Glutathione Transferases And Gamma Glutamyl Transpeptidases
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Glutathione Transferases And Gamma Glutamyl Transpeptidases
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Author : Helmut Sies
language : en
Publisher: Gulf Professional Publishing
Release Date : 2005-11-22
Glutathione Transferases And Gamma Glutamyl Transpeptidases written by Helmut Sies and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-22 with Science categories.
Focuses on particular aspects of the so-called Phase II of drug detoxication, which has important ramifications for endogenous metabolism and nutrition. This volume on glutathione transferases and gamma-glutamyl transpeptidases serves to bring together methods and concepts in a rapidly developing field of cell and systems biology.
Gamma Glutamyl Transpeptidases
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Author : Immacolata Castellano
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-09
Gamma Glutamyl Transpeptidases written by Immacolata Castellano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-09 with Science categories.
Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.
Glutathione Transferases And Gamma Glutamyl Transpeptidases
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Author :
language : en
Publisher: Academic Press
Release Date : 2005-12-06
Glutathione Transferases And Gamma Glutamyl Transpeptidases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-06 with Science categories.
This volume on glutathione transferases and gamma-glutamyl transpeptidases serves to bring together current methods and concepts in an interesting, important and rapidly developing field of cell and systems biology. It focuses on particular aspects of the so-called Phase II of drug detoxication, which has important ramifications for endogenous metabolism and nutrition. This volume of Methods in Enzymology presents current knowledge and in this field of research. Together with the volumes on Quinones and Quinone Enzymes (volumes 378 and 382), and on Phase II Conjugation Enzymes and Transport Systems (volume 400), the state of knowledge on proteomics and metabolomics of many pathways of (waste) product elimination, enzyme protein induction and gene regulation and feedback control is provided. We trust that this volume will help stimulate future investigations and speed the advance of knowledge in systems biology. *A laboratory standard for more than 40 years *Over 400 volumes strong *Also available on ScienceDirect
Functions Of Glutathione In Liver And Kidney
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Author : H. Sies
language : en
Publisher: Springer
Release Date : 2011-11-15
Functions Of Glutathione In Liver And Kidney written by H. Sies and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-15 with Medical categories.
The serene phrase, Lest I forget thee, glutathione ... , coined by the Kosowers (1) to describe the state in the 1960's, must be replaced now by something like "Inevitable GSH" in order to characterize the current situation. The surge in interest on the ubiquitous tripeptide has been ama zing, with publications on GSH running at rates as high as one per day, so that it seemed appropriate to convene international experts for a discussion of recent develop ments this year. Unlike the two previous meetings in this decade held in Tlibingen in 1973 (2) and in santa Ynez in 1975 (3), the scope was restricted to Functions of Gluta thione in Liver and Kidney. Only in this way did an in-depth discussion of the current state of knowledge in a limit ed topic appear possible. The last couple of years have seen a fascinating pro ductivity in the fields of (a) Regulation of the Glutathione Level in the Liver, (b) Role of y-Glutamyltransferase in Gluta thione Turnover with emphasis on the renal enzyme, and a critical appraisal of the y-Glutamyl Cycle, (c) Hyd:roperox ide and Disulfide Metaholism, enriched by the discovery of the nonseleniurn-dependent glutathione peroxidase activ ity and its relation to the glutathione-S-transferases, and the participation of the 2GSH/GSSG system in redox transitions in intact organ, cells and isolated mito chondria, and (d) a multitude of Pharmacological and Toxi cological Aspects related to glutathione, mainly centered on the events leading to liver damage and the protective
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Plant Glutathione Transferases Diverse Multi Tasking Enzymes With Yet To Be Discovered Functions
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Author : Jolán Csiszár
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-05
Plant Glutathione Transferases Diverse Multi Tasking Enzymes With Yet To Be Discovered Functions written by Jolán Csiszár and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-05 with categories.
Dictionary Of Toxicology
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Author : Ernest Hodgson
language : en
Publisher: Academic Press
Release Date : 2014-10-08
Dictionary Of Toxicology written by Ernest Hodgson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-08 with Medical categories.
Dictionary of Toxicology, Third Edition presents a compendium of definitions of all current toxicological terminology. This authoritative reference illustrates and describes words, concepts, acronyms and symbols for both the toxicological theory and applied risk assessment, as well as providing guidance on the correct selection of problematic, similar and frequently-misused terms. Written by one of the world’s foremost experts in toxicology, and with each entry peer reviewed, Dictionary of Toxicology, Third Edition is an essential reference for all scientific, medical and legal professionals who work with or encounter the toxicological effects of contaminants on biological systems. New to this edition: an update on every entry and the inclusion of all terminology and concepts relating to molecular toxicology, nanotoxicology and computational toxicology. Presents peer-reviewed definitions on the most up-to-date toxicological terms and concepts. New edition includes definitions within the fields of molecular toxicology, nanotoxicology, computational toxicology and risk assessment.
Organic Xenobiotics And Plants
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Author : Peter Schröder
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-08
Organic Xenobiotics And Plants written by Peter Schröder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-08 with Science categories.
Natural and agro-ecosystems are frequently exposed to natural or synthetic substances, which, while they have no direct nutritional value or significance in metabolism, may negatively affect plant functioning. These, xenobiotics, may originate from both natural (fires, volcano eruptions, soil or rock erosion, biodegradation) and anthropogenic (air and soil pollution, herbicides) sources. And, while affected plants have only a limited number of possibilities for avoiding accumulation of these compounds, they do exhibit several enzymatic reactions for detoxification including oxidation, reduction, hydrolysis and conjugation reactions. In agro-ecosystems in particular these mechanisms have great significance in relation to herbicide detoxification and tolerance. In this volume an international group of experts present an overview of the nature and distribution of organic xenobiotics, including their uptake, effects on plant functioning and detoxification mechanisms. The particular significance of glutathione S-transferases in bio-indication and bio-monitoring, and in the detoxification of volatile organic air pollutants and herbicides is evaluated, and their potential significance in phytoremediation and bioaccumulation will be discussed. This volume will be of interest to a wide audience, from graduate students to senior researchers in a wide range of disciplines including plant ecology, plant biochemistry, agriculture and environmental management. It will also be of practical interest to environmentalists, policy makers and resource managers.
Permuted Medical Subject Headings
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1978
Permuted Medical Subject Headings written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Subject headings categories.
Physician S Guide To The Diagnosis Treatment And Follow Up Of Inherited Metabolic Diseases
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Author : Nenad Blau
language : en
Publisher: Springer
Release Date : 2014-07-08
Physician S Guide To The Diagnosis Treatment And Follow Up Of Inherited Metabolic Diseases written by Nenad Blau and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
This book, combining and updating two previous editions, is a unique source of information on the diagnosis, treatment, and follow-up of metabolic diseases. The clinical and laboratory data characteristic of rare metabolic conditions can be bewildering for both clinicians and laboratory personnel. Reference laboratory data are scattered, and clinical descriptions may be obscure. The Physician’s Guide documents the features of more than five hundred conditions, grouped according to type of disorder, organ system affected (e.g. liver, kidney, etc) or phenotype (e.g. neurological, hepatic, etc). Relevant clinical findings are provided and pathological values for diagnostic metabolites highlighted. Guidance on appropriate biochemical genetic testing is provided. Established experimental therapeutic protocols are described, with recommendations on follow-up and monitoring. The authors are acknowledged experts, and the book will be a valuable desk reference for all who deal with inherited metabolic diseases.