Biomedical Aspects Of Histamine
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Biomedical Aspects Of Histamine
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Author : Nancy Khardori
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-30
Biomedical Aspects Of Histamine written by Nancy Khardori and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-30 with Medical categories.
Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.
Histamine
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Author : András Falus
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2004
Histamine written by András Falus and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Histamine, discovered in 1910 by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in neurotransmission, immunomodulation, the regulation of cell proliferation, etc. This book provides a comprehensive overview of histamine biology including structure, anabolic and catabolic enzymes, receptors and their ligands. It outlines the details of histamine physiology such as its role in the immune response, nutrition and neuro/psychobiology, and covers medical fields like allergy, gastroenterology, oncology, sepsis, posttraumatic stress, embryonic development and hematopoiesis. Also considered is the structural and functional genomics of histamine. Presenting the most recent advances in histamine research from basic science to clinical medicine, this book is a valuable source for students, graduates and postgraduates in medicine and the life sciences, and to anyone interested in this multifaceted molecule.
Histamine Receptors
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Author : Patrizio Blandina
language : en
Publisher: Springer
Release Date : 2016-11-07
Histamine Receptors written by Patrizio Blandina and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
Histamine Receptors As Drug Targets
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Author : Ekaterini Tiligada
language : en
Publisher: Humana
Release Date : 2017-03-09
Histamine Receptors As Drug Targets written by Ekaterini Tiligada and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-09 with Medical categories.
This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
Histamine In The Brain
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Author : Jian-Sheng Lin
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-18
Histamine In The Brain written by Jian-Sheng Lin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-18 with Brain categories.
Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Histamine In Inflammation
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Author : Robin Thurmond
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-29
Histamine In Inflammation written by Robin Thurmond and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-29 with Medical categories.
The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
Basic Neurochemistry
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Author : R. Wayne Albers
language : en
Publisher: Academic Press
Release Date : 2011-11-02
Basic Neurochemistry written by R. Wayne Albers and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Science categories.
Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475
Biogenic Amines In Food
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Author : Bahruddin Saad
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019-11-01
Biogenic Amines In Food written by Bahruddin Saad and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-01 with Technology & Engineering categories.
A precise analysis of biogenic amines is important as an indicator of food freshness or spoilage that can cause serious toxicity. This book provides comprehensive background information on biogenic amines and their occurrence in various foods and drinks such as fermented and non-fermented sausages and fish products, cheeses, vegetables and beverages, e.g. beer, cider and wine. It gives a detailed description of both the established analytical methods and the emerging technologies for the analysis of them. As the first book on the detection of biogenic amines in all types of food, it provides help to get a better understanding of the risks associated with biogenic amines and how to avoid them. It serves as an excellent and up-to-date reference for food scientists, food chemists and food safety professionals.
Biomedical Aspects Of Iuds
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Author : H. Hasson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biomedical Aspects Of Iuds written by H. Hasson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains a collection of papers based on presentations made at the Reproductive Health Care International Symposium held in Maui, Hawaii, USA, October 1982. The papers evaluate biologic interactions be tween intrauterine contraceptive devices and the host, examine the risks associated with the use of these devices and describe aspects of technical progress in the field. The contributing authors bring their knowledge and expertise from four corners of the world to the readers. The editors wish to express their appreciation to the authors for their valuable contributions, to Carolyn K. Osborn for helpful assistance in editing the manuscripts and to MTP Press for accurate preparation and fine presentation of the material. It is hoped that this volume will serve to expand knowledge and generate further interest among its readers in the dynamic and fascinating field of intrauterine contraception. April, 1984 H.M. Hasson, MD Chicago, Illinois, USA ix 1 Ultrastructure of the decidual response to a progesterone releasing IUD U.M. SPORNITZ. K.S. LUDWIG and M. MALL-HAEFELI INTRODUCTION The ever-increasing world-wide use of the IUD has prompted intensive research into the physiology of its contraceptive action. From these studies it has become clear that the alterations in morphology as well as in the physiological milieu produced by the IUD are manifold and differ greatly with the type of IUD used.
Immunopharmacology And Inflammation
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Author : Carlo Riccardi
language : en
Publisher: Springer
Release Date : 2018-06-09
Immunopharmacology And Inflammation written by Carlo Riccardi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Medical categories.
A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.