Hyperglycemia Diabetes And Vascular Disease
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Hyperglycemia Diabetes And Vascular Disease
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Author : Neil Ruderman
language : en
Publisher: Springer
Release Date : 2013-05-27
Hyperglycemia Diabetes And Vascular Disease written by Neil Ruderman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Medical categories.
It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.
Diabetes And Vascular Disease
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Author : Morris D. Kerstein
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1990
Diabetes And Vascular Disease written by Morris D. Kerstein and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Health & Fitness categories.
Diabetes And Cardiovascular Disease
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Author : Francesco Paneni
language : en
Publisher: Springer
Release Date : 2015-06-23
Diabetes And Cardiovascular Disease written by Francesco Paneni and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-23 with Medical categories.
This book provides a practical hands-on approach to the management of patients with diabetes and cardiovascular disease, with original and up-to-date coverage of a variety of aspects of emerging clinical importance. Practical advice is offered on diagnosis, risk stratification, management of cardiovascular risk factors and available drug therapies. Appropriate myocardial revascularization strategies are explained and the current state of knowledge is documented regarding target-led multifactorial treatment and the management of acute coronary syndromes, heart failure, and cerebrovascular disease. New algorithms for diagnosis and treatment are presented and to ensure ease of reference each chapter includes a box with practical recommendations as well as informative color illustrations and tables. The handbook will be of value for all cardiologists and diabetologists and will be especially helpful for young cardiologists, who are ever more frequently confronted by patients with diabetes and cardiovascular disease.
Mechanisms Of Vascular Defects In Diabetes Mellitus
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Author : C.C. Kartha
language : en
Publisher: Springer
Release Date : 2017-08-01
Mechanisms Of Vascular Defects In Diabetes Mellitus written by C.C. Kartha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-01 with Science categories.
This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality. In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia. In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers. The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section. The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes. Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes. Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here. The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.“/div>divWe intend to invite authors who symbolize a multidisciplinary approach to this complicated disease. The proposed authors include clinicians who understand the trend of vascular complications in their long term clientele, epidemiologists with a holistic view, basic and experimental researchers with years of experience in dissecting the factors leading to endothelial dysfunction and clinical researchers with the skill of translating bench work to the bedside. We expect this book will be of significant value and interest to the same group of clinicians, researchers, post doctoral fellows and medical and non medical graduate students. The novel assimilated insights could stimulate development of mechanism based prevention and therapeutic strategies providing a promising option to limit cardiovascular complications in diabetes mellitus.
Diabetes And Cardiovascular Disease
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Author : Michael Johnstone
language : en
Publisher: Springer Nature
Release Date : 2023-06-01
Diabetes And Cardiovascular Disease written by Michael Johnstone and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-01 with Medical categories.
This third edition of the book offers an up-to-date review of Diabetes Mellitus with a focus on both Micro- and Macrovascular Disease. The text includes a review of the basic concepts of : Diabetes and Vascular Disease, including Endothelial Dysfunction; The Effect of Insulin on the Vascular System; The Mechanism of Atherosclerosis in Diabetes Mellitus and the Role of Inflammation on the Vascular Tree; and The Role of the Renin-Angiotensin-Aldosteronism on Diabetes Mellitus. Chapters will discuss the Genetics of Type 2 Diabetes Mellitus as well as the Metabolic Syndrome. Other chapters discuss the Risk Factors of Diabetes and Vascular Disease, including Hypertension; Dyslipidemia; and Thrombosis. The book also reviews Microcirculation; Diabetic Nephropathy; Diabetic Retinopathy; as well as the Epidemiology, Diagnosis, and Treatment of Peripheral Vascular Disease; Diabetes and Coronary Artery Disease; Diabetes and Percutaneous Interventions; Diabetes and Cardiac Surgery; and Diabetes and Heart Failure. Chapters conclude with a review of the present-day Treatment of the Diabetic Patient. Diabetes and Cardiovascular Disease, 3rd Edition, offers practicing physicians a cutting-edge scientific and clinical review of diabetic cardiovascular disease, providing both a deeper understanding of its pathology and all the day-to-day practical knowledge needed to treat patients effectively.
