How Does Germline Regenerate
DOWNLOAD
Download How Does Germline Regenerate PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get How Does Germline Regenerate book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
How Does Germline Regenerate
DOWNLOAD
Author : Kate MacCord
language : en
Publisher: University of Chicago Press
Release Date : 2024-01-05
How Does Germline Regenerate written by Kate MacCord and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-05 with categories.
A concise primer that complicates a convenient truth in biology--the divide between germ and somatic cells--with far-reaching ethical and public policy ramifications. Scientists have long held that we two have kinds of cells--germ and soma. Make a change to germ cells--say using genome editing--and that change will appear in the cells of future generations. Somatic cells are "safe" after such tampering; modify your skin cells, and your future children's skin cells will never know. And, while germ cells can give rise to new generations (including all of the somatic cells in a body), somatic cells can never become germ cells. How did scientists discover this relationship and distinction between somatic and germ cells--the so-called Weismann Barrier--and does it actually exist? Can somatic cells become germ cells in the way germ cells become somatic cells? That is, can germ cells regenerate from somatic cells even though conventional wisdom denies this possibility? Covering research from the late nineteenth century to the 2020s, historian and philosopher of science Kate MacCord explores how scientists came to understand and accept the dubious concept of the Weismann Barrier and what profound implications this convenient assumption has for research and policy, from genome editing to stem cell research, and much more.
Germline Maintenance And Regeneration In The Amphipod Crustacean Parhyale Hawaiensis
DOWNLOAD
Author : Angela N. Kaczmarczyk
language : en
Publisher:
Release Date : 2014
Germline Maintenance And Regeneration In The Amphipod Crustacean Parhyale Hawaiensis written by Angela N. Kaczmarczyk and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Because the germline eventually gives rise to gametes, which have the potential to become the next generation, it is arguably one of the most important cell types and understanding how the germline is specified and maintained throughout an organism's lifetime is a fundamental question in biology. This dissertation investigates the underlying mechanisms of germline specification, maintenance, and regeneration in the amphipod crustacean Parhyale hawaiensis. First I identified additional germline markers, Ph-piwi1, Ph-piwi2, Ph-tudor, and Ph-gustavus in Parhyale. Then I characterized the Parhyale adult germline stem cell (GSC) niche by using a combination of molecular markers (for germline and stem cell niche components) and using cell proliferation assays. I generated an antibody to Parhyale Vasa, which was instrumental in confidently identifying germline cells. In the Parhyale adult ovaries, this GSC niche likely resides within the germline ridge. Understanding where the putative GSC niche is important for evolutionary comparisons and can give clues as to how germline regeneration occurs. Finally, I investigate the potential role of bone morphogenetic protein (BMP) signaling in Parhyale germline maintenance and regeneration. This study provides insight into germline specification, the GSC niche, and adult regeneration in the amphipod crustacean, Parhyale hawaiensis.
Germline Stem Cells
DOWNLOAD
Author : Steven X. Hou
language : en
Publisher: Humana Press
Release Date : 2014-10-15
Germline Stem Cells written by Steven X. Hou and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-15 with Science categories.
In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.
Introduction To Epigenetics
DOWNLOAD
Author : Renato Paro
language : en
Publisher: Springer Nature
Release Date : 2021-03-23
Introduction To Epigenetics written by Renato Paro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Science categories.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Heritable Human Genome Editing
DOWNLOAD
Author : The Royal Society
language : en
Publisher: National Academies Press
Release Date : 2021-01-16
Heritable Human Genome Editing written by The Royal Society and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-16 with Medical categories.
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Human Genome Editing
DOWNLOAD
Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-13
Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-13 with Medical categories.
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.
Male Germline Stem Cells Developmental And Regenerative Potential
DOWNLOAD
Author : Kyle E. Orwig
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-16
Male Germline Stem Cells Developmental And Regenerative Potential written by Kyle E. Orwig and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Science categories.
Scientists investigating germ cells have, over the past 15 years, originated discoveries and innovations that give us valuable insights into the mechanisms that regulate not just stem cell function, but human development in its widest sense. With contributions from some of the leading researchers in the field, Male Germline Stem Cells: Developmental and Regenerative Potential assesses the implications of these discoveries for understanding the fundamental biology of germline stem cells as well as their potential for human stem cell-based therapies. This monograph covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all. It is a reference point for any scientist involved in related research as well as being a timely summation of what could prove to be a hugely exciting and very fruitful area of inquiry.
Safety Of Genetically Engineered Foods
DOWNLOAD
Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2004-07-08
Safety Of Genetically Engineered Foods written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-07-08 with Science categories.
Assists policymakers in evaluating the appropriate scientific methods for detecting unintended changes in food and assessing the potential for adverse health effects from genetically modified products. In this book, the committee recommended that greater scrutiny should be given to foods containing new compounds or unusual amounts of naturally occurring substances, regardless of the method used to create them. The book offers a framework to guide federal agencies in selecting the route of safety assessment. It identifies and recommends several pre- and post-market approaches to guide the assessment of unintended compositional changes that could result from genetically modified foods and research avenues to fill the knowledge gaps.
What Is Regeneration
DOWNLOAD
Author : Jane Maienschein
language : en
Publisher: University of Chicago Press
Release Date : 2022-04-06
What Is Regeneration written by Jane Maienschein and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-06 with Science categories.
Two historians and philosophers of science offer an essential primer on the meaning and limits of regeneration. In punishment for his stealing fire, the Greek gods chained Prometheus to a rock, where every day an eagle plucked out his liver, and every night the liver regenerated. While Prometheus may be a figure of myth, scholars today ask whether ancient Greeks knew that the human liver does, in fact, have a special capacity to regenerate. Some organs and tissues can regenerate, while others cannot, and some organisms can regenerate more fully and more easily than others. Cut an earthworm in half, and two wiggly worms may confront you. Cut off the head of a hydra, and it may grow a new head. Cut off a human arm, and the human will be missing an arm. Why the differences? What are the limits of regeneration, and how, when, and why does it occur? In this book, historians and philosophers of science Jane Maienschein and Kate MacCord explore biological regeneration, delving into a topic of increasing interest in light of regenerative medicine, new tools in developmental and neurobiology, and the urgent need to understand and repair damage to ecosystems brought on by climate change. Looking across scales, from germ, nerve, and stem cells to individual organisms and complex systems, this short and accessible introduction poses a range of deep and provocative questions: What conditions allow some damaged microbiomes to regenerate where others do not? Why are forests following a fire said to regenerate sometimes but not always? And in the face of climate change in the era called the Anthropocene, can the planet regenerate to become healthy again, or will the global ecosystem collapse?
Planarian Regeneration
DOWNLOAD
Author : Jochen C. Rink
language : en
Publisher: Humana
Release Date : 2018-06-19
Planarian Regeneration written by Jochen C. Rink and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-19 with Science categories.
This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
