Global Host Proteomic Responses To Virus Infection
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Global Host Proteomic Responses To Virus Infection
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Author : Kevin Coombs
language : en
Publisher: Frontiers E-books
Release Date :
Global Host Proteomic Responses To Virus Infection written by Kevin Coombs and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The field of virology has seen explosive growth in the past few decades. A large amount of effort has gone into successfully delineating virus evolution, genetic diversity, immunology, pathogenesis, structure, vaccine development, viral gene expression and genomic replication strategies. In addition, considerable recent work has been focusing on cellular responses to infection as well as how viruses may induce transformation and oncogenesis. Viruses are obligate intracellular parasites and thus absolutely dependent upon host cells. Not surprisingly, they often cause profound changes in cells, including apoptosis, death and signalling, to name a few perturbations. Thus, the molecular signals for how viruses induce pathophysiological alterations in their hosts have been of growing recent interest. Cellular and organismal responses, such as those induced by virus infection, are invariably mediated by changes in gene and protein expression and modification. Thus, there has been keen interest in understanding how gene and protein expressions and modifications are quantitatively and qualitatively affected by such challenges. From a historical perspective, most early work that examined host protein responses to virus infection employed “biased” approaches, in which investigators targeted a limited number, or only one cellular molecule of interest. Completion of many organisms’ genome sequences has allowed the global “non-biased” simultaneous analysis of the entire repertoire of cellular mRNA species, the transcriptome, by gene micro-arrays. This has provided significant information about how cellular gene expressions are altered by virus-induced perturbations, but has not provided as much information about the encoded proteins. This results for several reasons, including, but not limited to the fact that gene expression levels cannot accurately predict protein expression levels, nor the types and extent of post-translational modifications, many genes encode multiple proteins through splice variants, and protein activity may be affected by a large number of conditions, including phosphorylation. Recent technological and bioinformatic approaches make it now possible to begin to extend similar global analyses to probe the cellular proteome, the repertoire of the actual effector molecules. One general strategy has been to take advantage of improved separations technologies, as well as greatly improved mass spectrometry resolution, to quantitatively or comparatively measure hundreds or thousands of proteins. Proteins from multiple conditions (i.e., mock-infected and infected) may be differentially labelled by various techniques, such as 2D-DIGE, ICAT, iTRAQ, SILAC, with 18O during peptide preparation, and/or by various other methods, and then compared to measure comparative alterations in the levels of proteins induced by the virus infection. Such analyses have also been extended by using “label-free” methods for more efficient multiplexing applications, and/or by examining specific protein modifications. In addition, concerted efforts to raise antibodies against all cellular proteins have resulted in the development of “antibody arrays,” which are also generally used for quantitative or comparative assays. Finally, while assays, such as the above, are generally limited to delineating the absolute amount of specific proteins, newer technologies have been developed that allow the simultaneous probing of hundreds of proteins’ functions. Assays, such as “Activity Based Protein Profiling”, are designed to probe enzymatic activity, with current focus on broad-spectrum proteases and other enzymatic classes. This Research Topic will provide an overview of many of these methods, as well as numerous specific examples of each approach, and how they are used to better delineate the ways viruses affect cellular responses during infection.
Proteomics Approaches To Unravel Virus Vertebrate Host Interactions
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-04-30
Proteomics Approaches To Unravel Virus Vertebrate Host Interactions written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-30 with Science categories.
Proteomics Approaches to Unravel Virus - Vertebrate Host Interactions, Volume 109 in the Advances in Virus Research series, highlights state-of-the art mass spectrometry techniques to elucidate the tight interplay of vertebrate viruses and their host cells. The volume includes chapters on Spatio-temporal resolution of host protein complexes during virus entry, Proteomic approaches to investigate gammaherpesvirus biology and associated tumorigenesis, Applications of Mass Spectrometry Imaging in Virus Research, Mapping surfaceome dynamics during viral infection, Characterization of proteolytic events in virus-host interactions, Dynamic protein network modulation upon viral infection, and much more. Discusses the latest methodological breakthroughs in mass spectrometry-based proteomics Reviews how technology has advanced our knowledge on virus-host interactions Provides future perspectives on proteomics research in virology
Rna Viruses
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Author : Decheng Yang
language : en
Publisher: World Scientific
Release Date : 2009
Rna Viruses written by Decheng Yang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection.
