Host Pathogen Crosstalk Implications In Host Cellular Processes By Intracellular Pathogens
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Host Pathogen Crosstalk Implications In Host Cellular Processes By Intracellular Pathogens
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Author : Rajni Garg
language : en
Publisher: Frontiers Media SA
Release Date : 2024-11-06
Host Pathogen Crosstalk Implications In Host Cellular Processes By Intracellular Pathogens written by Rajni Garg and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Science categories.
Infectious diseases are still leading cause of mortality around the world. Of particular importance in this regard are the intracellular pathogens, which dwell inside the host and manipulate host’s machinery for their growth. These include pathogens like Brucella abortus, Listeria monocytogenes, Chlamydia trachomatis, Coxiella burnetii, Mycobacterium tuberculosis, Salmonella enterica, etc. These pathogens have evolved multiple mechanisms to survive in intracellular niche. The host in turn tries to reprogram its activities to combat their growth. This host-pathogen co-evolution warrants detailed study to probe the ever-changing virulence repertoire of the pathogen, that can be used for pathogen targeting. Through this topic, we would like to explore the lesser explored area of host pathogen interactions. Studying host-pathogen crosstalk at their interface will help us in understanding this complex biology and might prove beneficial in development of new therapeutic targets. Understanding the holistics of host-pathogen interaction, will pave way for development of host-directed therapies.
Fundamental Immunology
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Author : William E. Paul
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-12-03
Fundamental Immunology written by William E. Paul and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-03 with Medical categories.
This standard-setting textbook has defined the field of immunology since 1984, and is now in its Seventh Edition continuing to deliver the detailed, authoritative, and timely coverage readers expect. This comprehensive, up-to-date text is ideal for graduate students, post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. Now full-color throughout the book’s fully revised and updated content reflects the latest advances in the field. Current insights enhance readers’ understanding of immune system function. The text’s unique approach bridges the gap between basic immunology and the disease process. Extensive coverage of molecular biology explains the molecular dynamics underlying immune disorders and their treatment. Abundant illustrations and tables deliver essential information at a glance. Plus a convenient companion website features the fully searchable text and image bank! This is the tablet version of Fundamental Immunology which does not include access to the supplemental content mentioned in the text.
Current Trends In Exploiting Molecular Signaling In Bacteria Host Crosstalk
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Author : Monica Cartelle Gestal
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-27
Current Trends In Exploiting Molecular Signaling In Bacteria Host Crosstalk written by Monica Cartelle Gestal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-27 with Science categories.
Obligate Intracellular Bacteria Evasion And Adaptative Tactics Shaping The Host Pathogen Interface
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Author : Isaura Simões
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-09
Obligate Intracellular Bacteria Evasion And Adaptative Tactics Shaping The Host Pathogen Interface written by Isaura Simões and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-09 with Science categories.
Rising Stars In Cancer Metabolism 2022
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Author : Domenica Scumaci
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-29
Rising Stars In Cancer Metabolism 2022 written by Domenica Scumaci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Medical categories.
Handbook Of Research On Systems Biology Applications In Medicine
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Author : Daskalaki, Andriani
language : en
Publisher: IGI Global
Release Date : 2008-11-30
Handbook Of Research On Systems Biology Applications In Medicine written by Daskalaki, Andriani and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-30 with Technology & Engineering categories.
"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.
Wnt Signaling In Immune Cell Regulation During Microbial Infection And Cancer
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Author : Malini Sen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-14
Wnt Signaling In Immune Cell Regulation During Microbial Infection And Cancer written by Malini Sen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-14 with categories.
The Immunological Consequences Of Regulated Cell Death In Infection And Inflammation
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Author : Bart Tummers
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-14
The Immunological Consequences Of Regulated Cell Death In Infection And Inflammation written by Bart Tummers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-14 with Medical categories.
Bacteria Host Interactions From Infection To Carcinogenesis
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Author : Marco Antonio Hernández-Luna
language : en
Publisher: Frontiers Media SA
Release Date : 2025-07-31
Bacteria Host Interactions From Infection To Carcinogenesis written by Marco Antonio Hernández-Luna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-31 with Science categories.
