Histamine Receptors
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Histamine Receptors
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Author : Patrizio Blandina
language : en
Publisher: Springer
Release Date : 2016-11-07
Histamine Receptors written by Patrizio Blandina and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
Histamine And Histamine Receptors In Health And Disease
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Author : Yuichi Hattori
language : en
Publisher: Springer
Release Date : 2017-05-22
Histamine And Histamine Receptors In Health And Disease written by Yuichi Hattori and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.
Pharmacology Of Histamine Receptors
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Author : C. R. Ganellin
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Pharmacology Of Histamine Receptors written by C. R. Ganellin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.
The Functional Roles Of Histamine Receptors
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Author : Kazuhiko Yanai
language : en
Publisher: Springer Nature
Release Date : 2022-09-28
The Functional Roles Of Histamine Receptors written by Kazuhiko Yanai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.
The Histamine Receptor
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Author : J. C. Schwartz
language : en
Publisher:
Release Date : 1992-01-24
The Histamine Receptor written by J. C. Schwartz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-24 with Medical categories.
Synthesizes the latest information and research involving the pharmacochemistry, biochemical properties and neurobiological function of histamine receptors. Contains over 50 illustrations.
H1 And H2 Histamine Receptors
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Author : Guy A. Settipane
language : en
Publisher:
Release Date : 1988
H1 And H2 Histamine Receptors written by Guy A. Settipane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antihistamines categories.
Biomedical Aspects Of Histamine
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Author : Nancy Khardori
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-30
Biomedical Aspects Of Histamine written by Nancy Khardori and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-30 with Medical categories.
Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.
The Third Histamine Receptor
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Author : Divya Vohora
language : en
Publisher: CRC Press
Release Date : 2008-11-14
The Third Histamine Receptor written by Divya Vohora and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-14 with Science categories.
Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and Disorders The H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer’s disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodegeneration. In light of dramatic advances in research at the molecular level, supported by impressive clinical studies, optimism remains high that an H3 receptor-related drug could hit the market soon. The Third Histamine Receptor: Selective Ligands as Potential Therapeutic Agents in CNS Disorders provides a thorough grounding in advances made over the last two decades. It brings together an elite group of 30 pioneering researchers. In writing about their own work, these scientists report on the cutting-edge investigations that are now being conducted across a variety of disciplines. This text is designed to aid researchers and inform those involved in the treatment and clinical aspects of a number of histamine-related diseases. Presents Several Disease-Specific Chapters Certainly, the most comprehensive and cutting-edge volume in the field, this text includes material drawn from groundbreaking research techniques and patent literature. Put together with great thought and passion, it is written to serve as a primary resource for anyone involved with or interested in the identification and localization of H3 receptors and the ligands being developed as therapeutic agents to treat a wide range of diseases including some that were once considered intractable.
Histamine In Inflammation
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Author : Robin Thurmond
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-29
Histamine In Inflammation written by Robin Thurmond and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-29 with Medical categories.
The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
Histamine Receptors Advances In Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Histamine Receptors Advances In Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Medical categories.
Histamine Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Histamine Receptors in a compact format. The editors have built Histamine Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Histamine Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Histamine Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.