Diabetes And Peripheral Vascular Disease
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Author : Gautam V. Shrikhande
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Diabetes And Peripheral Vascular Disease written by Gautam V. Shrikhande and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
In Diabetes and Peripheral Vascular Disease, a panel of distinguished leaders in the field of medicine, podiatry, and vascular and endovascular therapy assimilate the latest literature on these issues and others for an in-depth review of the management of peripheral vascular disease. Providing an overview of the management of diabetes and diabetic foot changes as well as providing a view of cutting-edge and emerging topics in optimization of arterial status, this important title addresses pathophysiology, anatomy, diagnosis and management of diabetic peripheral vascular disease, emphasizing a multi-disciplinary approach. The first chapter of the book provides an overview of this complex disease process and discusses the teamwork required for optimal management. The chapters continue with the basic pathophysiology of diabetic atherosclerosis and a contemporary review of the management of diabetes. The genesis of diabetic foot ulceration and prevention and management strategies is covered, as is the effects of neuropathy and microvascular changes in the diabetic foot. In addition, Diabetes and Peripheral Vascular Disease covers the microbiology of diabetic foot infections, the role of endovascular interventions and vascular surgery as well as the management of the complications of these procedures, the process of amputation for those patients who have progressed beyond a limb salvage situation, and the effects of diabetes on the cerebrovascular system as well as its implications in patients with aortoiliac disease. An invaluable addition to the literature on diabetes and peripheral vascular disease, the book will be of great interest internists, family practitioners, surgeons, podiatrists, wound care specialists, and vascular specialists. Students, residents, and fellows in surgical and medical specialties should also find this book of significant value and interest.
Hyperglycemia
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Author : Bosko Nikolic
language : en
Publisher: Nova Science Publishers
Release Date : 2012
Hyperglycemia written by Bosko Nikolic and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Diabetes categories.
Hyperglycemia is the central metabolic abnormality in diabetes mellitus and it serves as the basis for making the diagnosis in both type 1 and type 2 diabetes. In this book, the authors present topical research in the study of the causes, symptoms and treatment options for hyperglycemia. Topics discussed include the ethiopathogenesis of stress hyperglycemia and its observation in acute coronary syndrome (ACS); developmental programming of hyperglycemia and metabolic outcomes; the role of hyperglycemia in diabetic nephropathy; and management of hyperglycemia in diabetic vascular disease.
Epidemiology Of Diabetes And Its Vascular Lesions
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Author : Kelly M. West
language : en
Publisher: Elsevier Publishing Company
Release Date : 1978
Epidemiology Of Diabetes And Its Vascular Lesions written by Kelly M. West and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Health & Fitness categories.
Medical Management Of Diabetes And Heart Disease
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Author : Burton E. Sobel
language : en
Publisher: CRC Press
Release Date : 2002-03-06
Medical Management Of Diabetes And Heart Disease written by Burton E. Sobel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-06 with Medical categories.
This state-of-the-art reference details current and effective symptom-specific strategies for the diagnosis and management of diabetic patients-emphasizing the exploration of therapeutic options available for the treatment of accelerated coronary complications associated with diabetes. Addresses the pathophysiology underlying advanced heart
Diabetes In Cardiovascular Disease A Companion To Braunwald S Heart Disease E Book
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Author : Darren K McGuire
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-08-27
Diabetes In Cardiovascular Disease A Companion To Braunwald S Heart Disease E Book written by Darren K McGuire and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-27 with Medical categories.
Diabetes in Cardiovascular Disease is a current, expert resource focusing on the complex challenges of providing cardiovascular care to patients with diabetes. Designed as a companion to Braunwald’s Heart Disease, this interdisciplinary medical reference book bridges the gap between the cardiology and endocrinology communities of scientists and care providers, and highlights the emerging scientific and clinical topics that are relevant for cardiologists, diabetologists/endocrinologists, and the extended diabetes care team. Access essential coverage of basic and clinical sciences, complemented by an expanded focus on epidemiology, behavioral sciences, health policy, and disparities in health care. Take advantage of a format that follows that of the well-known and internationally recognized Braunwald’s Heart Disease. Review the best available clinical data and pragmatic recommendations for the prevention and management of cardiovascular complications of diabetes; national/societal intervention strategies to curb the growing prevalence of diabetes; and the current pathophysiological understanding of cardiovascular comorbidities in patients with diabetes. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.