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Hepatitis Prevention And Treatment

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Hepatitis Prevention And Treatment

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Author : Joseph M. Colacino
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06

Hepatitis Prevention And Treatment written by Joseph M. Colacino and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide. Because of their unique modes of replication and intimate association with the host immune system, hepatitis B virus (HBV) and hepatitis C virus (HCV) pose challenging problems to scientists in basic and applied research as well as to clinicians engaged in disease management. Although approved antiviral therapy is available for chronic HBV, the emergence of viral resistance provides a rationale for the development of novel chemotherapeutic agents. The lack of a robust cell culture system for HCV replication and a readily accessible small-animal model of HCV infection have hampered the development of antiviral agents for HCV. Neverthe-less, new antiviral agents targeting HCV are now in preclinical and clinical development. This monograph, providing an up-to-date overview of the field of Hepatitis Prevention and Treatment, includes contributions from internationally recognized experts in the field of viral hepatitis, and covers the current state of knowledge and practice regarding the molecular biology, immunology, biochemistry, pharmacology and clinical aspects of chronic HBV and HCV infection. The volume includes salient topics such as: the history and epidemiology of HBV and HCV; recent insights into the molecular mechanisms of viral replication; the host immune response to infection and a discussion of the use (HBV) or potential development (HCV) of vaccines; the current standard of care for chronically-infected patients; and emerging therapies and issues associated with current antiviral treatments. The latest information to researchers and clinicians actively engaged in viral hepatitis research is provided, but also sufficient background and discussion of the literature to benefit the newcomer to the field.

Viral Hepatitis In Children

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Author : Mei-Hwei Chang
language : en
Publisher: Springer
Release Date : 2019-07-15

Viral Hepatitis In Children written by Mei-Hwei Chang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-15 with Medical categories.

This book is aimed to emphasize the rationale and importance of prevention and management of viral hepatitis in children, providing cutting edge knowledge. Viral hepatitis is a major health problem in the world. Although most complications of viral hepatitis are observed in adults, primary infection with hepatitis viruses often occurs during infancy or childhood. To better control viral hepatitis, prevention and therapy if possible should be started in childhood. This book offers updated and unique information about viral hepatitis in children, which has vitally important impact on global disease outcome and control, yet not discussed as frequently as viral hepatitis in adults in previous medical literature. Better prevention and management strategies are covered, starting from infancy and childhood, and even earlier during fetal life. It will be very helpful for better control of viral hepatitis both for daily practice and for developing future strategies and directions. If we can successfully control viral hepatitis in children, there will be very little remaining chronic hepatitis and related complications such as liver cirrhosis or hepatoma in adults. We hope readers, including medical students, researchers, pediatricians, family medicine physicians, infectious disease personnel, public health workers, gastroenterologists, hepatologists and parents of children with chronic hepatitis, will be benefited by reading this book.

Hepatitis Prevention And Treatment

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Author : Joseph M Colacino
language : en
Publisher:
Release Date : 2004-10-25

Hepatitis Prevention And Treatment written by Joseph M Colacino and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-25 with categories.

Hepatitis And Liver Cancer

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2010-04-23

Hepatitis And Liver Cancer written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-23 with Medical categories.

The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.

Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Virus Infection

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Author : WHO.
language : en
Publisher:
Release Date : 2015

Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Virus Infection written by WHO. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Chronic diseases categories.

Global Hepatitis B Prevention And Treatment

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Author : David William Hutton
language : en
Publisher: Stanford University
Release Date : 2010

Global Hepatitis B Prevention And Treatment written by David William Hutton and has been published by Stanford University this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Hepatitis B (HBV) is a vaccine-preventable viral disease that, if untreated, can lead to death from liver disease in 25 percent of patients. Infection with HBV is a major global public health problem, particularly in Asian populations. In an era of limited healthcare budgets, mathematical models can be useful tools to identify cost-effective programs and to support policymakers in making informed decisions. This dissertation describes research on public health policies related to screening, vaccination, and treatment for HBV. It also describe contributions to the theoretical literature on when to stop catch-up vaccination for chronic infectious diseases. In the United States as many as 10% of Asian and Pacific Islander adults are chronically infected with HBV, and up to two thirds are unaware that they are infected. Using Markov models of infection, treatment and disease, I find that screening programs for HBV among Asian and Pacific Islander adults are likely to be cost effective and have clinically significant benefits from identifying chronically infected persons for medical management. Liver disease associated with childhood-acquired HBV is a leading cause of death among adults in China. Approximately 20% of children under age 5 years and 40% of children aged 5 to 19 years remain unprotected from HBV. Using a Markov model of infection and disease progression I find that HBV catch-up vaccination for children and adolescents in China would improve the health of the population and save costs over the long term. Although the 20th century has seen incredible development of safe and effective vaccines, many people remain susceptible to vaccine-preventable diseases. "Catch-up vaccination" for age groups beyond infancy can be an attractive and effective means of immunizing people who were missed earlier. However, as vaccination rates increase, catch-up vaccination may become less attractive. This chapter addresses the question of when to discontinue catch-up vaccination programs as immunization rates increase. I use a cost-effectiveness framework: I consider the cost per quality-adjusted life year gained of catch-up vaccination efforts, as a function of immunization rates over time and consequent disease prevalence and incidence. I illustrate the results with the example of HBV catch-up vaccination in China. I contrast results from a dynamic modeling approach with an approach that ignores the impact of vaccination on disease incidence.

Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Infection

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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2015-08-05

Guidelines For The Prevention Care And Treatment Of Persons With Chronic Hepatitis B Infection written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-05 with Medical categories.

These are the first World Health Organization (WHO) guidelines for the prevention care and treatment of persons living with CHB infection and complement similar recent published guidance by WHO on the prevention care and treatment of infection due to the hepatitis C virus (HCV). In contrast to several recent international guidelines on the management of CHB infection from the United States Europe Asia-Pacific and the United Kingdom (UK) the primary audience for these WHO guidelines is country programme managers in all settings but particularly in LMICs to help plan the development and scale up of hepatitis B prevention care and treatment. These guidelines are also intended for health-care providers who care for persons with CHB in these settings. The recommendations are structured along the continuum of care for persons with CHBa from initial assessment of stage of disease and eligibility for treatment to initiation of first-line antiviral therapy and monitoring for disease progression toxicity and HCC and switch to second-line drugs in persons with treatment failure. They are intended for use across age groups and adult populations. The recommendations in these guidelines promote the use of simple non-invasive diagnostic tests to assess the stage of liver disease and eligibility for treatment; prioritize treatment for those with most advanced liver disease and at greatest risk of mortality; and recommend the preferred use of nucleos(t)ide analogues with a high barrier to drug resistance (tenofovir and entecavir and entecavir in children aged 2–11 years) for first- and second-line treatment. These guidelines also recommend lifelong treatment in those with cirrhosis; and regular monitoring for disease progression toxicity of drugs and early detection of HCC. An additional chapter highlights management considerations for specific populations including those coinfected with HIV HCV and hepatitis D virus (HDV); children and adolescents; and pregnant women.

Prevention And Control Of Hepatitis B In The Community

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Author : Pia Grosheide
language : en
Publisher:
Release Date : 1996

Prevention And Control Of Hepatitis B In The Community written by Pia Grosheide and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

Viral Hepatitis

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Author : Steven Specter
language : en
Publisher: Humana
Release Date : 2010-11-05

Viral Hepatitis written by Steven Specter and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-05 with Medical categories.

Leading international virologists review the state-of-the-art in the biology, pathogenesis, and epidemiology of the hepatitis viruses. The authorities writing here examine the five well-recognized hepatitis viruses, A through E, and some of the newer agents, the so-called non- A-E hepatitis viruses. They also provide in-depth discussions of the biological nature of the viruses, the pathogenesis of the acute and chronic diseases they cause, the methods and ease with which they are transmitted, and their clinical signs and symptoms. Additional topics include diagnostic tests and routine blood screening, new vaccines, and the use of interferon and antiviral drugs. Viral Hepatitis: Diagnosis, Therapy, and Prevention provides the most comprehensive and up-to-date survey of the hepatitis viruses currently available

A National Strategy For The Elimination Of Hepatitis B And C

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-06-30

A National Strategy For The Elimination Of Hepatitis B And C written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-30 with Medical categories.

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the second of two, builds off the conclusions of the first report and outlines a strategy for hepatitis reduction over time and specific actions to achieve them.

Hepatitis Prevention And Treatment

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