Hepatitis C Virus Host Interactions And Therapeutics Current Insights And Future Perspectives
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Hepatitis C Virus Host Interactions And Therapeutics Current Insights And Future Perspectives
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Author : Imran Shahid
language : en
Publisher: Bentham Science Publishers
Release Date : 2023-01-24
Hepatitis C Virus Host Interactions And Therapeutics Current Insights And Future Perspectives written by Imran Shahid and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-24 with Medical categories.
The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease’s progression along with extrahepatic manifestations and virus invasion strategies impacting the host’s immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management. Topics covered in the chapters include 1) HCV-host interactions leading to asymptomatic acute infection, 2) the progression of acute HCV infection to chronic disease and subsequent extrahepatic comorbidities, 3) Innate and adaptive immune responses in HCV infections, 4) Consensus-based Approaches for Hepatitis C Screening and Diagnosis, 5) advances in hepatitis C therapy and global management of HCV, and 6) the outcomes of Oral Interferon-free Direct-acting Antivirals as Combination Therapies to Cure Hepatitis C. This book is a valuable addition to undergraduate and postgraduate hepatology students and physicians, clinicians, hepatologists, and health care officials involved in HCV clinical diagnosis and therapeutics.
Nanotechnology For Infectious Diseases
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Author : Saif Hameed
language : en
Publisher: Springer Nature
Release Date : 2022-04-13
Nanotechnology For Infectious Diseases written by Saif Hameed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-13 with Medical categories.
This book aims to cover the applications of nanotechnology against human infectious diseases. The chapters of the book discuss the role of nanotechnology in the efficient diagnosis and treatment of these diseases. It explicitly provides an overview of nanodiagnostics for infectious diseases from nanoparticles-based, nanodevice-based, and point-of-care platforms. The book also covers the state-of-the-art review of recent progress in biomimetic and bioengineered nanotherapies to treat infectious diseases. It also presents a nano carrier-based CRISPR/Cas9 delivery system for gene editing and its applications for developing interventional approaches against communicable diseases. Further, it reviews the recent developments in nanotechnology to engineer nanoparticles with desired physicochemical properties as a line of defense against multi-drug resistance micro-organisms. Cutting across the disciplines, this book serves as a guide for researchers in biotechnology, parasitology, and nanotechnology.
Developments In Bovine Immunology An Integrated View
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Author : Kieran G. Meade
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-22
Developments In Bovine Immunology An Integrated View written by Kieran G. Meade and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-22 with Bovine studies categories.
The world’s population is predicted to hit 9 Billion by 2050, and with it food demand is predicted to increase substantially. The World Bank estimates that cereal and meat production needs to increase by 50% and 85% respectively between 2000 and 2030 to meet demand, putting serious pressure on the global agricultural industry. Critical to meeting this demand for food are mechanisms to reduce the incidence of animal disease. With in excess of 1.3 billion cattle globally, the total cost of infectious diseases is difficult to estimate. However in North America alone, the cost is predicted to be $18 billion annually. Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming. However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health. Controlling diseases, through better preventative and treatment methods requires a detailed understanding of the immune response in livestock species. Multiple studies have identified associations between variation in immune genes and disease susceptibility, which potentially opens up new avenues to select animals with superior disease resistance. Detailed understanding of immunity in cattle is leading to the design of more effective vaccines. Furthermore, appreciation of the significant differences between rodent and human immune responses has also led to bovine models being developed for some human diseases. The publication of the bovine genome and the advent of next-generation sequencing technologies have facilitated a massive expansion in our knowledge of the immune response in cattle. As a result there has been an explosion of exciting research findings including in metagenomics and epigenetics. Recently, there has been a welcome move to integrate our emerging understanding of the immune response with detailed studies of other important physiological processes including nutrition and reproduction. The interactions between the reproductive system, nutrition and the immune system are of particular interest, since each places significant demands on the animal at various stages through the production cycle. The interplay between these morphologically diffuse systems involves widely distributed chemical signals in response to environmental input, and each system must interact for the normal functioning of the other. A comprehensive “systems” approach is improving our understanding of normal physiological interactions between these systems and furthermore, how dysregulation can lead to disease. The successful translation of bovine immunological research into improved treatments for animal disease requires tight interaction between diverse scientific and clinical disciplines including immunology, microbiology, endocrinology, physiology, nutrition, reproduction and clinical veterinary medicine. With so much recent progress in the field, we believe that it is valuable and well-timed to review the broad variety of the relevant studies that attempt to increase our understanding through comprehensive collaboration between these disciplines. We are looking forward to a wide and vivid discussion of developments in bovine immunology and related issues, and we expect that our readers profoundly benefit from new exciting insights and fruitful collaborations.
Advanced Concepts In Human Immunology Prospects For Disease Control
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Author : Pooja Jain
language : en
Publisher: Springer Nature
Release Date : 2020-08-11
Advanced Concepts In Human Immunology Prospects For Disease Control written by Pooja Jain and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-11 with Medical categories.
This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1991
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medicine categories.
Encyclopedia Of Virology
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-02-24
Encyclopedia Of Virology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-24 with Science categories.
Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard
Hepatitis C Virus From Molecular Virology To Antiviral Therapy
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Author : Ralf Bartenschlager
language : en
Publisher: Springer
Release Date : 2013-03-27
Hepatitis C Virus From Molecular Virology To Antiviral Therapy written by Ralf Bartenschlager and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-27 with Medical categories.
Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
Insights Into Direct Acting Antivirals
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Author : Mohamed Mahmoud Zakaria El-Kassas
language : en
Publisher: Academic Press
Release Date : 2026-02-01
Insights Into Direct Acting Antivirals written by Mohamed Mahmoud Zakaria El-Kassas and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2026-02-01 with Science categories.
Insights Into Direct-Acting Antivirals: Mechanistic Impact on Chronic Hepatitis C is a comprehensive reference that explores Chronic Hepatitis C management. This authoritative reference covers the mechanisms, efficacy, and future potential of Direct-Acting Antivirals (DAAs), offering valuable insights for clinicians, researchers, and students in hepatology and infectious diseases. Structured into three sections, this reference covers a wide range of topics related to DAAs in the management of Hepatitis C. In Section 1, readers will gain a thorough understanding of HCV infection, its clinical significance, and the immune response involved. They will also explore the molecular mechanisms of DAAs and the different classes available. Section 2 focuses on the practical aspects of using DAAs in the treatment of HCV. Readers will discover the clinical efficacy of different DAA regimens, the safety and tolerability considerations, and the additional benefits of DAA treatment beyond virological response. The section also covers current treatment guidelines and individualized approaches for specific patient populations. In Section 3, readers will learn the challenges and future directions in DAA therapy including antiviral resistance in HCV and strategies for managing and overcoming resistance. The book also explores the relationship between DAA therapy and hepatocellular carcinoma, as well as the current limitations and unmet needs in DAA therapy. "Insights Into Direct-Acting Antivirals: Mechanistic Impact on Chronic Hepatitis C" is a comprehensive and indispensable resource for anyone involved in the management of Chronic Hepatitis C. With its in-depth exploration of DAAs, from their molecular mechanisms to their clinical applications and future directions, this book equips clinicians, researchers, and students with the knowledge and insights needed to enhance their practices and contribute to the global fight against HCV infection.
Platforms For Exploring Host Pathogen Interactions In Hepatitis C Virus Infection
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Author : Kartik Trehan
language : en
Publisher:
Release Date : 2012
Platforms For Exploring Host Pathogen Interactions In Hepatitis C Virus Infection written by Kartik Trehan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Afflicting almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available experimental tools. Due to the cost and unreliability of existing humanized mouse and primate in vivo models, HCV research is almost exclusively performed using in vitro platforms which suffer from three major limitations. First, challenges in primary hepatocyte culture and the general non-permissiveness of liver cell lines have necessitated the use of a uniquely permissive hepatoma line derived from a single donor, questioning the generalizability of findings to the broader population. Second, this cell line deviates appreciably from native liver in functions central to HCV infection, including innate immune signaling, polarization, and proliferation. Third, infection is typically studied using bulk assays with suboptimal specificity, sensitivity, and content. Here, we describe three technologies for overcoming these limitations in the study of host-virus interactions. We demonstrate their utility in exploring innate immune signaling, a clinically significant component of HCV pathogenesis. Section I describes an in vitro platform for investigating inter-host variations in the natural history of infection and treatment response. We show that directed differentiation of induced pluripotent stem cells (iPSCs) yields patient-specific liver tissue that is permissive to HCV and responds to infection with a robust innate immune response, opening the door to "personalizing" the study and treatment of infection. In Section II, we demonstrate that tissue-engineered, micropatterned co-cultures (MPCCs) of primary hepatocytes and supportive stroma are permissive to HCV, enabling investigations in a more natural host. We then show that innate immune signaling curtails infection in this model, and that its inhibition enhances infection 2-3 orders of magnitude. Lastly, we use MPCCs to uncover a novel liver immunoregulatory mechanism whereby innate immune surveillance is depressed, permitting efficient replication of hepatotropic pathogens. Finally, Section III details a high-content imaging assay that enables visualization and enumeration of single viral genomes in individual cells. We demonstrate that single-cell, multiplexed quantification of viral genomes and host gene transcripts can be used to dissect host-virus interactions, yielding an unexpected positive correlation between stage of infection and response to an innate immune cytokine. The solutions described here will enable the pursuit of previously intractable research questions for HCV and other viruses, accelerating progress towards the development of antivirals and vaccines. Further, the insights gained regarding the interplay between HCV and innate immunity have important clinical ramifications, including a novel therapeutic strategy.
Hepatitis C Virus Ii
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Author : Tatsuo Miyamura
language : en
Publisher: Springer
Release Date : 2016-10-28
Hepatitis C Virus Ii written by Tatsuo Miyamura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-28 with Medical categories.
This book helps scientists, clinicians and other interested individuals understand recent clinical advances and challenges for the future. It covers many basic aspects of the pathogenesis of chronic hepatitis C, HCV infections in particular populations, approaches to therapy, and prevention and control of HCV Infection. The book provides a succinct review of the large amount of data generated by multiple groups over the past two decades that has revealed the natural history of HCV infection. Similarly, it summarizes current understanding of the origins of HCV-associated hepatocellular carcinoma, cirrhosis and hepatic fibrosis. Extra-hepatic manifestation and metabolic disorders related to HCV infection are described. In this volume, these clinically important aspects of HCV infection are comprehensively described. Highlights are description of newly developed direct- acting antivirals. The authors represent a worldwide distribution of leaders in the field reflecting the global nature of HCV infection. Based on recent data concerning the genetic- and geographical diversity of HCV, and increased global disease burden of HCV infection, challenges for global control of HCV infections are described.