Histamine In Inflammation
DOWNLOAD
Download Histamine In Inflammation PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Histamine In Inflammation book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Histamine In Inflammation
DOWNLOAD
Author : Robin Thurmond
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-29
Histamine In Inflammation written by Robin Thurmond and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-29 with Medical categories.
The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
Histamine And Inflammation
DOWNLOAD
Author : András Falus
language : en
Publisher: R. G. Landes
Release Date : 1994
Histamine And Inflammation written by András Falus and has been published by R. G. Landes this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Histamine categories.
Histamine is released in allergic, inflammatory reactions. This comprehensive text fully examines the physiological, biochemical and clinical significance of this mediator with a central role in allergic reaction.
Histamine And H2 Antagonists In Inflammation And Immunodeficiency
DOWNLOAD
Author : Ross Elliot Rocklin
language : en
Publisher: Marcel Dekker
Release Date : 1990
Histamine And H2 Antagonists In Inflammation And Immunodeficiency written by Ross Elliot Rocklin and has been published by Marcel Dekker this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
Inflammation
DOWNLOAD
Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-27
Inflammation written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-27 with Medical categories.
Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.
Histamine H4 Receptor
DOWNLOAD
Author : Holger Stark
language : en
Publisher: Walter de Gruyter
Release Date : 2013-11-20
Histamine H4 Receptor written by Holger Stark and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-20 with Science categories.
H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.
Chemical Mediators Of The Acute Inflammatory Reaction
DOWNLOAD
Author : M. Rocha E Silva
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Chemical Mediators Of The Acute Inflammatory Reaction written by M. Rocha E Silva and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
International Series of Monographs in Pure and Applied Biology, Modern Trends in Physiological Sciences, Volume 37: Chemical Mediators of the Acute Inflammatory Reaction traces the history of investigation into the acute inflammatory reaction from the early observations in invertebrates to the experiments of therapeutic significance for humans. This book focuses on mediators that are accepted as being commonly involved in the inflammatory reaction, such as histamine, kinins, serotonin, prostaglandins, and permeability factors. The topics discussed include the phagocytic system and antibody production; factors which influence phagocytosis; measurement of the acute inflammatory reaction; and combined actions of mediators. The reaction to injury and manifestation of inflammation and biochemical aspects of anti-inflammatory drug reaction are also covered. This volume is beneficial to anatomists, biochemists, physiologists, immunologists, pathologists, pharmacologists, and clinicians interested in acute inflammatory reaction.
Mediators Of Inflammation
DOWNLOAD
Author : Gerald Weissmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Mediators Of Inflammation written by Gerald Weissmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Medical categories.
Lewis Thomas has suggested that "Perhaps the inflammatory reaction should be regarded as a defense of an individual against all the rest of nature, symbolizing his individuality and announcing his existence as an entity. " Provision of these symbols and announcements is the task of various mediators of inflammation and this volume has been designed to present our current understanding of their biochemistry, cellular origins, pharmacology, and role in pathology. Unlike other volumes of collected papers, this book did not result from a specific conference or symposium at which each contributor presented his own, narrowly framed research experience. Rather, each of the chapters represents, in the form of a general review, a summary of our knowledge of the mediators and the mecha nisms by which they are released to launch the inflammatory response. Much effort has been taken to insure that the often conflicting terminology in this field is defmed in detail: many synonyms (e. g. , of the properdin system or the alternate pathway of complement activation) have been repeatedly presented, in order to avoid confusion. Although each of the contributors is actively engaged in the field of inflammation, few text figures or tables of ongoing research have been included; the overall aim was to provide a volume readily accessible to workers in other areas as well as to the general reader.
Immunopharmacology And Inflammation
DOWNLOAD
Author : Carlo Riccardi
language : en
Publisher: Springer
Release Date : 2018-06-09
Immunopharmacology And Inflammation written by Carlo Riccardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Medical categories.
A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
Histamine And Activation Of Histamine Receptors As Drivers Of Early Inflammation And Gut Function In Pigs
DOWNLOAD
Author : Kyan Thelen
language : en
Publisher:
Release Date : 2023
Histamine And Activation Of Histamine Receptors As Drivers Of Early Inflammation And Gut Function In Pigs written by Kyan Thelen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Electronic dissertations categories.
Early life adversity has been established as a major risk factor for the development of inflammatory disease as well as increased mortality in humans. In swine production, weaning is a necessary practice, but is also the most stressful life event that a piglet will endure. Weaning stress-induced increases in inflammation and intestinal permeability occur during the window of developmental plasticity, which has been demonstrated to cause persistent detrimental effects on the gut, including chronic inflammation and epithelial barrier permeability. Despite efforts to improve growth performance and overall health, the lack of targeted interventions is a significant issue. The critical problem regarding the limited understanding of the mechanisms driving early responses to weaning stress urgently needs to be addressed. The objective of this dissertation is to investigate the role of histamine receptors as a potential mechanism and target to mitigate the inflammatory response and gut dysfunction induced by weaning stress.First, we sought to characterize the inflammatory response to weaning stress and the role of histamine receptors. As histamine has been shown to be upregulated in response to stress and histamine receptors are well known to be critical in allergic inflammation, we hypothesized that histamine receptors are responsible for early gastrointestinal (GI) inflammation. To test this, we utilized a porcine weaning model of early life stress and administration of pharmacological histamine receptor antagonists.Next, we investigated the role of histamine receptors in early changes in gut function, including epithelial barrier permeability, nutrient transport, and neural-evoked secretions. Through the employment of Using Chambers analyses, we were able to make ex vivo assessments of the aforementioned gut functions in response to weaning stress, as well as in response to selective inhibition of histamine receptors.Together, our data indicate that histamine receptor subtypes play critical, yet distinct roles in mediating early weaning stress responses in pigs. This provides evidence that histamine and histamine receptors are novel biological targets in mitigating early inflammatory and functional responses to stress in the gut. Future studies should focus on long-term effects of histamine receptors in GI development post weaning stress, as well as determining their role in secondary immune challenges.
Biomedical Aspects Of Histamine
DOWNLOAD
Author : Nancy Khardori
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-30
Biomedical Aspects Of Histamine written by Nancy Khardori and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-30 with Medical categories.
Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.