Insulin Like Growth Factors
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Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: CRC Press
Release Date : 1991-05-28
Insulin Like Growth Factors written by Derek LeRoith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-28 with Medical categories.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.
Insulin Like Growth Factors In Development Cancers And Aging
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Author : Haim Werner
language : en
Publisher: MDPI
Release Date : 2021-08-30
Insulin Like Growth Factors In Development Cancers And Aging written by Haim Werner and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-30 with Science categories.
This Special Issue of Cells on “Insulin-Like Growth Factors in Development, Cancers and Aging” provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology.
Insulin Like Growth Factor Receptor Signalling
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Insulin Like Growth Factor Receptor Signalling written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Medical categories.
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
The Insulin Like Growth Factors
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Author : Paul N. Schofield
language : en
Publisher:
Release Date : 1992
The Insulin Like Growth Factors written by Paul N. Schofield and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
The past decade has seen an explosion in our understanding of the factors regulating cell proliferation and differentiation. One of the most exciting advances has been the recognition of the pivotal role of the peptide growth factors in these processes. The insulin-like growth factors, discovered in 1958 by Salmon and Daughaday, are now among the best characterized growth factors. This comprehensive work describes the recent advances in knowledge of their receptors and binding proteins together with their purification and cloning. This provides exciting insights into the role of these factors in the physiology of normal growth, embryonic development and areas of pathology such as wound healing and cancer. In this book an international group of contributors reviews the most up-to-date information on all aspects of the insulin-like growth factors, and critically discusses models for IGF action in their own systems. The book is a valuable source of information and ideas for researchers, and an accessible introduction to the subject for students and clinicians.
Growth Hormone And Insulin Like Growth Factor I In Human And Experimental Diabetes
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Author : Allan Flyvbjerg
language : en
Publisher:
Release Date : 1993-04-27
Growth Hormone And Insulin Like Growth Factor I In Human And Experimental Diabetes written by Allan Flyvbjerg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-27 with Health & Fitness categories.
Current research indicates that growth factors play a role in the physiological, metabolic, functional and structural changes seen in diabetes. This book combines the latest evidence regarding the effects of growth hormone and insulin-like growth factors in relation to metabolism in this disorder and the development of complications.
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System
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Author : Mohan Raizada
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System written by Mohan Raizada and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Nature categories.
Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.
Current Directions In Insulin Like Growth Factor Research
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Current Directions In Insulin Like Growth Factor Research written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.
The Growth Hormone Insulin Like Growth Factor Axis During Development
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Author : Isabel Varela-Nieto
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-17
The Growth Hormone Insulin Like Growth Factor Axis During Development written by Isabel Varela-Nieto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-17 with Medical categories.
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.