Human Senescence
DOWNLOAD
Download Human Senescence PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Human Senescence book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Human Senescence
DOWNLOAD
Author : Douglas E. Crews
language : en
Publisher: Cambridge University Press
Release Date : 2003-12-11
Human Senescence written by Douglas E. Crews and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-11 with Science categories.
Much research on the biology of senescence is on cell-lines, nematodes or fruit flies, that are only of peripheral relevance to the problems encountered in humans. Human Senescence is a text which reviews the evolutionary biology of human senescence and life span, and the evolutionarily recent development of late-life survival. It examines how human patterns of and variability in growth and development have altered later life survival probabilities and competencies, and how survival during mid-life contributes to senescent dysfunction and alteration. Discussing possibilities of further extending human life span, it gives a better understanding of how humans came to senesce as slowly as we do over our lifespan. Bringing together gerontological, anthropological and biocultural research, it explores human variation in chronic disease, senescence and life span as outcomes of early life adaptation and the success of humankind's sociocultural evolution. It is a benchmark publication for all interested in how and why we age.
Cells Aging And Human Disease
DOWNLOAD
Author : Michael B. Fossel M.D.
language : en
Publisher: Oxford University Press
Release Date : 2004-06-10
Cells Aging And Human Disease written by Michael B. Fossel M.D. and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-10 with Medical categories.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Human Aging
DOWNLOAD
Author : Calogero Caruso
language : en
Publisher: Academic Press
Release Date : 2021-05-11
Human Aging written by Calogero Caruso and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-11 with Science categories.
Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Time Of Our Lives
DOWNLOAD
Author : Tom Kirkwood
language : en
Publisher: Oxford University Press
Release Date : 2001-01-11
Time Of Our Lives written by Tom Kirkwood and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-11 with Science categories.
By the year 2050 one in five of the world's population will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood draws on more than twenty years of research to make sense of the evolution of aging, to explain how aging occurs, and to answer fundamental questions like why women live longer than men. He shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.
Cells Aging And Human Disease
DOWNLOAD
Author : Michael B. Fossel M.D.
language : en
Publisher: Oxford University Press
Release Date : 2004-06-10
Cells Aging And Human Disease written by Michael B. Fossel M.D. and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-10 with Science categories.
Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Senescence
DOWNLOAD
Author : Warren Nichols
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Senescence written by Warren Nichols and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This monograph, Senescence; Dominant or Recessive In Somatic Cell Crosses? represents the second annual workshop to promote theory and concept development in aging research. These workshops are part of a resource to bank cultured cells of special interest to aging research that was established at the Institute for Medical Research in Camden. New Jersey. by the National Institute on Aging in 1974. The underlying theme of the workshops is the use of cultured cells in a variety of somatic cell genetic systems designed to define mechanisms of in vitra cellular scen escence and the possible insights that this may provide to the problems of in viva aging. The concept also includes bringing together workers from a variety of disciplines to stimulate new and innovative thoughts and work in the area. The current work shop focuses on the relative role of nucleus and cytoplasm on determining the in vitra lifespan of human diploid cells as well as the relative influence of old and young cells when combined within a single cell structure. The techniques and procedures discussed should make significant contributions to understanding in vitra senescence and may lead to the mapping of an area or areas of the genome linked to senescence as is being accomplished with viral transformation of normal cells. Warren W. Nichols Donald G. Murphy ~i Contents Theoretic Mechanisms of in vitpo Senescence 1 F. MaPott Sinex . . . . . . . . . . . . Senescence in Ce1l Cu1ture: An Accumu1ation of Errors or Terminal Differentiation? 13 Vincent J. GPistofaZo . . . . . . . . . . . . . .
Senescence In Humans
DOWNLOAD
Author : Brandon Chesser
language : en
Publisher:
Release Date : 2015-03-04
Senescence In Humans written by Brandon Chesser and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-04 with Science categories.
The phenomenon related to ageing in human beings is explained in this book. It covers various aspects relating to ageing and discusses the factors associated with it. Renowned experts and researchers in the field of senescence have made their valuable contributions to this book. It aims to benefit students and researchers interested in this field.
Ending Aging
DOWNLOAD
Author : Aubrey de Grey
language : en
Publisher: St. Martin's Griffin
Release Date : 2008-10-14
Ending Aging written by Aubrey de Grey and has been published by St. Martin's Griffin this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-14 with Science categories.
With a New Afterword Must We Age? Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine’s fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that -damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.
A Means To An End
DOWNLOAD
Author : William R. Clark
language : en
Publisher: Oxford University Press, USA
Release Date : 2002
A Means To An End written by William R. Clark and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Family & Relationships categories.
Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.
Aging Of Cells In And Outside The Body
DOWNLOAD
Author : S. Kaul
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Aging Of Cells In And Outside The Body written by S. Kaul and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Science categories.
This book provides updated knowledge on the basic features and mechanisms of cellular aging established since its first manifestation at cellular level 40 years ago. Contributions of genetic and environmental factors, failure of genetic and cellular repair mechanisms, and the epigenetic modifications determine the final lifespan of cells. This book also provides an understanding on how aging mechanisms in mice, a most frequently used model, differ with that of humans who receive better tumor surveillance because of stringent controls on aging mechanisms. It also appraises the use of modern technology for aging studies and its intervention. This book serves as an excellent reading on cellular aging for undergraduate students, researchers and experts of this area.