Heat Shock Proteins And Cytoprotection

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Heat Shock Proteins And Cytoprotection

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Author : Alexander E. Kabakov
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Heat Shock Proteins And Cytoprotection written by Alexander E. Kabakov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

Heat Shock Proteins In Myocardial Protection

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Author : Rakesh C. Kukreja
language : en
Publisher: CRC Press
Release Date : 2000-08-01

Heat Shock Proteins In Myocardial Protection written by Rakesh C. Kukreja and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-01 with Science categories.

Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.

Deciphering A Potential Cytoprotective Role Of Novel Heat Shock Responsive Proteins Using A Proteomic Approach

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Author : Charlene Patricia Kimar
language : en
Publisher:
Release Date : 2012

Deciphering A Potential Cytoprotective Role Of Novel Heat Shock Responsive Proteins Using A Proteomic Approach written by Charlene Patricia Kimar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Heart cells categories.

period of 24 hours and cell viability was assessed by the MTT assay. Two dimensional proteomic analysis was carried out to compare the proteomes of H9c2 and H9c2 cells that over-express RhoE. This research demonstrates that both RhoE and TIP4I are induced in response to heat stress and that the over-expression of RhoE is able to protect H9c2 against camptothecin induced cell death. Furthermore a proteomic 2D analysis demonstrates differential protein expression between H9c2 cells and H9c2 that over-express RhoE. Proteomic analysis demonstrates that the over-expression of RhoE leads to the down-regulation of Rho-GDI a. It can be concluded from this study that the expression of RhoE in response to heat shock is a cytoprotcctive event. The mechanism of cytoprotection is likely to involve Rho-GDI a.

Contribution Of Heat Shock Protein 27 And Retinol Binding Protein To 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection

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Author : Jean Lanette Lord-Garcia
language : en
Publisher:
Release Date : 2008

Contribution Of Heat Shock Protein 27 And Retinol Binding Protein To 11 Deoxy 16 16 Dimethyl Prostaglandin E2 Mediated Cytoprotection written by Jean Lanette Lord-Garcia and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

11-Deoxy-16,16-dimethyl prostaglandin E2 (DDM-PGE2) protects renal proximal tubular epithelial cells (LLC-PK1) against oncotic cell death induced by 2,3,5-tris(glutathione-S-yl)hydroquinone (TGHQ). Cytoprotection is associated with the up-regulation of several proteins including actin, heat shock protein 27 (Hsp27) and retinol binding protein (RBP). This dissertation reveals the induction and phosphorylation of Hsp27 by TGHQ treatment and DDM-PGE2 pretreatment. Treatment with TGHQ results in a dose-dependent disruption of the actin cytoskeleton that correlates with a decrease in cell viability, increased generation of reactive oxygen species, and the induction of Hsp27 nuclear translocation and co-localization with actin. Moreover, DDM-PGE2 pretreatment, but not co-treatment, prevents both TGHQ generation of ROS and actin cytoskeletal damage. DDM-PGE2 results in the enhanced induction and phosphorylation of nuclear Hsp27 that likely contributes to the inhibition of early effects of TGHQ induced ROS generation on the actin cytoskeleton. In correlation, we identify site specific phosphorylation of Hsp27 (p-Hsp27) at human Ser82 that negatively regulates cell survival, and p-Hsp27 at Ser15 associated with cell survival. We provide evidence that the TP receptor dependent increase in RBP expression is based on the ability of DDM-PGE2 to recruit the retinoid signalingpathway through activation of the RAR/RXR nuclear receptor heterodimers. All-trans retinoic acid (AtRA) pretreatment recapitulates the protective effects of DDM-PGE2 through a mechanism independent of TP receptor activation and the cytoprotective effects of AtRA were also investigated using an in vivo model. Finally, the ability of DDM-PGE2 to increase the cells antioxidant response, important in its cytoprotection against ROS is described. Taken together, these studies contribute to the mechanism of protection and will give insight into the affects of novel therapeutics in the modulation of chemical induced nephrotoxicity.

The Big Book On Small Heat Shock Proteins

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Author : Robert M. Tanguay
language : en
Publisher: Springer
Release Date : 2015-06-15

The Big Book On Small Heat Shock Proteins written by Robert M. Tanguay and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-15 with Medical categories.

Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.

Heat Shock Proteins And Stress

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Author : Alexzander A. A. Asea
language : en
Publisher: Springer
Release Date : 2018-10-24

Heat Shock Proteins And Stress written by Alexzander A. A. Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Science categories.

The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.

Heat Shock Proteins And Whole Body Physiology

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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-10

Heat Shock Proteins And Whole Body Physiology written by Alexzander A. A. Asea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-10 with Medical categories.

Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.

Heat Shock Proteins And Plants

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Author : Alexzander A. A. Asea
language : en
Publisher: Springer
Release Date : 2016-11-23

Heat Shock Proteins And Plants written by Alexzander A. A. Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-23 with Science categories.

Heat Shock Proteins and Plants provides the most up-to-date and concise reviews and progress on the role of heat shock proteins in plant biology, structure and function and is subdivided into chapters focused on Small Plant HSPs (Part I), Larger Plant HSPs (Part II) and HSPs for Therapeutic Gain (Part III). This book is written by eminent leaders and experts from around the world and is an important reference book and a must-read for undergraduate, postgraduate students and researchers in the fields of Agriculture, Botany, Crop Research, Plant Genetics and Biochemistry, Biotechnology, Drug Development and Pharmaceutical Sciences.

Heat Shock Proteins Potent Mediators Of Inflammation And Immunity

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Author : Alexzander A.A. Asea
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-05

Heat Shock Proteins Potent Mediators Of Inflammation And Immunity written by Alexzander A.A. Asea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-05 with Medical categories.

This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Regulation Of Heat Shock Protein Responses

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Author : Alexzander A A Asea
language : en
Publisher: Springer
Release Date : 2018-05-01

Regulation Of Heat Shock Protein Responses written by Alexzander A A Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-01 with Medical categories.

This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.