Growth Hormone Therapy In Children And Adults
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Growth Hormone Therapy In Children And Adults
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Author :
language : en
Publisher:
Release Date : 2004
Growth Hormone Therapy In Children And Adults written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Genotropin
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Author : Pharmacia
language : en
Publisher:
Release Date : 1995
Genotropin written by Pharmacia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Growth Hormone Therapy In Pediatrics
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Author : Michael B. Ranke
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2007-01-01
Growth Hormone Therapy In Pediatrics written by Michael B. Ranke and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.
For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.
Current Indications For Growth Hormone Therapy
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Author : Peter C. Hindmarsh
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1999
Current Indications For Growth Hormone Therapy written by Peter C. Hindmarsh and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Breaking new ground in terms of scientific analysis, this book addresses the question of who benefits most from treatment with recombinant human growth hormone. Outlined at the beginning of this book are the principles of evidence-based medicine along with a critical appraisal of the statistical issues that lie at the center of growth hormone trials. Each chapter reviews the current state of knowledge on the use of growth hormone in conditions ranging from Turner syndrome through other syndromes of intrauterine growth retardation to the short normal child, also highlighting issues that remain to be addressed in further research. Evaluating therapies in terms of efficacy and safety or the health benefit for the individual or society as a whole are rarely approached in pediatric endocrinology and for this reason a special chapter on health economic evaluation is included. This book is of interest and offers practical help to pediatricians and endocrinologists.
Growth Hormone Deficiency In Adults
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Author : Jens O. L. Jørgensen
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Growth Hormone Deficiency In Adults written by Jens O. L. Jørgensen and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Science categories.
It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.
Challenges In Growth Hormone Therapy
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Author : John Monson
language : en
Publisher: Wiley-Blackwell
Release Date : 1999-08-10
Challenges In Growth Hormone Therapy written by John Monson and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-08-10 with Medical categories.
The area of growth hormone therapy has been shrouded in controversy for several years. In the US, anxious parents apply pressure on doctors so their little ones can receive this elixir, regardless of whether there is a medical condition to treat. More recently, health care organisations have balked at the very high cost of growth hormone therapy, and with a greater consciousness of evidence-based medicine, there is also growing concerns about its efficacy. There are now fears about the safety of long-term growth hormone administration with possible risks of increased cardiovascular disease and diabetes, although the latter seems to be a temporary phenomenon. At the clinical level there are also uncertainties about proper optimum dosing schedules used for both children and adults, as well as how to manage the transition from childhood to adulthood (when to stop giving the hormone and how to follow up). Challenges in Growth Hormone Therapy tackles these issues and provides a timely and controversial review of these topics for endocrinologists and paediatricians.
Growth Hormone Deficiency
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Author : Laurie E. Cohen
language : en
Publisher: Springer
Release Date : 2016-07-04
Growth Hormone Deficiency written by Laurie E. Cohen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-04 with Medical categories.
Providing the most current information on the function of human growth hormone (GH) and the consequences of its deficiency, this practical yet comprehensive text is divided into three sections. Part one describes the mechanisms of GH secretion and action, including the physiology of GH and its regulation by sex steroids and thyroid hormones, the effects of both under nutrition and obesity on GH secretion, and the metabolic effects of human recombinant GH therapy. The second section covers diagnostic strategies and tests for GH deficiency in both children and adults, including MRI of the pituitary. The final section describes the different etiologies of GH deficiency, from molecular mechanisms and gene abnormalities to cranial radiation and traumatic brain injury, along with syndromes related to this deficiency. Presenting underlying mechanisms and pathologies, as well as diagnostic methods, Growth Hormone Deficiency will provide the most up-to-date essential information and evidence on this condition for the clinical endocrinologist.
Human Growth Hormone
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Author : Roy G. Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2000-01-28
Human Growth Hormone written by Roy G. Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-01-28 with Medical categories.
In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.
Human Growth Hormone Treatment For Children With Prader Willi Syndrome
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Author : Rob Edge
language : en
Publisher:
Release Date : 2018
Human Growth Hormone Treatment For Children With Prader Willi Syndrome written by Rob Edge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Two previous CADTH reports examined the clinical effectiveness of human growth hormone (hGH) for Prader-Willi Syndrome (PWS) in adolescents and adults. These reports found that treatment with hGH results in improvement in body composition in patients with Prader-Willi syndrome and summarized evidence-based guidelines for the treatment of children and adults with PWS. The purpose of this report is to provide an update regarding the clinical effectiveness of hGH in pediatric PWS patients (0 to 19 years) and a summary of cost-effectiveness analyses and recent evidence-based guidelines.
Prader Willi Syndrome
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Author : Urs Eiholzer
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001
Prader Willi Syndrome written by Urs Eiholzer and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Over the past years, great advances have been made in the research of Prader-Willi Syndrome and its treatment options. The results raise hopes that the once depressing outlook for children with PWS and their parents will gradually give way to a much improved quality of life. Clinical research has shown that there is a hypothalamic growth hormone deficiency in PWS and that growth hormone treatment improves body composition, body proportions and physical performance of patients. Increased lean body mass enhances energy expenditure and - provided the energy input can be restrained - children no longer become obese. The disappearance of the obese phenotype in children with PWS who are treated with growth hormone starting before puberty prevents stigmatisation of children and their families in society. The mental retardation and the compulsive behavior disorder will however remain major handicaps which seemingly cannot be influenced by growth hormone therapy. This book provides an overview of the clinical research results as to hormones and metabolism of PWS with special emphasis on growth hormone and growth hormone treatment. Besides the outstanding scientific texts, this volume offers comprehensive photographic material to document the development of selected patients over several years and to illustrate extreme individual changes in the physical appearance and facial expression.