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Igf And Nutrition In Health And Disease
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Author : M. Sue Houston
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-04
Igf And Nutrition In Health And Disease written by M. Sue Houston and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-04 with Medical categories.
A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Igf I And Igf Binding Proteins
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Author : Stefano Cianfarani
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Igf I And Igf Binding Proteins written by Stefano Cianfarani and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Science categories.
The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a symposium entitled 'IGFs and IGFBPs: Assessment and Therapeutic Benefit'. Highly qualified basic scientists and endocrinologists report new advances in the broad field of IGF physiology and pathophysiology, related to clinical medicine. New and topical areas of the IGF field are covered, focussing particularly on clinically relevant topics related to growth, pediatric and adult growth hormone deficiency, metabolic disorders, diabetes mellitus and neurology. Molecular and developmental defects are discussed, as are the contributions to clinical diagnosis and management of measurement of IGFs and IGFBPs. The therapeutic potential of recombinant human IGFs and IGFBPs in a range of disorders is also covered. The present volume of Endocrine Development will be of particular interest to scientists and clinicians working in IGF and IGF-related fields and to clinicians working in both pediatric and adult endocrinology and metabolism.
The Igf System
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Author : Ron G. Rosenfeld
language : en
Publisher: Humana
Release Date : 2010-11-09
The Igf System written by Ron G. Rosenfeld and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-09 with Medical categories.
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.
Biology Of Igf 1
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-10
Biology Of Igf 1 written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-10 with Medical categories.
An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.
Ghrh Gh And Igf I
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Author : Marc R. Blackman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Ghrh Gh And Igf I written by Marc R. Blackman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Recent research suggests that adult growth hormone (GH) deficiency, whether of pathological or physiological origin, is associated with a dis tinct syndrome that includes alterations in body composition, endocrine metabolic function, immune competence, and physical and psychosocial well-being. Not surprisingly, substantial investigative effort is currently focused on validating the above hypothesis and on determining whether restoration of a normal GH-IGF-I axis in various states of adult GH deficiency is clinically useful, safe, and cost-beneficial. This book contains the proceedings from the Symposium on GHRH, GH, and IGF-I: Basic and Clinical Advances, held December 9 to 12, 1993, in San Diego, California, and sponsored by Serono Symposia USA, Inc. The conference was meant to highlight selected novel and exciting clinical research developments related to possible therapeutic uses of recombinant human GH and IGF-I, GHRH, GH releasing peptides, and related GH secretagogues. This meeting occurred only one year after a similar Serono symposium that was somewhat more oriented to novel basic science discoveries, thus attesting to the current scientific and clinical interest in this area.
Current Perspectives On Insulin Like Growth Factor Binding Protein Igfbp Research
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Author : Andreas Hoeflich
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
Current Perspectives On Insulin Like Growth Factor Binding Protein Igfbp Research written by Andreas Hoeflich and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.
The Role Of The Igf Insulin Igfbp Axis In Normal Physiology And Disease
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Author : Claire Perks
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-17
The Role Of The Igf Insulin Igfbp Axis In Normal Physiology And Disease written by Claire Perks and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-17 with Medical categories.
Anabolic And Metabolic Effects Of Insulin Like Growth Factor I Igf I And Growth Hormone Gh During Total Parenteral Nutrition Tpn In Rats
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Author : Hui-Chen Paula Lo
language : en
Publisher:
Release Date : 1996
Anabolic And Metabolic Effects Of Insulin Like Growth Factor I Igf I And Growth Hormone Gh During Total Parenteral Nutrition Tpn In Rats written by Hui-Chen Paula Lo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Insulin Like Growth Factors In Development Cancers And Aging
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Author : Haim Werner
language : en
Publisher: MDPI
Release Date : 2021-08-30
Insulin Like Growth Factors In Development Cancers And Aging written by Haim Werner and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-30 with Science categories.
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Igfs In The Nervous System
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Author : E. E. Müller
language : en
Publisher: Springer
Release Date : 1998
Igfs In The Nervous System written by E. E. Müller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.