Grappling With The Multifaceted World Of The Dna Damage Response
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Grappling With The Multifaceted World Of The Dna Damage Response
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Author : Antonio Porro
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-10
Grappling With The Multifaceted World Of The Dna Damage Response written by Antonio Porro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-10 with categories.
DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.
Popular Mechanics
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Author :
language : en
Publisher:
Release Date : 2000-01
Popular Mechanics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01 with categories.
Popular Mechanics inspires, instructs and influences readers to help them master the modern world. Whether it’s practical DIY home-improvement tips, gadgets and digital technology, information on the newest cars or the latest breakthroughs in science -- PM is the ultimate guide to our high-tech lifestyle.
Biological Responses To Dna Damage
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Author :
language : en
Publisher: CSHL Press
Release Date : 2000
Biological Responses To Dna Damage written by and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
Living cells have evolved many ways of coping with metabolic events and environmental influences that damage DNA. These mechanisms, and the frequent progression to cancer that results when they go awry, are rev iewed in this volume by authors from over sixty of the world's leading laboratories. The topics discussed include DNA repair, mutagenesis and other damage-tolerance functions, checkpoint control, apoptosis, and adaptation. They draw from studies on human and yeast cells. Current, but with a valuable historical perspective, this volume has the depth and lasting value typical of this most prestigious series and is esse ntial reading for investigators of DNA replication, cell cycle control, and tumorigenesis.
Dna Damage Responses
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Author : Nima Mosammaparast
language : en
Publisher: Humana
Release Date : 2023-03-30
Dna Damage Responses written by Nima Mosammaparast and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Science categories.
This volume provides detailed methods and key approaches used to mechanistically study DNA damage, as well as the factors involved in the damage response. Chapters guide readers through proteomics and biophysical approaches, analyzing protein function, quantifying DNA replication dynamics and nucleic acid base damage, as well as biochemical reconstitution of key pathways involved in DNA repair. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, DNA Damage Responses: Methods and Protocols aims to be a useful practical guide to researches to help further their study in this field.
Dna Damage Response
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Author : Sean Bohen
language : en
Publisher:
Release Date : 2018
Dna Damage Response written by Sean Bohen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Cancer categories.
The Dna Damage Response Implications On Cancer Formation And Treatment
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Author : Kum Kum Khanna
language : en
Publisher: Springer
Release Date : 2009-11-18
The Dna Damage Response Implications On Cancer Formation And Treatment written by Kum Kum Khanna and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-18 with Medical categories.
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
A Microscopic Study Of The Dna Damage Response
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Author : Christoffel Dinant
language : en
Publisher:
Release Date : 2008
A Microscopic Study Of The Dna Damage Response written by Christoffel Dinant and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Analysis Of The Dna Damage Response In Living Cells
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Author : Oliver Mortusewicz
language : en
Publisher:
Release Date : 2007
Analysis Of The Dna Damage Response In Living Cells written by Oliver Mortusewicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.