Haemostatic Drugs
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Haemostatic Drugs
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Author : M. Verstraete
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Haemostatic Drugs written by M. Verstraete and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
clinical efficacy of haemostatic agents had to be published work and had to fulftl most of the following minimum requirements: (1) Quantitation ofthe measured blood loss was required, and not merely a clinical impression of the amount of blood lost, if the document pertained to a planned but «open» clinical trial. (2) Only double-blind trials with random allocation of the placebo and experimental drug to preselected patients were considered suitable for discussion, if the blood loss had not been quantitated in a prospective trial. (3) Defmition and appropriate selection of patients admitted to the trial: all inclusion and exclusion criteria used to select patients had to be mentioned in detail. (4) Once included in the trial, patients could be withdrawn only on the basis of strict criteria for withdrawal which had been defined in advance. (5) A double-blind trial had to be continued for an adequate length of time if the haemostatic agent was being assessed in the prevention of bleeding in patients with a long lasting bleeding disorder . (6) A clear and detailed statistical analysis of the results was required. Moreover, a clear distinction between the therapeutic and prophylactic value of the haemostatic agent had to be made and applied separately to the group of patients without any major basic disorder and those with a bleeding disorder e.g. : chronic thrombocytopenia, haemophilia, Rendu-Osler telangiectasia ... General statements not substantiated by experimental data, even when issued by well-known authorities, were not considered a reasonable basis for discussion.
Haemostatic Drugs
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Author : M. Verstraete
language : en
Publisher:
Release Date : 1977
Haemostatic Drugs written by M. Verstraete and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Anticoagulant Drugs
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Author : Mojca Božič-Mijovski
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-08-29
Anticoagulant Drugs written by Mojca Božič-Mijovski and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with Medical categories.
Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.
Drugs In Relation To Blood Coagulation Haemostasis And Thrombosis
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Author : Gustav V. R. Born
language : en
Publisher:
Release Date : 1968
Drugs In Relation To Blood Coagulation Haemostasis And Thrombosis written by Gustav V. R. Born and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Anticoagulants (Medicine) categories.
Drugs In Relation To Blood Coagulation Haemostasis And Thrombosis
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Author : Maurício Rocha e Silva
language : en
Publisher:
Release Date : 1968
Drugs In Relation To Blood Coagulation Haemostasis And Thrombosis written by Maurício Rocha e Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with Pharmacology categories.
Efficacy Of Fda Approved Hemostatic Drugs To Improve Survival And Reduce Bleeding In Rat Models Of Uncontrolled Hemorrhage
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Author :
language : en
Publisher:
Release Date : 2005
Efficacy Of Fda Approved Hemostatic Drugs To Improve Survival And Reduce Bleeding In Rat Models Of Uncontrolled Hemorrhage written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Several FDA-approved intravenous drugs are used to reduce surgical bleeding. This series of studies tested whether these drugs (aprotinin, desmopressin, tranexamic acid, e-aminocaproic acid) could reduce bleeding due to traumatic injuries in two models of uncontrolled hemorrhage in rats. In the first phase of each study, a lethal liver injury was produced by excising a section of the median lobe (approximately 0.8% of body weight) and an infusion of either vehicle or the test substance was immediately begun. This model included aggressive fluid resuscitation and a severe dilutional coagulopathy. Blood loss, survival time and mortality rate were measured. Three studies were performed, testing each of the drugs singly and in combination. None of the drugs significantly reduced either bleeding time or blood loss in the tail bleeding model, nor were blood loss, survival time or mortality rate altered in the liver injury model. Taken together, these results suggest that these FDA-approved drugs, when used either singly or in combination. are not efficacious in these models of traumatic uncontrolled hemorrhage.
Hemostatic Agents
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Author : Walter Henry Seegers
language : en
Publisher:
Release Date : 1948
Hemostatic Agents written by Walter Henry Seegers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1948 with Farmacologia categories.
Drugs In Relation To Blood Coagulation Haemostasis Haemostasis And Thrombosis
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Author :
language : en
Publisher:
Release Date : 1968
Drugs In Relation To Blood Coagulation Haemostasis Haemostasis And Thrombosis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with categories.
Management Of Bleeding Patients
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Author : Jun Teruya
language : en
Publisher: Springer Nature
Release Date : 2021-01-05
Management Of Bleeding Patients written by Jun Teruya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-05 with Medical categories.
This latest edition provides a comprehensive, state-of-the-art overview of the major issues specific to managing bleeding patients. Like the previous edition, the sections of this new edition have been structured to review the overall scope of issues, among them bleeding associated with disease condition, bleeding from specific organs, bleeding associated with medication, and bleeding associated with procedures. In addition to thoroughly revised and updated chapters from the previous edition, the latest edition features new chapters on such topics as the basics of hemostasis, bleeding due to rare coagulation factor deficiencies, bleeding associated with connective tissue disorders, massive transfusion protocol, bleeding associated with ventricular assist device, and evaluation of bleeding risk prior to invasive procedures. The volume also includes brief etiology and a practical reference guide regarding type of blood components, medication, dose, and duration. Written by authors from a variety of integrated disciplines, Management of Bleeding Patients, Second Edition is a valuable resource for clinicians working in the area of bleeding management.
Antifibrinolytic Drugs
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Author : Derek Ogston
language : en
Publisher: John Wiley & Sons
Release Date : 1984
Antifibrinolytic Drugs written by Derek Ogston and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medical categories.