The Baculoviruses
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Author : Lois K. Miller
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Baculoviruses written by Lois K. Miller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The past decade has witnessed an explosion of information on the molecular biology of insect viruses and a frenzy of activity in applying this information to medicine and agriculture. Genetically engineered baculoviruses are presently being tested for commercial use as pesticides, and the study of such viruses is also revealing remarkable insights into basic cellular processes such as apoptosis. This comprehensive volume provides readers with knowledge of basic and applied baculovirology so that current literature in the field can be appreciated.
Experimental Models Of Multiple Sclerosis
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Author : Ehud Lavi
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-03
Experimental Models Of Multiple Sclerosis written by Ehud Lavi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-03 with Medical categories.
Multiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It’s aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it.
Human Influenza New Insights For The Healthcare Professional 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Human Influenza New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Human Influenza: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Human Influenza in a compact format. The editors have built Human Influenza: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Human Influenza in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Human Influenza: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Sustainable Agriculture Reviews 59
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Author : Vinod Kumar Yata
language : en
Publisher: Springer Nature
Release Date : 2023-02-07
Sustainable Agriculture Reviews 59 written by Vinod Kumar Yata and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-07 with Technology & Engineering categories.
The dependency on animal biotechnology in livestock industries has been increased in the recent past. The livestock production research has witnessed remarkable developments on biotechnological methods to produce the elite animal breeds. The global animal food requirement has been steadily increasing, and animal production needs to be increased as per the global needs. This book covers various aspects of animal biotechnology such as, reproductive biotechnologies in sheep and goats, oogenesis and folliculogenesis and ovarian disorders. This book focusses the discussion on proteomics and metabolomics, and separate chapters were dedicated to discuss these topics. The proteomics studies of animal viruses were discussed in this book, and this would be helpful to understand animal viral pathogenesis. The applications of metabolomics in livestock were discussed with focus on data analysis, identification of unknown compounds. The purpose of this book is to provide the recent research trends, and convert all this information to usable guide to professionals, researchers and students who are working the research area of animal biotechnology.
Cell Biology
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Author : Stevo Najman
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-01-20
Cell Biology written by Stevo Najman and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-20 with Science categories.
Cell biology is a multidisciplinary scientific field that its modern expansion in new knowledge and applications owes to important support of new technologies with the rapid development, such as ICTs. By integrating knowledge from nano-, molecular, micro-, and macroareas, it represents a strong foundation for almost all biological sciences and disciplines, as well as for biomedical research and application. This book is a compilation of inspiring reviews/original studies, which are divided into sections: New Methods in Cell Biology, Molecular and Cellular Regulatory Mechanisms, and Cellular Basis of Disease and Therapy. The book will be very useful for students and beginners to gain insight into new area, as well as for experts and scientists to find new facts and expand their scientific horizons through biological sciences and biomedicine.
Plant Viruses
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Author : Rajarshi Kumar Gaur
language : en
Publisher: CRC Press
Release Date : 2018-01-12
Plant Viruses written by Rajarshi Kumar Gaur and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-12 with Science categories.
Plant viruses are significant as they affect our food supply and are capable of rapidly spreading to new plant species, so a comprehensive study of plant viruses is important in understanding their pathogenesis and prevention. This book focuses on the plant virus evolution, their molecular classification, epidemics and management. The key features in the book includes genome organization, translation and replication, virus-coded proteinases, structure of virus particles, cell receptors and host range, the RNA polymerase, quasispecies dynamics and virus evolution, and its natural habitats.
Genetics And Evolution Of Infectious Diseases
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Author : Michel Tibayrenc
language : en
Publisher: Elsevier
Release Date : 2017-01-12
Genetics And Evolution Of Infectious Diseases written by Michel Tibayrenc and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-12 with Medical categories.
Genetics and Evolution of Infectious Diseases, Second Edition, discusses the constantly evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world. Students in public health, biomedical professionals, clinicians, public health practitioners, and decisions-makers will find valuable information in this book that is relevant to the control and prevention of neglected and emerging worldwide diseases that are a major cause of global morbidity, disability, and mortality. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases during the last century, in recent decades the world has witnessed a worldwide human immunodeficiency virus (HIV) pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. The economic, social, and political burden of infectious diseases is most evident in developing countries which must confront the dual burden of death and disability due to infectious and chronic illnesses. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field of infectious disease