The Functional Roles Of Histamine Receptors
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The Functional Roles Of Histamine Receptors
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Author : Kazuhiko Yanai
language : en
Publisher: Springer Nature
Release Date : 2022-09-28
The Functional Roles Of Histamine Receptors written by Kazuhiko Yanai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.
Histamine And Histamine Receptors In Health And Disease
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Author : Yuichi Hattori
language : en
Publisher: Springer
Release Date : 2017-05-22
Histamine And Histamine Receptors In Health And Disease written by Yuichi Hattori and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-22 with Medical categories.
This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.
The Third Histamine Receptor
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Author : Divya Vohora
language : en
Publisher: CRC Press
Release Date : 2008-11-14
The Third Histamine Receptor written by Divya Vohora and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-14 with Medical categories.
Reveals an Emerging Avenue of Potential Treatments for a Host of Challenging Diseases and DisordersThe H3 receptor is known to play a major role in a range of CNS disorders, including those affecting cognitive functions such as ADHD and Alzheimer's disease, as well as sleep disorders, obesity, epilepsy, schizophrenia, depression, and neurodege
Biomedical Aspects Of Histamine
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Author : Nancy Khardori
language : en
Publisher: Springer
Release Date : 2014-10-14
Biomedical Aspects Of Histamine written by Nancy Khardori and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-14 with Medical categories.
Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.
Histamine Receptors
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Author : Patrizio Blandina
language : en
Publisher: Springer
Release Date : 2016-11-07
Histamine Receptors written by Patrizio Blandina and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
The Histamine H3 Receptor
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Author : R. Leurs
language : en
Publisher: Elsevier
Release Date : 1998-12-09
The Histamine H3 Receptor written by R. Leurs and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-09 with Medical categories.
In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive. The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues. In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.
Histamine
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Author : Michael A. Beaven
language : en
Publisher:
Release Date : 1978
Histamine written by Michael A. Beaven and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
The Histamine Receptor
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Author : J. C. Schwartz
language : en
Publisher:
Release Date : 1992-01-24
The Histamine Receptor written by J. C. Schwartz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-24 with Medical categories.
Synthesizes the latest information and research involving the pharmacochemistry, biochemical properties and neurobiological function of histamine receptors. Contains over 50 illustrations.
Histaminergic Neurons
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Author : Takehiko Watanabe
language : en
Publisher: CRC Press
Release Date : 1991-02-22
Histaminergic Neurons written by Takehiko Watanabe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-22 with Science categories.
This book provides an overview on the histaminergic neuron system in the brain for neuroscience, anatomy, pharmacology, biochemistry, and medical researchers. Topics discussed include the biochemistry of enzymes; histamine receptors (H1, H2, and H3); morphology, coexistance, and development of the histaminergic neuron system; electrophysiological studies on vertebrate and invertebrate neurons; as well as the functions of the histamine neurons.
H1 And H2 Histamine Receptors
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Author : Guy A. Settipane
language : en
Publisher:
Release Date : 1988
H1 And H2 Histamine Receptors written by Guy A. Settipane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antihistamines categories.