Hormonal Control Of Breast Cancer Cell Growth
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Hormonal Control Of Breast Cancer Cell Growth
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Author :
language : en
Publisher:
Release Date : 1997
Hormonal Control Of Breast Cancer Cell Growth written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Although the cause of breast cancer has not been identified yet, there is enough clinical and experimental evidence that full term pregnancy reduces the lifetime risk of developing breast cancer, a protective effect that can be mimicked by treatment of virgin animals with the placental hormone chorionic gonadotropin (hCG). In vivo this hormone inhibits both the initiation and progression of rat mammary carcinomas, and in vitro the proliferation of human breast epithelial cells (HBEC). Work performed under this grant application has led the PL to determine that treatment of immortalized, chemically transformed and malignant HBEC with hCG activates programmed cell death genes even before an arrest of cell growth has becomes evident. It also acts as an inhibitor of cell proliferation, utilizing different pathways for either activating programmed cell death genes or inhibiting specific cell cycle dependent kinases, depending upon the degree of expression of neoplastic phenotypes. The relevance of these findings lies in the potential use of hCG as a chemopreventive and chemotherapeutic agent in breast cancer, utilizing the detection of activation of programmed cell death genes as an early end point in the action of this hormone on the target tissues.
Hormonal Control Of Cell Cycle
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Author : Shlomo Melmed
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-04
Hormonal Control Of Cell Cycle written by Shlomo Melmed and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-04 with Medical categories.
This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as well as those deriving novel therapeutic approaches for these benign and malignant disorders.
Hormonal Regulation Of Mammary Tumors
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Author : Benjamin S. Leung
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Hormonal Regulation Of Mammary Tumors written by Benjamin S. Leung and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
Estrogen Antiestrogen Action And Breast Cancer Therapy
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Author : Virgil Craig Jordan
language : en
Publisher: Univ of Wisconsin Press
Release Date : 1986
Estrogen Antiestrogen Action And Breast Cancer Therapy written by Virgil Craig Jordan and has been published by Univ of Wisconsin Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Breast categories.
This book marks one of the achievements of the "Estrogen and Antiestrogen Action: Basic and Clinical Aspects" Wisconsin Clinical Cancer Center conference in June 1984. It is not intended to be a recount of the meeting proceedings but is, rather, a historical review of the development of this field of endeavor during the past 30 years. The chapters have been written by many of the leading experts in the field who were asked to recount the development of a particular area or laboratory idea in which they had been personally involved. The book is intended to provide both scientists and clinicians with a single-volume overview of both the basic principles of hormonal control of breast cancer and the recent clinical results from cooperative groups around the world.
Endocrinology Of Breast Cancer
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Author : Andrea Manni
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-01-15
Endocrinology Of Breast Cancer written by Andrea Manni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-15 with Medical categories.
A cutting-edge review of how derangements in the hormonal and growth factor mechanisms controlling normal mammary development lead to breast cancer. Drawing on the multidisciplinary expertise of leading authorities, the book highlights the roles of oncogenes and tumor suppressor genes, spelling out the importance of autocrine/paracrine loops (e.g., stromal epithelial interactions) in supporting breast cancer cell proliferation and the progression to hormone independence. The book's many prominent contributors also illuminate significant recent advances in the biochemistry and physiology of hormone receptors and review the state-of -the-art in the endocrine therapy of breast cancer. Endocrinology of Breast Cancer provides a unique integrated overview of the most significant basic and clinical developments concerning the hormonal aspects of breast cancer.
Hormones And Cancer
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Author : Wendell W. Leavitt
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Hormones And Cancer written by Wendell W. Leavitt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.
Hormonal Regulation Of Mammary Tumors
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Author : Benjamin S. Leung
language : en
Publisher: Springer London
Release Date : 1982
Hormonal Regulation Of Mammary Tumors written by Benjamin S. Leung and has been published by Springer London this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Breast categories.
Steroid Hormones And Cell Cycle Regulation
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Author : Kerry L. Burnstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Steroid Hormones And Cell Cycle Regulation written by Kerry L. Burnstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
Estrogen And Antiestrogen Regulation Of Breast Cancer Cell Growth
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Author : Shunyuan Jiang
language : en
Publisher:
Release Date : 1991
Estrogen And Antiestrogen Regulation Of Breast Cancer Cell Growth written by Shunyuan Jiang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.
Hormones And Cancer
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Author : Wayne Vedeckis
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-04-01
Hormones And Cancer written by Wayne Vedeckis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-01 with Science categories.
The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.