The Igf System
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The Igf System
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Author : Ron G. Rosenfeld
language : en
Publisher: Humana
Release Date : 2010-11-09
The Igf System written by Ron G. Rosenfeld and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-09 with Medical categories.
It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated.
Igf And Nutrition In Health And Disease
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Author : M. Sue Houston
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-04
Igf And Nutrition In Health And Disease written by M. Sue Houston and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-04 with Medical categories.
A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Igf I And Igf Binding Proteins
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Author : Stefano Cianfarani
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2005-01-01
Igf I And Igf Binding Proteins written by Stefano Cianfarani and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-01 with Science categories.
The IGF system pervades the fields of development, linear and cellular growth and metabolism. Not only is the functional integrity of the IGF system crucial for normal linear growth and metabolism, it is also of fundamental importance for normal fetal development. This book consists of a compilation of chapters based on presentations at a symposium entitled 'IGFs and IGFBPs: Assessment and Therapeutic Benefit'. Highly qualified basic scientists and endocrinologists report new advances in the broad field of IGF physiology and pathophysiology, related to clinical medicine. New and topical areas of the IGF field are covered, focussing particularly on clinically relevant topics related to growth, pediatric and adult growth hormone deficiency, metabolic disorders, diabetes mellitus and neurology. Molecular and developmental defects are discussed, as are the contributions to clinical diagnosis and management of measurement of IGFs and IGFBPs. The therapeutic potential of recombinant human IGFs and IGFBPs in a range of disorders is also covered. The present volume of Endocrine Development will be of particular interest to scientists and clinicians working in IGF and IGF-related fields and to clinicians working in both pediatric and adult endocrinology and metabolism.
Ontogenetic Development Of The Igf System And Leptin In Offspring Of Sows Fed With Gestation Diets Differing In Protein Content
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Author : Anika Steinhoff-Ooster
language : en
Publisher: Cuvillier Verlag
Release Date : 2012-03-26
Ontogenetic Development Of The Igf System And Leptin In Offspring Of Sows Fed With Gestation Diets Differing In Protein Content written by Anika Steinhoff-Ooster and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-26 with Science categories.
The aim of this dissertation was to characterize leptin and the different components of the IGF-system in offspring of sows fed with different protein contents throughout pregnancy and to ascertain long term consequences caused by an inadequate nutritional environment in utero. German Landrace gilts (n=78) were fed gestation diets (~15.4 MJ ME/kg) of either low (LP, 6%; n=26), adequate (AP, 12%; n=26), or high (HP, 30%; n=24) protein content. For sampling at day 94 of gestation, 26 gilts with their fetuses were investigated. At parturition, the offspring of the remaining 52 gilts were cross fostered to nursing sows fed a standard lactation diet. Fetal and birth weight of all investigated offspring were recorded and classified into 2 different fetal body weight classes (Fbwc ≤ or > 0.65 kg) or birth weight classes (Bbwc ≤ or > 1.3 kg). In addition, the litter size of any gilt was classified into two groups (Lsgr ≤ or > 12 piglets). Blood and liver samples from 306 piglets in total were collected. In detail, fetuses of day 94 of gestation (dpc), and piglets at their 1st, 28th and 188th day of life (dpn) were sampled. Blood samples were assayed for IGF-1, IGF-2 and leptin by ELISA and for IGF binding proteins via a quantitative, non-radioactive Western ligand blotting protocol established and optimized herein. Liver samples were assayed for IGF-1 receptor by use of ELISA. The concentrations of leptin in offspring were not affected by maternal diet over all postnatal days. With the exception of dpn 1, the IGF-1 concentrations remained unchanged in response to maternal dietary treatment. Piglets born to mothers fed the LP diet had decreased IGF-1 concentrations compared to piglets born to HP mothers (P
Current Perspectives On Insulin Like Growth Factor Binding Protein Igfbp Research
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Author : Andreas Hoeflich
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-06
Current Perspectives On Insulin Like Growth Factor Binding Protein Igfbp Research written by Andreas Hoeflich and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with categories.
The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.
Igfs In The Nervous System
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Author : E. E. Müller
language : en
Publisher: Springer
Release Date : 1998
Igfs In The Nervous System written by E. E. Müller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
In the last few years, considerable attention has been paid to the presence of insulin-like growth factors (IGFs) and their binding proteins (IGF-BPs) in the brain and peripheral neuronal tissue. IGFs are synthesized within the CNS, are bound to specific IGF-BPs and act on specific receptors. They represent a new class of growth factors and messengers in the brain and the periphery. Written by a group of outstanding experts in the field, the book provides an invaluable forum where important aspects of the production, regulation, biological actions, pathophysiological involvement, therapeutic applications for IGFs in many neurologic and neuromuscular disorders are addressed and critically evaluated.
Biology Of Igf 1
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Author : Novartis Foundation
language : en
Publisher: Wiley
Release Date : 2004-11-12
Biology Of Igf 1 written by Novartis Foundation and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-12 with Medical categories.
An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.
Comparative Studies On The Igf System In Vertebrates
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Author : Katarina Drakenberg
language : en
Publisher:
Release Date : 1996
Comparative Studies On The Igf System In Vertebrates written by Katarina Drakenberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Somatomedin categories.
Insulin Like Growth Factors In Health And Disease An Issue Of Endocrinology And Metabolism Clinics E Book
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Author : Claire M. Perks
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-07-03
Insulin Like Growth Factors In Health And Disease An Issue Of Endocrinology And Metabolism Clinics E Book written by Claire M. Perks and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-03 with Medical categories.
This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.
Insulin Like Growth Factor Receptor Signalling
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Insulin Like Growth Factor Receptor Signalling written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Medical categories.
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.