Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Author : Christoph Herwig
language : en
Publisher: MDPI
Release Date : 2018-03-23
Hybrid Modelling And Multi Parametric Control Of Bioprocesses written by Christoph Herwig and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with Electronic books categories.
This book is a printed edition of the Special Issue "Hybrid Modelling and Multi-Parametric Control of Bioprocesses" that was published in Bioengineering
Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Author : Christoph Herwig (Ed.)
language : en
Publisher:
Release Date : 2018
Hybrid Modelling And Multi Parametric Control Of Bioprocesses written by Christoph Herwig (Ed.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biology (General) categories.
The goal of bioprocessing is to optimize process variables, such as product quantity and quality, in a reproducible, scalable, and transferable manner. However, bioprocesses are highly complex. A large number of process parameters and raw material attributes exist, which are highly interactive, and may vary from batch to batch. Those interactions need to be understood, and the source of variance must be identified and controlled.While purely data-driven correlations, such as chemometric models of spectroscopic data, may be employed for the understanding how process parameters are related to process variables, they can hardly be deployed outside of the calibration space. Currently, mechanistic models, models based on mechanistic links and first principles, are in the focus of development. They are perceived to allow transferability and scalability, because mechanistics can be extrapolated. Moreover, the models deliver a large range of hardly-measureable states and physiological parameters.The current Special Issue wants to display current solutions and case studies of development and deployment of hybrid models and multi-parametric control of bioprocesses. It includes: •Models for Bioprocess Monitoring•Model for Bioreactor Design and Scale Up•Hybrid model solutions, combinations of data driven and mechanistic models.•Model to unravel mechanistic physiological regulations•Implementation of hybrid models in the real-time context•Data science driven model for process validation and product life cycle management.
Hybrid Modeling In Process Industries
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Author : Jarka Glassey
language : en
Publisher: CRC Press
Release Date : 2018-02-01
Hybrid Modeling In Process Industries written by Jarka Glassey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-01 with Science categories.
This title introduces the underlying theory and demonstrates practical applications in different process industries using hybrid modeling. It reviews hybrid modeling approach applicability in wide range of process industries, recommends how to increase hybrid model performance and throw Insights into cost efficient practices in modeling techniques Discusses advance process operation maximizing the benefits of available process knowledge and Includes real-life and practical case studies
Modelling Optimization And Control Of Biomedical Systems
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Author : Efstratios N. Pistikopoulos
language : en
Publisher: John Wiley & Sons
Release Date : 2017-10-26
Modelling Optimization And Control Of Biomedical Systems written by Efstratios N. Pistikopoulos and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-26 with Technology & Engineering categories.
Shows the newest developments in the field of multi-parametric model predictive control and optimization and their application for drug delivery systems This book is based on the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project, which was created to derive intelligent computer model-based systems for optimization of biomedical drug delivery systems in the cases of diabetes, anaesthesia, and blood cancer. These systems can ensure reliable and fast calculation of the optimal drug dosage without the need for an online computer—while taking into account the specifics and constraints of the patient model, flexibility to adapt to changing patient characteristics and incorporation of the physician’s performance criteria, and maintaining the safety of the patients. Modelling Optimization and Control of Biomedical Systems covers: mathematical modelling of drug delivery systems; model analysis, parameter estimation, and approximation; optimization and control; sensitivity analysis & model reduction; multi-parametric programming and model predictive control; estimation techniques; physiologically-based patient model; control design for volatile anaesthesia; multiparametric model based approach to intravenous anaesthesia; hybrid model predictive control strategies; Type I Diabetes Mellitus; in vitro and in silico block of the integrated platform for the study of leukaemia; chemotherapy treatment as a process systems application; and more. Introduces readers to the Modelling, Control and Optimization of Biomedical Systems (MOBILE) project Presents in detail the theoretical background, computational tools, and methods that are used in all the different biomedical systems Teaches the theory for multi-parametric mixed-integer programming and explicit optimal control of volatile anaesthesia Provides an overview of the framework for modelling, optimization, and control of biomedical systems This book will appeal to students, researchers, and scientists working on the modelling, control, and optimization of biomedical systems and to those involved in cancer treatment, anaesthsia, and drug delivery systems.
Control In Bioprocessing
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Author : Pablo A. López Pérez
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-10
Control In Bioprocessing written by Pablo A. López Pérez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-10 with Technology & Engineering categories.
Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.
New Directions In Bioprocess Modeling And Control
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Author : Michael A. Boudreau
language : en
Publisher: ISA
Release Date : 2007
New Directions In Bioprocess Modeling And Control written by Michael A. Boudreau and has been published by ISA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
Models offer benefits even before they are put on line. Based on years of experience, the authors reveal in New Directions in Bioprocess Modeling and Control that significant improvements can result from the process knowledge and insight that are gained when building experimental and first-principle models for process monitoring and control. Doing modeling in the process development and early commercialization phases is advantageous because it increases process efficiency and provides ongoing opportunities for improving process control. This technology is important for maximizing benefits from analyzers and control tool investments. If you are a process design, quality control, information systems, or automation engineer in the biopharmaceutical, brewing, or bio-fuel industry, this handy resource will help you define, develop, and apply a virtual plant, model predictive control, first-principle models, neural networks, and multivariate statistical process control. The synergistic knowledge discovery on bench top or pilot plant scale can be ported to industrial scale processes. This learning process is consistent with the intent in the Process Analyzer and Process Control Tools sections of the FDA_s Guidance for Industry PAT _ A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance. It states in the Process Analyzer section of the FDA_s guidance: _For certain applications, sensor-based measurements can provide a useful process signature that may be related to the underlying process steps or transformations. Based on the level of process understanding these signatures may also be useful for the process monitoring, control, and end point determination when these patterns or signatures relate to product and process quality._
16th European Symposium On Computer Aided Process Engineering And 9th International Symposium On Process Systems Engineering
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Author : Wolfgang Marquardt
language : en
Publisher: Elsevier
Release Date : 2006-08-02
16th European Symposium On Computer Aided Process Engineering And 9th International Symposium On Process Systems Engineering written by Wolfgang Marquardt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-02 with Technology & Engineering categories.
This proceedings book contains the papers presented at the joint conference event of the 9th Symposium on Process Systems Engineering (PSE'2006) and the 16th European Symposium on Computer Aided Process Engineering (ESCAPE-16), held in Garmisch-Partenkirchen, Germany, from July 9 – July 13, 2006. The symposium follows the first joint event PSE’97 / ESCAPE-7 in Trondheim, Norway (1997). The last two venues of the ESCAPE symposia were Barcelona, Spain (2005) and Lisbon, Portugal (2004) and the most recent PSE symposia were held in Kunming, China (2003) and Keystone, Colorado, USA (2000). The purpose of both series is to bring together the international community of researchers engineers who are interested in computing-based methods in process engineering. The main objective of the symposium is to review and present the latest developments and current state in Process Systems Engineering and Computer Aided Process Engineering. The focus of PSE’2006 / ESCAPE-16 has been on Modelling and Numerical Methods, Product and Process Design, Operations and Control, Biological Systems, Infrastructure Systems, and Business decision support. * reviews and presents the latest developments and current state of Process Systems Engineering and Computer Aided Process Engineering * contains papers presented at a joint conference event * bringing together an international community of researchers and engineers interested in computing-based methods in Process Engineering
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control
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Author : Maria Carmo Nicoletti
language : en
Publisher: Springer
Release Date : 2009-07-09
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control written by Maria Carmo Nicoletti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-09 with Technology & Engineering categories.
Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.
Automatic Control Of Bioprocesses
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Author : Denis Dochain
language : en
Publisher: Wiley-ISTE
Release Date : 2008-08-25
Automatic Control Of Bioprocesses written by Denis Dochain and has been published by Wiley-ISTE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-25 with Science categories.
Giving an overview of the challenges in the control of bioprocesses, this comprehensive book presents key results in various fields, including: dynamic modeling; dynamic properties of bioprocess models; software sensors designed for the on-line estimation of parameters and state variables; control and supervision of bioprocesses.
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts
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Author : Claire Komives
language : en
Publisher: John Wiley & Sons
Release Date : 2018-12-27
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts written by Claire Komives and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-27 with Science categories.
Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies