Hedgehog Signaling
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Hedgehog Signaling Activation In Human Cancer And Its Clinical Implications
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Author : Jingwu Xie
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-30
Hedgehog Signaling Activation In Human Cancer And Its Clinical Implications written by Jingwu Xie and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-30 with Medical categories.
Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics. The hedgehog pathway is a major pathway regulating cell differentiation, tissue polarity, stem cell maintenance and cell proliferation. It is known by now that activation of this pathway occurs in a variety of human cancer, including basal cell carcinomas (BCCs), medulloblastomas, leukemia, gastrointestinal, lung, ovarian, breast and prostate cancers. This book provides insightful views suitable for graduate students, medical students, undergraduate students, basic and clinical scientists, cancer patients as well as the general public.
Hedgehog Signaling
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-03-02
Hedgehog Signaling written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-02 with Science categories.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hedgehog signaling. Contributions from leading authorities Informs and updates on all the latest developments in the field
Hedgehog Signaling Protocols
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Author : Jamila I. Horabin
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-13
Hedgehog Signaling Protocols written by Jamila I. Horabin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-13 with Medical categories.
In both vertebrates and invertebrates, Hedgehog signaling regulates the development of the tissues and structures of the body. In addition, many cancers and diseases arise as a result of misregulation of the pathway, which makes it an incredibly important system to understand. This volume examines various methods used in the analysis of the Hedgehog signaling pathway, bringing together different lines of analyses into one accessible and comprehensive text. This volume provides a single source for investigators, presenting several different experimental approaches, which are all varied and broad in nature, as well as procedures for a variety of different model systems. Researchers will find this volume to be an invaluble tool as they work towards deeper understanding of the underlying molecular events that the Hedgehog signaling pathway regulates.
Hedgehog Signaling
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Author : Xiaochun Li
language : en
Publisher: Humana
Release Date : 2022-10-11
Hedgehog Signaling written by Xiaochun Li and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-11 with Science categories.
This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular mechanisms underlying the generation and transduction of the hedgehog (HH) signal, indicating the important role of sterols in this pathway. Within its pages, the volume examines techniques involving several key protein components in this pathway, including HH, the signaling ligand; Dispatched, a HH secretion regulator; Patched, the receptor of HH; Smoothened, the signal transducer used to transduce the HH signal across the plasma membrane; and GLI, the transcription factor to turn on HH target genes. Written in the highly successful Methods in Molecular Biology series format, chapters feature introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Hedgehog Signaling: Methods and Protocols provides researchers in clinical and basic science with a fresh and reliable reference for analyzing HH signal transduction through cell biological, biochemical, and biophysical approaches.
Smoothened Regulation In The Hedgehog Signaling Pathway
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Author : Daniel Nedelcu
language : en
Publisher:
Release Date : 2013
Smoothened Regulation In The Hedgehog Signaling Pathway written by Daniel Nedelcu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Hedgehog signaling is a pathway essential in embryonic development, adult stem cell maintenance, and is implicated in the formation and progression of cancer. Signaling in this pathway is triggered when the secreted protein Hedgehog binds to its membrane receptor, Patched. Patched normally inhibits the seven-spanner transmembrane protein Smoothened (Smo). Binding of Hedgehog inhibits Patched resulting in Smo derepression. Active Smo then triggers the activation of the cytoplasmic steps of the signaling pathway.
Hedgehog Gli Signaling In Human Disease
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Author : Ariel Ruiz i Altaba
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-06-24
Hedgehog Gli Signaling In Human Disease written by Ariel Ruiz i Altaba and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-24 with Medical categories.
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Hedgehog Signaling
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Author : P. Ingham
language : en
Publisher: Wiley-Blackwell
Release Date : 2015-12-21
Hedgehog Signaling written by P. Ingham and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-21 with Science categories.
Hedgehog Signaling: From Origins to Therapies is an in-depth survey of current understanding of Hedgehog signaling biology. Divided into three parts, the book covers mechanisms of action and evolution of the HH pathway; the biological functions of Hh, (principally in vertebrates); and clinical consequences of Hh dysfunction and the modulation of Hh signaling in regenerative medicine and cancer therapy. Accessible to a wide readership, from advanced students to clinical practicioners, Hedgehog Signaling provides comprehensive coverage of how Hedeghog proteins are processed and secreted, how they are received and interpreted by cells, and the various ways in which they control the proliferation and differentiation of a diverse range of cell types. Designed as a reference for both researchers and clinicians interested in the pathological consequences of Hh dysfunction, as well as its potential for therapeutic applications, Hedgehog Signaling will also be a useful resource for all those interested in cell signalling in development, health and disease.
Hedgehog Signaling In Organogenesis And Tumor Microenvironment
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Author : Tsuyoshi Shimo
language : en
Publisher: Mdpi AG
Release Date : 2020-10-02
Hedgehog Signaling In Organogenesis And Tumor Microenvironment written by Tsuyoshi Shimo and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-02 with Science categories.
The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers' drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.
The Importance Of The Hedgehog Signaling Pathway At The Level Of The Blood Brain Barrier
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Author :
language : en
Publisher:
Release Date : 2001
The Importance Of The Hedgehog Signaling Pathway At The Level Of The Blood Brain Barrier written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
The Presence Of The Hedgehog Signaling Pathway In Mouse Ovarian Surface Epithelial Cells
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Author : Jack Muth
language : en
Publisher:
Release Date : 2005
The Presence Of The Hedgehog Signaling Pathway In Mouse Ovarian Surface Epithelial Cells written by Jack Muth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.