Glycans In Cell Interaction And Recognition
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Glycans In Cell Interaction And Recognition
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Author : Michele Aubrey
language : en
Publisher: CRC Press
Release Date : 2002-01-17
Glycans In Cell Interaction And Recognition written by Michele Aubrey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-17 with Science categories.
Glycoproteins play an important role in the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Over the last decade, research has highlighted the therapeutic implications of glycoproteins for many physiological and pathological processes, such as inflammation, arthritis and metastasis. The first part of the book d
Essentials Of Glycobiology
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Author : Ajit Varki
language : en
Publisher:
Release Date : 1999-01-01
Essentials Of Glycobiology written by Ajit Varki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Science categories.
Glycobiology has its roots in the nineteenth century, when chemists first began to analyze sugar and polysaccharides. Advances in this area continued at a steady rate during most of this century, but the past 20 years has witnessed an unparalleled explosion of new knowledge that has transformed the field. This monograph contains the basic information needed to understand the field of glycobiology along with the most current work at the forefront of the field.
Transforming Glycoscience
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2012-10-23
Transforming Glycoscience written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-23 with Science categories.
A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Functional Ultrastructure
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Author : Margit Pavelka
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-16
Functional Ultrastructure written by Margit Pavelka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-16 with Science categories.
The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization. a plethora of new information on the structure of cells This information is vital to current work in which that was coupled to and followed by biochemical and the emphasis is on integrating approaches from functional studies. TEM was king and each micrograph proteomics, molecular biology, genetics, genomics, of a new object produced new information that led to molecular imaging and physiology and pathology to novel insights on cell and tissue organization and their understand cell functions and derangements in disease. functions. The quality of data represented by the images In this current era, there is a growing tendency to of cell and tissues had been perfected to a very high level substitut e modern light microscopic techniques for by the great microscopists of that era including Palade, electron microscopy, because it is less technically Porter, Fawcett, Sjostrand, Rhodin and many others. At demanding and is more readily available to researchers- present, the images that we see in leading journals for This atlas reminds us that the information obtained by the most part do not reach the same technical level and electron microscopy is invaluable and has no substitute.
The Glycome
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Author : Adeel Malik
language : en
Publisher: CRC Press
Release Date : 2021-07-07
The Glycome written by Adeel Malik and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-07 with Science categories.
This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
The Sugar Code
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Author : Hans-Joachim Gabius
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-19
The Sugar Code written by Hans-Joachim Gabius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-19 with Science categories.
A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
The Role Of Glycans In Immune Cell Functions
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Author : Jasmeen S. Merzaban
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-26
The Role Of Glycans In Immune Cell Functions written by Jasmeen S. Merzaban and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-26 with categories.
Glycans represent a major constituency of post-translational modifications that occur on most, if not all, proteins. Whether on mammalian or invertebrate cell surfaces, they exist as sugar chain moieties designed from the exquisite and coordinated activity of cell-specific glycosylation. Some of the more common glycan structures are linked to cell surface polypeptides via an asparagine (N)-linked residue or a serine/threonine (O)-linked residue, along with a notable contingent found linked to ceramides in the lipid bilayer known as glycosphingolipids. These glycans can associate with complementary glycan-binding proteins (GBP) or lectins to mediate and translate this carbohydrate recognition to cell function. In immunity, there is increasing evidence that precise immune cell glycans are recognized by corresponding GBPs in a cell-intrinsic or -extrinsic manner. Unique carbohydrate recognition domains within GBPs are comprised of precisely spaced amino acid functional groups that allow for selective engagement of a particular glycan target. This structure-function relationship is present in immune signaling pathways, whereby glycans and GBPs on the surface of immune cells (and non-immune cells) help control processes such as immune cell activation, recognition of pathogens, suppression and tissue-specific migration. The diversity of glycan structures and glycosylation among individual immune cell subsets is controlled by the expression of genes involved in glycan biosynthesis including glycosyltransferases, glycosidases, glycan-precursor biosynthetic enzymes and nucleotide-sugar transporters. These genes represent more than 3% of the human genome, and cell-specific expression of these genes dictates a cell’s glycan repertoire, ultimately influencing its molecular interactions with GBPs. Altogether, these emerging lines of investigation highlight the regulatory capacity of glycans in immune health and disease, which in turn, pave the way for novel diagnostic, prognostic, and therapeutic strategies.
Glycosylation And Glycation In Health And Diseases
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Author : Tapan Kumar Mukherjee, Parth Malik, Ruma Rani
language : en
Publisher: Bentham Science Publishers
Release Date : 2025-03-21
Glycosylation And Glycation In Health And Diseases written by Tapan Kumar Mukherjee, Parth Malik, Ruma Rani and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-21 with Science categories.
Glycosylation and Glycation in Health and Diseases provides a comprehensive exploration of the essential biochemical processes, their implications in physiology, and their role in disease progression. This book is divided into two key sections: the first focuses on glycosylation, an enzymatic process essential for cellular function, while the second covers glycation, a nonenzymatic reaction linked to aging and chronic diseases. It covers congenital glycosylation disorders, the biology of advanced glycation end products (AGEs), and the critical role of the receptor for AGEs (RAGE) in inflammatory, neurological, cardiovascular, and cancer-related conditions. A valuable resource for students, researchers, and industry professionals, this book highlights the significance of glycobiology in drug discovery, diagnostics, and therapeutic innovations. Key Features: - Covers fundamental and advanced concepts of glycosylation and glycation. - Discusses the role of glycans in cellular function and disease pathology. - Explores AGE-RAGE interactions in cardiovascular, pulmonary, and neurological disorders. - Highlights applications in biopharmaceuticals, diagnostics, and vaccine development.
International Review Of Cell And Molecular Biology
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Author : Kwang W. Jeon
language : en
Publisher: Academic Press
Release Date : 2014-01-07
International Review Of Cell And Molecular Biology written by Kwang W. Jeon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-07 with Science categories.
International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2012: 4.973. - Authored by some of the foremost scientists in the field - Provides comprehensive reviews and current advances - Wide range of perspectives on specific subjects - Valuable reference material for advanced undergraduates, graduate students and professional scientists
Glycobiology Of Innate Immunology
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Author : Cheorl-Ho Kim
language : en
Publisher: Springer Nature
Release Date : 2022-03-31
Glycobiology Of Innate Immunology written by Cheorl-Ho Kim and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Science categories.
This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.