Genomics Proteomics And Vaccines


Genomics Proteomics And Vaccines
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Genomics Proteomics And Vaccines


Genomics Proteomics And Vaccines
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Author : Guido Grandi
language : en
Publisher: John Wiley & Sons
Release Date : 2004-08-13

Genomics Proteomics And Vaccines written by Guido Grandi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-13 with Science categories.


While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly. Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens. This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions



Post Genomic Approaches In Drug And Vaccine Development


Post Genomic Approaches In Drug And Vaccine Development
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Author : Kishore R. Sakharkar
language : en
Publisher: CRC Press
Release Date : 2022-09-01

Post Genomic Approaches In Drug And Vaccine Development written by Kishore R. Sakharkar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-01 with Science categories.


Over the past decade, genome sequencing projects and the associated efforts have facilitated the discovery of several novel disease targets and the approval of several innovative drugs. To further exploit this data for human health and disease, there is a need to understand the genome data itself in detail, discover novel targets, understand their role in physiological pathways and associated diseases, with the aim to translate these discoveries to clinical and preventive medicine. It is equally important to understand the labors and limitations in integrating clinical phenotypes with genomic, transcriptomic, proteomic and metabolomic approaches. T



Bioinformatics For Vaccinology


Bioinformatics For Vaccinology
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Author : Darren R. Flower
language : en
Publisher: John Wiley & Sons
Release Date : 2008-10-13

Bioinformatics For Vaccinology written by Darren R. Flower and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-13 with Medical categories.


“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.



Omics Approaches And Technologies In Covid 19


Omics Approaches And Technologies In Covid 19
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Author : Debmalya Barh
language : en
Publisher: Academic Press
Release Date : 2022-12-01

Omics Approaches And Technologies In Covid 19 written by Debmalya Barh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-01 with Medical categories.


The COVID-19 pandemic has affected the entire world in an unprecedented way since 2019. However, novel and innovative applications of various omics, computational, and smart technologies have helped manage the pandemic of the 21st century in a very effective manner. Omics approaches and technologies in COVID-19 presents up-to-date knowledge on omics, genetic engineering, mathematical and computational approaches, and advanced technologies in the diagnosis, prevention, monitoring, and management of COVID-19. This book contains 26 chapters written by academic and industry experts from more than 15 countries. Split into three sections (Omics; Artificial Intelligence and Bioinformatics; and Smart and Emerging Technologies), it brings an overview of novel technologies under omics such as, genomic, metagenomic, pangenomic, metabolomics and proteomics in COVID-19. In addition, it discusses hostpathogen interactions and interactomics, management options, application of genetic engineering, mathematical modeling andsimulations, systems biology, and bioinformatics approaches in COVID-19 drug discovery and vaccine development. This is a valuable resource for students, biotechnologists, bioinformaticians, virologists, clinicians, and pharmaceutical, biomedical, and healthcare industry people who want to understand the promising omics and other technologies used in combating COVID-19 from various aspects. Provides novel technologies for rapid diagnostics, drug discovery, vaccine development, monitoring, prediction of future waves, etc. Describes various omics applications including genomics, metagenomics, epigenomics, nutrigenomics, transcriptomics,miRNAomics, proteomics, metabolomics, phenomics, multiomics, etc., in COVID-19 Presents applications of genetic engineering, CRISPR, artificial intelligence, mathematical and in silico modeling, systems biology,and other computational approaches in COVID-19 Discusses emerging, digital, and smart technologies for the monitoring and management of COVID-19



Challenges In Delivery Of Therapeutic Genomics And Proteomics


Challenges In Delivery Of Therapeutic Genomics And Proteomics
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Author : Ambikanandan Misra
language : en
Publisher: Elsevier
Release Date : 2010-09-09

Challenges In Delivery Of Therapeutic Genomics And Proteomics written by Ambikanandan Misra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-09 with Science categories.


Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed



Proteomics Biomedical And Pharmaceutical Applications


Proteomics Biomedical And Pharmaceutical Applications
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Author : Hubert Hondermarck
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08

Proteomics Biomedical And Pharmaceutical Applications written by Hubert Hondermarck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Medical categories.


Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.



Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents


Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents
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Author : Vito G. DelVecchio
language : en
Publisher: IOS Press
Release Date : 2003

Applications Of Genomics And Proteomics For Analysis Of Bacterial Biological Warfare Agents written by Vito G. DelVecchio and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Bacterial diseases categories.




Reverse Vaccinology


Reverse Vaccinology
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Author : Jayashankar Das
language : en
Publisher: Elsevier
Release Date : 2024-05-30

Reverse Vaccinology written by Jayashankar Das and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Computers categories.


Reverse Vaccinology: Concept, Methods and Advancement presents the development strategy of new vaccines through genome sequencing bioinformatics analysis. Reverse vaccinology promises to revolutionize vaccine development, especially for pathogens to which the classical applications of Pasteur’s principles have failed, and it is explained in detail in this book.The book is split into three sections: the first, Concept, brings the basis of reverse vaccinology, vaccine antigen discovery, and subunit vaccine; the second, Tools and Methods, describes immunoinformatic, proteomics for epitope-vaccine design, data bases, network analysis, machine learning, and NGS driven antigen screening technology; and the last one, Disease Case Study, discusses real-world examples in the development of new vaccines for diverse diseases.It is a valuable resource for bioinformaticians, researchers, students, and member of the biomedical and medical fields who want to learn more about a new and agile process for the development of new vaccines. Explains the fundamentals of reverse vaccinology and how it can save time in the development of new vaccines Focuses on efforts to develop a vaccine candidate against various pathogens using computational approaches Presents databases and web servers for conducting reverse vaccinology Describes the screening process of potential vaccine candidates through machine learning



Short Views On Insect Genomics And Proteomics


Short Views On Insect Genomics And Proteomics
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Author : Chandrasekar Raman
language : en
Publisher: Springer
Release Date : 2015-12-10

Short Views On Insect Genomics And Proteomics written by Chandrasekar Raman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-10 with Science categories.


Entomology is a super science, embracing interdisciplinary approaches in genomics, proteomics, and interdependent fields of biochemistry, physiology, molecular entomology, and biotechnology. An urgent need to manage available resources for the benefit of the planet and humankind has led to remarkable progress since publication of the fruit fly genome in 2000. “Short Views on Insect Genomics and Proteomics” presents multiple perspectives of recognized experts from around the world in genomics, bioinformatics, molecular biology, biochemistry, physiology, and immunology, emphasizing fast-moving areas of current research on insects and other arthropods. Concise, accessible, topical reviews include body lice and white fly genome projects, aphid phenotypic plasticity, insect regulatory genomics, the complex tick sialome, protein expression systems, therapeutic potential of insect antimicrobial peptides, nanoparticle insecticides, and novel uses for recombinant and synthetic spider silks.



Immunoproteomics


Immunoproteomics
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Author : Kelly M. Fulton
language : en
Publisher: Humana Press
Release Date : 2013-08-21

Immunoproteomics written by Kelly M. Fulton and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-21 with Medical categories.


Providing current diverse approaches and techniques used to study the immunoproteome, Immunoproteomics: Methods and Protocols collects chapters from key researchers that deliver information to be used in diagnostics, disease progression, and vaccine correlates of protection analysis, to name but a few. This detailed volume includes techniques used for the study of the antibody targets of bacterial pathogens, viruses, and cancer, mass spectrometry-based approaches to characterize T-cell epitopes, chapters on detection and relative quantification of cytokines in serum, as well as in silico prediction of epitopes using sequence-based or modeling approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Immunoproteomics: Methods and Protocols aids researchers in transferring these techniques to their own laboratories in addition to providing a reference to guide researchers toward appropriate techniques.