Guide To Targeted Therapies Egfr Mutations In Nsclc

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Guide To Targeted Therapies Egfr Mutations In Nsclc

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Author : Federico Cappuzzo
language : en
Publisher: Springer
Release Date : 2014-09-25

Guide To Targeted Therapies Egfr Mutations In Nsclc written by Federico Cappuzzo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-25 with Medical categories.

Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.

Guide To Targeted Therapies Treatment Resistance In Lung Cancer

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Author : Federico Cappuzzo
language : en
Publisher: Springer
Release Date : 2015-10-15

Guide To Targeted Therapies Treatment Resistance In Lung Cancer written by Federico Cappuzzo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-15 with Medical categories.

This text is a concise and up-to-date review, which discusses the background, development and mechanisms of resistance, testing methods and technology, current and emerging therapies and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of treatment resistance in lung cancer as well as a summary of current therapies will benefit from this succinct guide.

Egfr Directed Therapy In Lung Cancer

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Author : So Yeon Kim
language : en
Publisher: Cambridge University Press
Release Date : 2023-01-26

Egfr Directed Therapy In Lung Cancer written by So Yeon Kim and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-26 with Medical categories.

Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

Fast Facts Non Small Cell Lung Cancer

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Author : M. O'Brien
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2022-03-16

Fast Facts Non Small Cell Lung Cancer written by M. O'Brien and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-16 with Medical categories.

Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy, and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases

Overcoming Resistance To Egfr Inhibitors In Egfr Mutant Nsclc

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Author : Anthony Faber
language : en
Publisher: Academic Press
Release Date : 2023-01-30

Overcoming Resistance To Egfr Inhibitors In Egfr Mutant Nsclc written by Anthony Faber and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-30 with Science categories.

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Fast Facts Non Small Cell Lung Cancer

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Author : Mary O'Brien
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2016-08-22

Fast Facts Non Small Cell Lung Cancer written by Mary O'Brien and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-22 with Medical categories.

Rapid developments in the classification, screening and treatment of non-small-cell lung cancer (NSCLC) are improving outcomes for patients with the disease. This insightful guide is designed to bring you up to speed with recent advances, including: • the latest CT-based screening and interval growth imaging techniques • proposed changes to the TNM classification system • the increasing trend for minimally invasive and lung-sparing surgery • stereotactic radiation for early-stage tumors • new targeted therapies • breakthroughs in personalized medicine. Today's developments will change tomorrow's standards of care. 'Fast Facts: Non-Small-Cell Lung Cancer' is important reading for all health professionals and medical trainees working in this fast-moving area.

Advances In Systemic Therapy For Non Small Cell Lung Cancer An Issue Of Thoracic Surgery Clinics

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Author : Jessica Donington
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-05-11

Advances In Systemic Therapy For Non Small Cell Lung Cancer An Issue Of Thoracic Surgery Clinics written by Jessica Donington and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-11 with Medical categories.

This issue of Thoracic Surgery Clinics, guest edited by Drs. Jyoti Patel and Jessica Donington, is devoted to Advances in Systemic Therapy for Non-Small Cell Lung Cancer. Drs. Patel and Donington have assembled expert authors to review the following topics: Adjuvant and Neoadjuvant Immunotherapy; Combining Immunotherapy with Radiation in Lung Cancer; Adjuvant Chemotherapy; ALK Mutations; Molecular Targets Beyond the Big 3; Advances in Systemic Therapy; Liquid Biopsies in NSCLC; Combining Immunotherapy and Chemotherapy for NSCLC; ROS-1 Mutations; EGFR Mutations; and more!

Molecular Pathology Of Lung Cancer

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Author : Philip T. Cagle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-14

Molecular Pathology Of Lung Cancer written by Philip T. Cagle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-14 with Medical categories.

As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.

Comprehensive Guide To Malignant Neoplasms Heart Mediastinum And Pleura

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Author : Dr. Spineanu Eugenia
language : en
Publisher: Dr. Spineanu Eugenia
Release Date : 2024-03-03

Comprehensive Guide To Malignant Neoplasms Heart Mediastinum And Pleura written by Dr. Spineanu Eugenia and has been published by Dr. Spineanu Eugenia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-03 with Medical categories.

Unlock the knowledge you need to understand and navigate the complex world of malignant neoplasms affecting the heart, mediastinum, and pleura with our comprehensive guide. In this meticulously crafted treatise, we delve deep into the intricacies of these rare and challenging cancers, providing you with a wealth of information, insights, and the latest advancements in medical science. What to Expect: In-Depth Insights: Explore the anatomy of the heart, mediastinum, and pleura, gaining a profound understanding of how these organs function and how cancer can impact them. Cellular Basis of Cancer: Dive into the molecular and cellular mechanisms underlying the development of malignant neoplasms, empowering you with knowledge about the disease at its core. Holistic Health: Discover how holistic approaches can enhance the care of cancer patients, encompassing nutrition, psychosocial support, and quality of life considerations. Cutting-Edge Research: Stay up-to-date with the latest research in the field, including precision medicine, immunotherapies, and emerging technologies that are reshaping cancer diagnosis and treatment. Patient-Centered Care: Learn about patient-centered approaches that prioritize shared decision-making, survivorship care, and palliative support to enhance the well-being of patients and their families. Global Collaboration: Understand the importance of global collaboration, data sharing, and policy advocacy in the fight against these rare cancers. Whether you're a medical professional seeking comprehensive insights or a patient or caregiver looking to better understand and manage these challenging conditions, this treatise is your invaluable resource. With a focus on clarity, accessibility, and the latest SEO optimization techniques, we ensure that this guide is not only informative but also easily discoverable by those who need it most.

Protein Kinase Inhibitors As Sensitizing Agents For Chemotherapy

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Author :
language : en
Publisher: Academic Press
Release Date : 2018-11-21

Protein Kinase Inhibitors As Sensitizing Agents For Chemotherapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-21 with Medical categories.

Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment