Glycosylation Analysis Of Immunoglobulin G

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Glycosylation Analysis Of Immunoglobulin G

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Author : Maurice Henricus Johnannes Selman
language : en
Publisher:
Release Date : 2012

Glycosylation Analysis Of Immunoglobulin G written by Maurice Henricus Johnannes Selman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.

Antibody Glycosylation

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Author : Marija Pezer
language : en
Publisher: Springer Nature
Release Date : 2021-10-22

Antibody Glycosylation written by Marija Pezer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Medical categories.

This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Immunoglobulin Glycosylation Analysis State Of The Art Methods And Applications In Immunology

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Author : Irena Trbojević-Akmačić
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-14

Immunoglobulin Glycosylation Analysis State Of The Art Methods And Applications In Immunology written by Irena Trbojević-Akmačić and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-14 with Medical categories.

Capillary Gel Electrophoresis

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Author : Andras Guttman
language : en
Publisher: Newnes
Release Date : 2021-12-04

Capillary Gel Electrophoresis written by Andras Guttman and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-04 with Science categories.

Capillary Gel Electrophoresis and Related Microseparation Techniques covers all theoretical and practical aspects of capillary gel electrophoresis. It also provides an excellent overview of the key application areas of nucleic acid, protein and complex carbohydrate analysis, affinity-based methodologies, micropreparative aspects and related microseparation methods. It not only gives readers a better understanding of how to utilize this technology, but also provides insights into how to determine which method will provide the best technical solutions to particular problems. This book can also serve as a textbook for undergraduate and graduate courses in analytical chemistry, analytical biochemistry, molecular biology and biotechnology courses. Covers all theoretical and practical aspects of capillary gel electrophoresis Excellent overview of the key applications of nucleic acid, protein and complex carbohydrate analysis, affinity-based methodologies, micropreparative aspects and related microseparation methods Teaches readers how to use the technology and select methods that are ideal for fundamental problems Can serve as a textbook for undergraduate and graduate courses in analytical chemistry, analytical biochemistry, molecular biology and biotechnology courses

Abnormalities Of Igg Glycosylation And Immunological Disorders

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Author : D. A. Isenberg
language : en
Publisher:
Release Date : 1996-07-25

Abnormalities Of Igg Glycosylation And Immunological Disorders written by D. A. Isenberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-07-25 with Health & Fitness categories.

Glycobiology has become the focus of considerable research in recent years as the role of oligosaccharides in both health and disease has come under scrutiny. During this period particular emphasis has been placed on the glycosylation of human immunoglobulins, notably IgG, not least because clear links with a restricted range of human diseases has been established. Abnormalities of IgG Glycosylation and Immunological Disorders uniquely draws together the facts that have emerged to link abnormalities in IgG glycosylation and immunological disease, especially rheumatoid arthritis. It reviews all aspects of immunoglobulin glycosylation abnormalities, including the structural anatomy of glycoproteins; the methods used to analyse them; the clinical aspects of glycobiology in both human disease and animal models; the glycosylation enzymes and the genes that encode and regulate these enzymes; and the possible pathogenicity of IgG. The chapter authors have been chosen because of the original contributions they have made to this exciting field of research. As such this authoritative and well referenced volume will be indispensable to both clinicians and basic scientists with an interest in glycosylation, as well as rheumatologists, immunologists, bacteriologists and glycobiologists.

Characterization Of The Glycosylation Of A Human Immunoglobulin M

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Author : Thomas J. Monica
language : en
Publisher:
Release Date : 1994

Characterization Of The Glycosylation Of A Human Immunoglobulin M written by Thomas J. Monica and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.

Site Specific N Glycosylation Analysis Of A Glycoprotein Hormone And Sialylation Dependence Of Igg Antibody Pharmakokinetics

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Author : Robert Wilmanowski
language : en
Publisher:
Release Date : 2016

Site Specific N Glycosylation Analysis Of A Glycoprotein Hormone And Sialylation Dependence Of Igg Antibody Pharmakokinetics written by Robert Wilmanowski and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Glycosylation Engineering Of Biopharmaceuticals

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Author : Alan Beck
language : en
Publisher: Humana Press
Release Date : 2013-03-09

Glycosylation Engineering Of Biopharmaceuticals written by Alan Beck and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.

Glyco-engineering is being developed as a method to control the composition of carbohydrates and to enhance the pharmacological properties of monoclonal antibodies (mAbs) and other proteins. In Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols, experts in the field provide readers with production and characterization protocols of glycoproteins and glyco-engineered biopharmaceuticals with a focus on mAbs. The volume is divided in four complementary parts dealing with glyco-engineering of therapeutic proteins, glycoanalytics, glycoprotein complexes characterization, and PK/PD assays for therapeutic antibodies. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols serves as an ideal guide for scientists striving to push forward the exciting field of engineered biopharmaceuticals.

Essentials Of Glycobiology

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Author : Ajit Varki
language : en
Publisher: CSHL Press
Release Date : 1999

Essentials Of Glycobiology written by Ajit Varki and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Therapeutic Antibody Engineering

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Author : William R Strohl
language : en
Publisher: Elsevier
Release Date : 2012-10-16

Therapeutic Antibody Engineering written by William R Strohl and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-16 with Medical categories.

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity