Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Author : Christoph Herwig
language : en
Publisher: MDPI
Release Date : 2018-03-23
Hybrid Modelling And Multi Parametric Control Of Bioprocesses written by Christoph Herwig and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with Science categories.
This book is a printed edition of the Special Issue "Hybrid Modelling and Multi-Parametric Control of Bioprocesses" that was published in Bioengineering
Hybrid Modelling And Multi Parametric Control Of Bioprocesses
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Author : Christoph Herwig (Ed.)
language : en
Publisher:
Release Date : 2018
Hybrid Modelling And Multi Parametric Control Of Bioprocesses written by Christoph Herwig (Ed.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biology (General) categories.
The goal of bioprocessing is to optimize process variables, such as product quantity and quality, in a reproducible, scalable, and transferable manner. However, bioprocesses are highly complex. A large number of process parameters and raw material attributes exist, which are highly interactive, and may vary from batch to batch. Those interactions need to be understood, and the source of variance must be identified and controlled.While purely data-driven correlations, such as chemometric models of spectroscopic data, may be employed for the understanding how process parameters are related to process variables, they can hardly be deployed outside of the calibration space. Currently, mechanistic models, models based on mechanistic links and first principles, are in the focus of development. They are perceived to allow transferability and scalability, because mechanistics can be extrapolated. Moreover, the models deliver a large range of hardly-measureable states and physiological parameters.The current Special Issue wants to display current solutions and case studies of development and deployment of hybrid models and multi-parametric control of bioprocesses. It includes: •Models for Bioprocess Monitoring•Model for Bioreactor Design and Scale Up•Hybrid model solutions, combinations of data driven and mechanistic models.•Model to unravel mechanistic physiological regulations•Implementation of hybrid models in the real-time context•Data science driven model for process validation and product life cycle management.
Hybrid Modeling In Process Industries
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Author : Jarka Glassey
language : en
Publisher: CRC Press
Release Date : 2018-02-01
Hybrid Modeling In Process Industries written by Jarka Glassey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-01 with Science categories.
This title introduces the underlying theory and demonstrates practical applications in different process industries using hybrid modeling. It reviews hybrid modeling approach applicability in wide range of process industries, recommends how to increase hybrid model performance and throw Insights into cost efficient practices in modeling techniques Discusses advance process operation maximizing the benefits of available process knowledge and Includes real-life and practical case studies
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control
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Author : Maria Carmo Nicoletti
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-29
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control written by Maria Carmo Nicoletti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with Mathematics categories.
Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.
16th European Symposium On Computer Aided Process Engineering And 9th International Symposium On Process Systems Engineering
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Author : Wolfgang Marquardt
language : en
Publisher: Elsevier
Release Date : 2006-08-02
16th European Symposium On Computer Aided Process Engineering And 9th International Symposium On Process Systems Engineering written by Wolfgang Marquardt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-02 with Science categories.
This proceedings book contains the papers presented at the joint conference event of the 9th Symposium on Process Systems Engineering (PSE'2006) and the 16th European Symposium on Computer Aided Process Engineering (ESCAPE-16), held in Garmisch-Partenkirchen, Germany, from July 9 – July 13, 2006. The symposium follows the first joint event PSE'97 / ESCAPE-7 in Trondheim, Norway (1997). The last two venues of the ESCAPE symposia were Barcelona, Spain (2005) and Lisbon, Portugal (2004) and the most recent PSE symposia were held in Kunming, China (2003) and Keystone, Colorado, USA (2000). The purpose of both series is to bring together the international community of researchers engineers who are interested in computing-based methods in process engineering. The main objective of the symposium is to review and present the latest developments and current state in Process Systems Engineering and Computer Aided Process Engineering. The focus of PSE'2006 / ESCAPE-16 has been on Modelling and Numerical Methods, Product and Process Design, Operations and Control, Biological Systems, Infrastructure Systems, and Business decision support.* reviews and presents the latest developments and current state of Process Systems Engineering and Computer Aided Process Engineering * contains papers presented at a joint conference event * bringing together an international community of researchers and engineers interested in computing-based methods in Process Engineering
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts
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Author : Claire Komives
language : en
Publisher: John Wiley & Sons
Release Date : 2018-12-27
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts written by Claire Komives and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-27 with Science categories.
Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
Machine Learning And Hybrid Modelling For Reaction Engineering
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Author : Dongda Zhang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2023-12-20
Machine Learning And Hybrid Modelling For Reaction Engineering written by Dongda Zhang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-20 with Science categories.
