Insulin Like Growth Factor Receptor Signalling
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Insulin Like Growth Factor Receptor Signalling
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Insulin Like Growth Factor Receptor Signalling written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Medical categories.
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Biology Of Igf 1
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-10
Biology Of Igf 1 written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-10 with Medical categories.
An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as: the definition of danger zones the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin possible approaches to preventative intervention the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.
Insulin Like Growth Factors And Cancer
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-18
Insulin Like Growth Factors And Cancer written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-18 with Medical categories.
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Insulin Like Growth Factors In Development Cancers And Aging
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Author : Haim Werner
language : en
Publisher: MDPI
Release Date : 2021-08-30
Insulin Like Growth Factors In Development Cancers And Aging written by Haim Werner and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-30 with Science categories.
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Predictive Biomarkers In Oncology
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Author : Sunil Badve
language : en
Publisher: Springer
Release Date : 2018-12-06
Predictive Biomarkers In Oncology written by Sunil Badve and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-06 with Medical categories.
“Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.
Islets Of Langerhans 2 Ed
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Author : Shahidul Islam
language : en
Publisher:
Release Date :
Islets Of Langerhans 2 Ed written by Shahidul Islam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Bioorganic chemistry categories.
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System
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Author : Mohan Raizada
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System written by Mohan Raizada and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Nature categories.
Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.
Holland Frei Cancer Medicine
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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10
Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
The Growth Hormone Insulin Like Growth Factor Axis During Development
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Author : Isabel Varela-Nieto
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-17
The Growth Hormone Insulin Like Growth Factor Axis During Development written by Isabel Varela-Nieto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-17 with Medical categories.
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Insulin Receptor Substrate Signaling In The Central Nervous System
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Author : Susanna Freude
language : en
Publisher: Nova Science Publishers
Release Date : 2010
Insulin Receptor Substrate Signaling In The Central Nervous System written by Susanna Freude and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Cellular signal transduction categories.
Recent advance in molecular biology revealed new insights into the function of insulin receptor signalling and insulin receptor substrate (IRS) protein mediated signals in the central nervous system (CNS) in vivo. The IRS proteins mediate mainly intracellular effects of the insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor (IR). The functions of IRS proteins in peripheral tissues like muscle, liver, pancreas and fat have been characterised in detail. This book examines why IRS signalling is not only critical during brain development, but also for reproduction, energy homeostasis, ageing and possibly for neurodegenerative diseases in humans.