High Throughput Sequencing Based Investigation Of Chronic Disease Markers And Mechanisms
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High Throughput Sequencing Based Investigation Of Chronic Disease Markers And Mechanisms
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Author : Hua Li
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-12
High Throughput Sequencing Based Investigation Of Chronic Disease Markers And Mechanisms written by Hua Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-12 with Science categories.
High Throughput Sequencing Based Investigation Of Chronic Disease Markers And Mechanisms Volume Ii
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Author : Hua Li
language : en
Publisher: Frontiers Media SA
Release Date : 2025-06-17
High Throughput Sequencing Based Investigation Of Chronic Disease Markers And Mechanisms Volume Ii written by Hua Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-17 with Science categories.
With the recent development of sequencing technology and the rapid reduction of sequencing costs, high-throughput sequencing (including second and third-generation sequencing) is revolutionizing basic life science research and clinical research from various aspects. High-throughput sequencing often produces millions of sequencing reads at a time, and the alignment or assembly of these reads allows the determination of various mutations (e.g., SNV and Indels) at the genomic level, accurate gene expression quantification at the transcriptomic level, and identification of histone or DNA modification at the epigenomic level. The resulting accumulation of enormous multi-omics information has opened up a new era of finding effective disease markers and studying their roles in disease occurrence and development. Using high-throughput sequencing, various markers of chronic diseases (such as cancer, heart disease, diabetes, and arthritis) have been developed at all omics levels, which have been used for diagnosis and classification of diseases, prediction of treatment effects, and prevention of diseases. The quickly and massively acquired multi-omics data, together with newly developed algorithms, provide an excellent chance for the identification of more reliable biomarkers. This research topic aims at (1) developing new chronic disease markers at four levels (i.e., genome, epigenome, transcriptome, and translatome) with the help of high-throughput sequencing, and (2) delineating potential marker-related mechanisms for chronic disease occurrence or development. This research topic covers a broad spectrum of interests, and studies including both wet lab and dry lab results are more welcomed. More specifically, this research topic welcomes contributions including but not limited to the following areas: 1. Identification of novel biomarkers for chronic disease detection (especially in early-stage) or prognosis prediction using high-throughput sequencing; 2. characterize the possible pathological causes of markers as well as the potential roles they play in disease initiation and development; 3. New high-throughput sequencing techniques that facilitate the development of more effective biomarkers of chronic disease; 4. New algorithms or tools for in silico identification of effective chronic disease markers based on high-throughput sequencing data. Please note that: (1) the high-throughput sequencing for genome, epigenome, transcriptome, and translatome (i.e., ribosome-associated RNA) is preferred for this topic; (2) at least some dry lab results need to be validated with wet-lab experiments; (3) studies successfully uncovering biomarker-related disease mechanisms will be highly preferred.
Bioinformatics Of Genome Regulation Volume I 2nd Edition
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Author : Yuriy L. Orlov
language : en
Publisher: Frontiers Media SA
Release Date :
Bioinformatics Of Genome Regulation Volume I 2nd Edition written by Yuriy L. Orlov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Science categories.
Publisher’s note: In this 2nd edition, the following article has been updated: Orlov YL, Tatarinova TV, Oparina NY, Galieva ER and Baranova AV (2021) Editorial: Bioinformatics of Genome Regulation, Volume I. Front. Genet. 12:803273. doi: 10.3389/fgene.2021.803273
Bioinformatics Of Genome Regulation Volume Ii
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Author : Yuriy L. Orlov
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-27
Bioinformatics Of Genome Regulation Volume Ii written by Yuriy L. Orlov and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-27 with Science categories.
Association Between Individuals Genomic Ancestry And Variation In Disease Susceptibility
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Author : Ranajit Das
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-03
Association Between Individuals Genomic Ancestry And Variation In Disease Susceptibility written by Ranajit Das and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-03 with Science categories.
Topic Editor Ranajit Das is the Founder Director of Genome Mapster and Infygene Genomic Healthcare. Topic Editor Tatiana Tatarinova holds patents related to the Research Topic subject. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Molecular Mechanisms In Chronic Kidney Disease
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Author : Claudia Torino
language : en
Publisher: Frontiers Media SA
Release Date : 2021-09-02
Molecular Mechanisms In Chronic Kidney Disease written by Claudia Torino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Science categories.
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases
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Author : Min Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases written by Min Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Genomic And Personalized Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-10-30
Genomic And Personalized Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-30 with Science categories.
Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. - Highly Commended 2013 BMA Medical Book Award for Medicine - More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition - Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics - Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine - Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Dubois Lupus Erythematosus And Related Syndromes E Book
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Author : Daniel J. Wallace
language : en
Publisher: Elsevier Health Sciences
Release Date : 2023-12-04
Dubois Lupus Erythematosus And Related Syndromes E Book written by Daniel J. Wallace and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-04 with Medical categories.
**Selected for 2025 Doody's Core Titles® in Rheumatology**For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the 10th edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Includes significant new content throughout: a new chapter on the endocrine system and hormones; newly distinct chapters on the heart and lung; new content on social disparities in lupus, clinical presentation of nephritis, and pulmonary hypertension; a new concluding chapter on future directions in the field; new basic science coverage of the microbiome, autoinflammatory, and monogenic lupus; and new coverage of diversity, inclusion, gender, compliance, and adherence. - Offers a fresh perspective from two new associate editors and many new authors with representation from 30 countries. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Discusses the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, new and improved figures, and schematic diagrams throughout. - Additional digital ancillary content may publish up to 6 weeks following the publication date.
Biomedical Index To Phs Supported Research
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Author :
language : en
Publisher:
Release Date : 1990
Biomedical Index To Phs Supported Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medicine categories.