Over the last decade, there has been a significant shift from traditional mechanistic and empirical modelling into statistical and data-driven modelling for applications in reaction engineering. In particular, the integration of machine learning and first-principle models has demonstrated significant potential and success in the discovery of (bio)chemical kinetics, prediction and optimisation of complex reactions, and scale-up of industrial reactors. Summarising the latest research and illustrating the current frontiers in applications of hybrid modelling for chemical and biochemical reaction engineering, Machine Learning and Hybrid Modelling for Reaction Engineering fills a gap in the methodology development of hybrid models. With a systematic explanation of the fundamental theory of hybrid model construction, time-varying parameter estimation, model structure identification and uncertainty analysis, this book is a great resource for both chemical engineers looking to use the latest computational techniques in their research and computational chemists interested in new applications for their work.
Process Control Intensification And Digitalisation In Continuous Biomanufacturing
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Author : Ganapathy Subramanian
language : en
Publisher: John Wiley & Sons
Release Date : 2021-12-20
Process Control Intensification And Digitalisation In Continuous Biomanufacturing written by Ganapathy Subramanian and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-20 with Technology & Engineering categories.
Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing Explore new trends in continuous biomanufacturing with contributions from leading practitioners in the field With the increasingly widespread acceptance and investment in the ??technology, the last decade has demonstrated the utility of continuous ??processing in the pharmaceutical industry. In Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing, distinguished biotechnologist Dr. Ganapathy Subramanian delivers a comprehensive exploration of the potential of the continuous processing of biological products and discussions of future directions in advancing continuous processing to meet new challenges and demands in the manufacture of therapeutic products. A stand-alone follow-up to the editor’s Continuous Biomanufacturing: Innovative Technologies and Methods published in 2017, this new edited volume focuses on critical aspects of process intensification, process control, and the digital transformation of biopharmaceutical processes. In addition to topics like the use of multivariant data analysis, regulatory concerns, and automation processes, the book also includes: Thorough introductions to capacitance sensors to control feeding strategies and the continuous production of viral vaccines Comprehensive explorations of strategies for the continuous upstream processing of induced microbial systems Practical discussions of preparative hydrophobic interaction chromatography and the design of modern protein-A-resins for continuous biomanufacturing In-depth examinations of bioprocess intensification approaches and the benefits of single use for process intensification Perfect for biotechnologists, bioengineers, pharmaceutical engineers, and process engineers, Process Control, Intensification, and Digitalisation in Continuous Biomanufacturing is also an indispensable resource for chemical engineers seeking a one-stop reference on continuous biomanufacturing.
Artificial Intelligence And Biological Sciences
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Author : P.V. Mohanan
language : en
Publisher: CRC Press
Release Date : 2025-06-17
Artificial Intelligence And Biological Sciences written by P.V. Mohanan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-17 with Computers categories.
Advancements of AI in medical and biological sciences have opened new ways for drug development. Novel therapeutic molecules and their target action can be easily predicted and can be modified. AI helps in disease detection and diagnosis faster. The breakthrough of AI is made especially in the area of personalized precision medicine, host-pathogen interaction and predictive epidemiology. These approaches could help in faster decision-making with minimal errors that can improve risk analysis, especially disease diagnosis and selecting treatment strategy. In agricultural practices, an exact combination of fertilizers, pesticides, herbicides, soil management, water requirement analysis, yield prediction and overall crop management can be modified by implementing AI interventions. AI could provide a better improvement in agriculture, medical research, pharmaceuticals and bio-based industries for a sustainable life. The key features of this book are: AI in medical Sciences, biotechnology and drug discovery; Application of AI in Digital Pathology, cytology and bioinformatics; Overview of AI, Machine Learning and Deep Learning; Impact of Artificial Intelligence in Society; Artificial Intelligence in Pharmacovigilance; and Ethics in Artificial Intelligence. The volume aims to comprehensively cover the application of AI in biological sciences. It is a collection of contributions from different authors who have several years of experience in their specific areas. The book will be useful for pharma companies, CROs, product developers, students, researchers, academicians, policymakers and practitioners.
Digital Twins
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Author : Christoph Herwig
language : en
Publisher: Springer Nature
Release Date : 2021-04-25
Digital Twins written by Christoph Herwig and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-25 with Technology & Engineering categories.
This is the first of two volumes that together provide an overview of the latest advances in the generation and application of digital twins in bioprocess design and optimization. Both processes have undergone significant changes over the past few decades, moving from data-driven approaches into the 21st-century digitalization of the bioprocess industry. Moreover, the high demand for biotechnological products calls for efficient methods during research and development, as well as during tech transfer and routine manufacturing. In this regard, one promising tool is the use of digital twins, which offer a virtual representation of the bioprocess. They reflect the mechanistics of the biological system and the interactions between process parameters, key performance indicators and product quality attributes in the form of a mathematical process model. Furthermore, digital twins allow us to use computer-aided methods to gain an improved process understanding, to test and plan novel bioprocesses, and to efficiently monitor them. This book explains the mathematical structure of digital twins, their development and the model’s respective parts, as well as concepts for the knowledge-driven generation and structural variability of digital twins. Covering fundamentals as well as applications, the two volumes offer the ideal introduction to the topic for researchers in academy and industry alike.