Bacteria-host interactions represent a critical area of research, particularly in the context of infection and carcinogenesis. Microorganisms such as viruses and bacteria have long been implicated in the development of cancers, with notable examples including human papillomavirus (HPV) in cervical cancer and Helicobacter pylori in gastric cancer. Recent studies have expanded this understanding to include a broader range of bacteria, both pathogenic and commensal, in the carcinogenic process. This has sparked significant interest in the role of bacteria in the onset and progression of various neoplasms. While much of the research has concentrated on gastrointestinal cancers, where dysbiosis and bacterial infections are suspected contributors, emerging evidence suggests that bacteria also colonize tumor tissues in organs such as the breast, prostate, and lung. Despite these findings, the precise mechanisms by which bacteria influence tumor biology remain poorly understood, highlighting the need for further investigation. This research topic aims to describe the complex interactions between bacteria and host tissues that contribute to carcinogenesis. Specifically, it seeks to identify and characterize pathogenic bacteria associated with cancer, understand the role of bacterial toxins in carcinogenic activity, and explore the impact of dysbiosis in gastrointestinal neoplasms. Additionally, the research will investigate bacterial colonization in various tumor tissues and the resulting immunological alterations due to bacteria-tumor interactions. By addressing these questions, the research aims to fill critical gaps in our understanding and potentially uncover new avenues for cancer prevention and treatment. To gather further insights into the intricate dynamics of bacteria-host interactions in carcinogenesis, we welcome articles addressing, but not limited to, the following themes: - Pathogenic bacteria associated with carcinogenesis - Bacterial toxins with carcinogenic activity - Dysbiosis in neoplasms of the gastrointestinal tract - Bacterial colonization in tumor tissue - Immunological alterations due to bacteria-tumor tissue interaction
Metal Economy In Host Microbe Interactions
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Author : Frédéric Veyrier
language : en
Publisher: Frontiers Media SA
Release Date : 2015-06-11
Metal Economy In Host Microbe Interactions written by Frédéric Veyrier and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-11 with Infectious and parasitic diseases categories.
This Research Topic presents knowledge on transition metal metabolism in various infections from the dual perspective of offender and defender. 1) Host Nutritional Immunity: depriving or poisoning. To date, the implication of divalent metals have been described in two different immune strategies that aim to fight microbial invaders. One consists in depriving microbes of essential divalent metals whereas the other aims at overloading invaders with toxic concentrations of metal. The contributions in this section present, in different situations, various aspects of this metal economy at the host-microbe interface. Two papers deal with metal homeostasis as hosts interact with bacteria. Diaz-Ochoa et al. (2014) review immunological mechanisms to sequester Fe, Mn and Zn in the inflamed gut and strategies of commensals and pathogens to evade mucosal defenses and obtain such nutrients. Lisher & Giedroc (2013) detail chemical and structural mechanisms to capture Mn, an antioxidant used by pathogens to adapt to human hosts, and the impact of Fe and Zn on Mn bioavailability during infections. The most coveted metal, iron is key to nutritional immunity and microbial virulence. Using amoeba as model phagocyte, Bozzaro et al. (2013) present the tug of war between a bacterial predator, sequestering intracellular iron to resist invasion, and pathogens which elude such defense mechanisms. On mammalian defense against intracellular bacteria and protozoan parasites, Silva-Gomes et al. (2013) outline divergent approaches: iron-withholding to prevent microbial replication or iron-based oxidative injury to kill invaders. Host may also target invaders with toxic doses of Cu and Zn, normally kept at low concentrations. Neyrolles et al. (2013) present an opinion article on bacterial Zn and Cu poisoning in the context of Mycobacterium tuberculosis infection. Chaturvedi & Henderson (2014) summarize the specific properties of copper and its toxic effect on bacteria cells. Argüello et al. (2013) review how bacteria integrate homeostatic mechanisms to avoid Cu toxicity by sensing and regulating ion chelation, chaperoning and membrane transport. 2) Microbial adaptation to host defenses: metallo-transporters or exporters. To overcome host resistance to infection, numerous mechanisms have been selected through the course of microbial evolution, in particular transporters that can feed the bacteria even at low metal concentration or, on the contrary, metallo-exporters that can expel metals outside the cell to avoid toxic accumulation. The articles in this section describe the microbial transport arsenal, and its regulation, which play major roles to influence metal economy at the host-microbe interface. Bacterial and fungal strategies to acquire Fe is the subject of four contributions. Liu & Biville (2013) discuss erythrocyte parasitism by Bartonella, transmitted by arthropod vectors and relying principally on heme capture and oxidative stress defense to cause persistent infections. Runyen-Janecky (2013) highlights some of the recent findings on heme iron acquisition system and the regulation of their expression in Gram-negative pathogens. Cornelis & Dingemans (2013) recap how Pseudomonas adapts means of iron capture to the type of infection it establishes, acute or chronic. Caza & Kronstad (2013) contrast strategies of virulent bacteria and fungi to subvert host immunity and steal iron from hemoglobin, heme, transferrin and lactoferrin or elemental iron using specialized uptake systems and siderophores. Five papers deal with microbial homeostasis of other metals Mn, Ni and Zn. Honsa et al. (2013) review the roles of importers and exporters of Mn, Fe, Zn and Cu in Streptococcus pneumoniae gene regulation and tissue-specific pathogenesis. Guilhen et al (2013) focus on families of exporters and the role of metal efflux in the evolution of Neisseria meningitidis virulence and naso-pharyngeal c