Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System
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Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System
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Author : Mohan Raizada
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System written by Mohan Raizada and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Nature categories.
Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.
The Role Of Insulin Like Growth Factors In The Nervous System
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Author : Mohan K. Raizada
language : en
Publisher:
Release Date : 1993
The Role Of Insulin Like Growth Factors In The Nervous System written by Mohan K. Raizada and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Central nervous system categories.
This volume discusses various aspects of the insulin-like growth factors (IGFs), their binding proteins and receptors. The emphasis is on identification of these important growth factors in the nervous system and their potential role in nervous tissue physiology. The IFGs are compared to other growth factors that are important in the nervous system, including nerve growth factor.
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Holland Frei Cancer Medicine
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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10
Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.
Basic Neurochemistry
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Author : George J. Siegel
language : en
Publisher: Lippincott Raven
Release Date : 1999
Basic Neurochemistry written by George J. Siegel and has been published by Lippincott Raven this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: CRC Press
Release Date : 1991-05-28
Insulin Like Growth Factors written by Derek LeRoith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-28 with Medical categories.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Insulin Receptor Substrate Signaling In The Central Nervous System
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Author : Susanna Freude
language : en
Publisher: Nova Science Publishers
Release Date : 2010
Insulin Receptor Substrate Signaling In The Central Nervous System written by Susanna Freude and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Cellular signal transduction categories.
Recent advance in molecular biology revealed new insights into the function of insulin receptor signalling and insulin receptor substrate (IRS) protein mediated signals in the central nervous system (CNS) in vivo. The IRS proteins mediate mainly intracellular effects of the insulin-like growth factor-1 receptor (IGF-1R) and the insulin receptor (IR). The functions of IRS proteins in peripheral tissues like muscle, liver, pancreas and fat have been characterised in detail. This book examines why IRS signalling is not only critical during brain development, but also for reproduction, energy homeostasis, ageing and possibly for neurodegenerative diseases in humans.
Current Directions In Insulin Like Growth Factor Research
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Author : Derek Leroith
language : en
Publisher:
Release Date : 1994-01-31
Current Directions In Insulin Like Growth Factor Research written by Derek Leroith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-31 with categories.
The Role Of The Insulin Like Growth Factor Family In The Nervous System
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Author : Hsin-Lin Cheng
language : en
Publisher:
Release Date : 1996
The Role Of The Insulin Like Growth Factor Family In The Nervous System written by Hsin-Lin Cheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.