Publisher: HarperCollins UK
Release Date : 2017-04-27
Genome The Autobiography Of A Species In 23 Chapters written by Matt Ridley and has been published by HarperCollins UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-27 with Science categories.
The most important investigation of genetic science since The Selfish Gene, from the author of the critically acclaimed and best-selling The Red Queen and The Origins of Virtue.
Clinical Genomics
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Author : Shashikant Kulkarni
language : en
Publisher: Academic Press
Release Date : 2014-11-10
Clinical Genomics written by Shashikant Kulkarni and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-10 with Science categories.
Clinical Genomics provides an overview of the various next-generation sequencing (NGS) technologies that are currently used in clinical diagnostic laboratories. It presents key bioinformatic challenges and the solutions that must be addressed by clinical genomicists and genomic pathologists, such as specific pipelines for identification of the full range of variants that are clinically important. This book is also focused on the challenges of diagnostic interpretation of NGS results in a clinical setting. Its final sections are devoted to the emerging regulatory issues that will govern clinical use of NGS, and reimbursement paradigms that will affect the way in which laboratory professionals get paid for the testing. Simplifies complexities of NGS technologies for rapid education of clinical genomicists and genomic pathologists towards genomic medicine paradigm Tried and tested practice-based analysis for precision diagnosis and treatment plans Specific pipelines and meta-analysis for full range of clinically important variants
Handbook Of Statistical Genomics
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Author : David J. Balding
language : en
Publisher: John Wiley & Sons
Release Date : 2019-07-09
Handbook Of Statistical Genomics written by David J. Balding and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-09 with Science categories.
A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.
Computational And Statistical Approaches To Genomics
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Author : Wei Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-26
Computational And Statistical Approaches To Genomics written by Wei Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-26 with Science categories.
The second edition of this book adds eight new contributors to reflect a modern cutting edge approach to genomics. It contains the newest research results on genomic analysis and modeling using state-of-the-art methods from engineering, statistics, and genomics. These tools and models are then applied to real biological and clinical problems. The book’s original seventeen chapters are also updated to provide new initiatives and directions.
Discovering Genomics Proteomics And Bioinformatics
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Author : A. Malcolm Campbell
language : en
Publisher: Benjamin-Cummings Publishing Company
Release Date : 2007
Discovering Genomics Proteomics And Bioinformatics written by A. Malcolm Campbell and has been published by Benjamin-Cummings Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Computers categories.
Discovering Genomics is the first genomics text that combines web activities and case studies with a problem-solving approach to teach upper-level undergraduates and first-year graduate students the fundamentals of genomic analysis. More of a workbook than a traditional text, Discovering Genomics, Second Edition allows students to work with real genomic data in solving problems and provides the user with an active learning experience. The companion website at www.aw-bc.com/geneticsplace is regularly updated to keep up with changes to online databases. The Second Edition has been thoroughly revised and updated to incorporate the latest scientific findings on popular topics such as disease-causing organisms and genetic defects. Case study chapters have been placed throughout the book to tie real-life scenarios into the concepts that follow. Two of the book's key pedagogical features, Discovery Questions and Math Minutes, have also been updated and expanded. The interactive companion website has been reprogrammed with JMOL, the latest 3-D software used to view DNA structures.
Adoption Of Artificial Intelligence In Human And Clinical Genomics Volume Ii
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Author : Li Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-21
Adoption Of Artificial Intelligence In Human And Clinical Genomics Volume Ii written by Li Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-21 with Science categories.
Large databases are created by genomics for the discovery, study, and development of novel treatments all around the world. It's not hard to conceive that artificial intelligence (AI) might currently study the 3 billion base pairs that make up humanoid genetic makeup in order to uncover genetic disparities among the population. By 2026, large pharmaceutical companies hope to have researched up to 2 million genomes and analyzed massive amounts of patient data from clinical drug studies. As new equipment is introduced, AI will be employed in genomics for a variety of omics investigations, including transcriptomics. To aid in the classification of potentially clinically significant genes, AI is used to combine data from genomic research with literature analysis. Machine learning is now a critical component of the genomics industry's growth. AI and Machine learning in genomics is already having an impact on a number of areas, including genetic testing, medical care delivery, and genomics accessibility for people interested in learning more about how their genes influence their health. The purpose of this research is to explore AI and Machine learning applications in gene technology and their roles in paving the way for future genomics machine learning applications.