Handbook Of Anticancer Drug Discovery And Development
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Handbook Of Anticancer Drug Discovery And Development
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Author : Octavia Settle
language : en
Publisher: American Medical Publishers
Release Date : 2023-09-26
Handbook Of Anticancer Drug Discovery And Development written by Octavia Settle and has been published by American Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Anticancer drugs refer to drugs that are used for treating cancerous or malignant diseases. They are classified into several categories, including antimetabolites, hormones, alkylating agents and natural products. Preclinical research, clinical research and post-clinical research are the three primary steps in the development of a novel drug. Clinical trial evaluation, in vivo confirmation, and in vitro cytotoxicity on cancer cells are the major assessment methods used while creating an anticancer drug. The evaluation of cytotoxicity towards cancer cell lines is a popular method for discovering anticancer agents. New cancer drugs can be discovered in a variety of ways including testing of animals, plants and fungi, understanding the chemical structure of a drug target, unintentional discovery, developing drugs that are similar to existing drugs, and researching the biology of cancer cells. This book unravels the recent studies on anticancer drug discovery and development. Those in search of information to further their knowledge will be greatly assisted by it.
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics
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Author : Michelle A. Rudek
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-01-10
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics written by Michelle A. Rudek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-10 with Medical categories.
There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Anticancer Drug Development Guide
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Anticancer Drug Development Guide written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval. They focus on using preclinical in vivo and in vitro methods to identify molecules of interest, detailing the targets and criteria for success in each type of testing and defining the value of the information obtained from the various tests. They also define each stage of clinical testing, explain the criteria for success, and outline the requirements for FDA approval. A companion volume by the same editor (Cancer Therapeutics: Experimental and Clinical Agents) reviews existing anticancer drugs and potential anticancer therapies. These two volumes in the Cancer Drug Discovery and Development series reveal how and why molecules become anticancer drugs and thus offer a blueprint for the present and the future of the field.
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics
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Author : William D. Figg
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-03-26
Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics written by William D. Figg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-26 with Medical categories.
Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Cancer Therapeutics
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-12-03
Cancer Therapeutics written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-03 with Medical categories.
Cancer drug discovery has been and continues to be a process of ingenuity, serendip ity, and dogged determination. In an effort to develop and discover better therapies against cancer, investigators all over the world have increased our knowledge of cell biology, biochemistry, and molecular biology. The goal has been to define therapeuti cally exploitable differences between normal and malignant cells. The result has been an increased understanding of cellular and whole-organism biology and an increased respect for the flexibility and resiliency ofbiologically systems. Thus, as some new therapeutic targets have been defined and new therapeutic strategies have been attempted, so have some new biological hurdles resulting from tumor evasion of the intended therapeutic attack been discovered. Historically, anticancer drugs have originated from all available chemical sources. Synthetic molecules from the chemical industry, especially dyestuffs and warfare agents, and natural products from plants, microbes, and fungi have all been potential sources of pharmaceuticals, including anticancer agents. There is no shortage of molecules; the challenge has been and continues to be methods of identifying molecules that have the potential to be therapeutically important in human malignant disease. "Screening" remains the most important and most controversial method in cancer drug discovery. In vitro screens have generally focused on cytotoxicity and have identified several highly cytotoxic molecules. Other endpoints available in vitro are inhibition of proliferation, 3 inhibition of [ H]thymidine incorporation into DNA and various viability assays, based most frequently on dye exclusion or metabolism.
Principles Of Anticancer Drug Development
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Author : Manuel Hidalgo
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-29
Principles Of Anticancer Drug Development written by Manuel Hidalgo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-29 with Medical categories.
A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
Handbook Of Cancer Vaccines
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Author : Michael A. Morse
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-01-28
Handbook Of Cancer Vaccines written by Michael A. Morse and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-01-28 with Medical categories.
An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Investigator S Handbook
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Author : National Cancer Institute (U.S.). Cancer Therapy Evaluation Program
language : en
Publisher:
Release Date : 1987
Investigator S Handbook written by National Cancer Institute (U.S.). Cancer Therapy Evaluation Program and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Drugs categories.
Anticancer Drug Development Guide
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Author : Beverly A. Teicher
language : en
Publisher: Humana
Release Date : 2004-02-01
Anticancer Drug Development Guide written by Beverly A. Teicher and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-01 with Medical categories.
This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Drug Discovery And Clinical Research
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Author : SK Gupta
language : en
Publisher: JP Medical Ltd
Release Date : 2011-06
Drug Discovery And Clinical Research written by SK Gupta and has been published by JP Medical Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06 with Medical categories.
The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update themselves and keep tabs on the latest developments in the industry. To meet these challenges, this book entitled Drug Discovery and Clinical Research has been compiled. All chapters have been written by stalwarts of the field who have their finger on the pulse of the industry. The aim of the book is to provide succinctly within one cover, an update on all aspects of this wide area. Although each of the chapter dealt here starting from drug discovery and development, clinical development, bioethics, medical devices, pharmacovigilance, data management, safety monitoring, patient recruitment, etc. are topics for full-fledged book in themselves, an effort has been made via this book to provide a bird’s eye view to readers and help them to keep abreast with the latest development despite constraints of time. It is hoped that the book will contribute to the growth of readers, which should translate into drug discovery and clinical research industry’s growth.