Growth Hormone Therapy In Pediatrics
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Growth Hormone Therapy In Pediatrics
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Author : Michael B. Ranke
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2007-01-01
Growth Hormone Therapy In Pediatrics written by Michael B. Ranke and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Medical categories.
For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.
Growth Hormone Therapy In Pediatrics
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Author : M.B. Ranke
language : en
Publisher:
Release Date : 2007
Growth Hormone Therapy In Pediatrics written by M.B. Ranke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.
Current Indications For Growth Hormone Therapy
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Author : Peter C. Hindmarsh
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1999
Current Indications For Growth Hormone Therapy written by Peter C. Hindmarsh and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Breaking new ground in terms of scientific analysis, this book addresses the question of who benefits most from treatment with recombinant human growth hormone. Outlined at the beginning of this book are the principles of evidence-based medicine along with a critical appraisal of the statistical issues that lie at the center of growth hormone trials. Each chapter reviews the current state of knowledge on the use of growth hormone in conditions ranging from Turner syndrome through other syndromes of intrauterine growth retardation to the short normal child, also highlighting issues that remain to be addressed in further research. Evaluating therapies in terms of efficacy and safety or the health benefit for the individual or society as a whole are rarely approached in pediatric endocrinology and for this reason a special chapter on health economic evaluation is included. This book is of interest and offers practical help to pediatricians and endocrinologists.
The Short Child
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Author : Paul Kaplowitz
language : en
Publisher: Hachette+ORM
Release Date : 2008-06-06
The Short Child written by Paul Kaplowitz and has been published by Hachette+ORM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-06 with Health & Fitness categories.
For the millions of parents concerned about their child's height, there is now an authoritative resource of comprehensive information to reassure and guide them in seeking help. This groundbreaking book by two of America's leading pediatric endocrinologists offers reliable guidance on the diagnosis and treatment of growth disorders, from helping parents determine whether their child's height is normal to understanding when it's necessary to seek the advice of a specialist. Parents will also learn about: The role of genetics, nutrition, and hormones in their child's growth The social and psychological impact of short stature Methods for estimating the height a child will be as an adult Important topics of concern to discuss with their child's doctors Medical conditions that cause short stature The most up-to-date research on treatment, including the controversial use of growth hormone-so you and your physician can decide what's right for your child.
Growth Hormones
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Author : Nobutake Matsuo
language : en
Publisher:
Release Date : 1997-12-31
Growth Hormones written by Nobutake Matsuo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-12-31 with Growth categories.
Growth Disorders
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Author : C. J. H. Kelnar
language : en
Publisher: Hodder Education
Release Date : 1998
Growth Disorders written by C. J. H. Kelnar and has been published by Hodder Education this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This book, written by internationally recognized experts in their respective disciplines, will provide comprehensive and up-to-date information about growth disorders for the practicing clinician who deals with children and adolescents. It will be a valuable reference source as well as a practical management guide for general and specialist paediatricians and endocrinologists. It would also be of interest to community and primary care health workers, as well as child and family psychiatrists.
Growth Hormone Related Diseases And Therapy
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Author : Ken Ho
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-08-12
Growth Hormone Related Diseases And Therapy written by Ken Ho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-12 with Medical categories.
The molecular era ushered in the cloning of the growth hormone (GH) gene and the production of unlimited amounts of GH through recombinant technology. The continuing momentum of research from basic science to clinical evaluation has brought unprecedented advances to the understanding of GH biology for the clinical endocrinologist. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician distills all the new information of relevance to the endocrinologist over the last 20 years by offering five sections: physiology, molecular genetics, GH deficiency, acromegaly and pharmacotherapy. The first section on physiology focuses on GH action. A review on the structure and function of the GH receptor is followed by a perspective on the regulatory role of ghrelin on GH secretion. The second section on genetics covers pituitary function and adenomas, including new and fascinating information on familial pituitary adenomas, their genotype and phenotype. The adult GH deficiency section spans the epidemiology and diagnosis of GH deficiency with a strong reminder for the clinician that the transition period represents a critical time of somatic maturation, which continues for years after cessation of liner growth. The section on acromegaly focuses on management, giving practical guides to the value of GH and IGF-1 measurements, the place of somatostatin analogues and of radiotherapy while reminding the reader as to why evaluating quality of life is an important part of management. Finally, the section on GH pharmacology takes the reader through innovative developments of long-acting GH formulations with some products on the threshold of clinical use. This section provides a balanced evidence based review of the effects of GH supplementation in aging and in sports where recent data indicates an enhancing effect on a selective aspect of performance. Growth Hormone Related Diseases and Therapy: A Molecular and Physiological Perspective for the Clinician integrates a wealth of information and will prove an invaluable reference for pediatric endocrinologists, adult endocrinologists, endocrine scientists and internists interested in the human biology of GH.
Growth Hormone Deficiency In Adults
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Author : Jens O. L. Jørgensen
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Growth Hormone Deficiency In Adults written by Jens O. L. Jørgensen and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Science categories.
It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.
Pediatric Endocrinology
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Author : Ora Hirsch Pescovitz
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2004
Pediatric Endocrinology written by Ora Hirsch Pescovitz and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
"Pescovitz and Eugster, both affiliated with the Section for Pediatric Endocrinology/Diabetology at Indiana University School of Medicine, provide essential information on the mechanisms, diagnosis, and management of pediatric endocrine disorders. Aspects of human development and physiology are combined with information on etiology, diagnosis, and treatment. Within each of the traditional endocrine systems, contemporary molecular genetics and developmental endocrinology are presented, followed by material on specific clinical disorders and therapeutic strategies. Interspersed throughout the book are chapters devoted to emerging issues such as childhood obesity, short stature, and treatment of children with disorders of sexual differentiation. B&w photos and diagnostic images are included. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com)"--[source inconnue].
Prader Willi Syndrome
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Author : Urs Eiholzer
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001
Prader Willi Syndrome written by Urs Eiholzer and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Over the past years, great advances have been made in the research of Prader-Willi Syndrome and its treatment options. The results raise hopes that the once depressing outlook for children with PWS and their parents will gradually give way to a much improved quality of life. Clinical research has shown that there is a hypothalamic growth hormone deficiency in PWS and that growth hormone treatment improves body composition, body proportions and physical performance of patients. Increased lean body mass enhances energy expenditure and - provided the energy input can be restrained - children no longer become obese. The disappearance of the obese phenotype in children with PWS who are treated with growth hormone starting before puberty prevents stigmatisation of children and their families in society. The mental retardation and the compulsive behavior disorder will however remain major handicaps which seemingly cannot be influenced by growth hormone therapy. This book provides an overview of the clinical research results as to hormones and metabolism of PWS with special emphasis on growth hormone and growth hormone treatment. Besides the outstanding scientific texts, this volume offers comprehensive photographic material to document the development of selected patients over several years and to illustrate extreme individual changes in the physical appearance and facial expression.