The Growth Hormone Insulin Like Growth Factor Axis During Development
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The Growth Hormone Insulin Like Growth Factor Axis During Development
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Author : Isabel Varela-Nieto
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-17
The Growth Hormone Insulin Like Growth Factor Axis During Development written by Isabel Varela-Nieto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-17 with Medical categories.
Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Pediatric Neuroendocrinology
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Author : Sandro Loche
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2010
Pediatric Neuroendocrinology written by Sandro Loche and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The neuroendocrine system plays a pivotal role in the control of growth, puberty, reproduction, and intermediate metabolism. This title presents the research on neuroendocrine physiology, advances in the control of the onset of puberty and its disorders, and basic and clinical aspects of the GH/IGF-1 and hypothalamic-pituitary-adrenal axes.
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Growth Hormone And Insulin Like Growth Factor I In Human And Experimental Diabetes
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Author : Allan Flyvbjerg
language : en
Publisher:
Release Date : 1993-04-27
Growth Hormone And Insulin Like Growth Factor I In Human And Experimental Diabetes written by Allan Flyvbjerg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-27 with Health & Fitness categories.
Current research indicates that growth factors play a role in the physiological, metabolic, functional and structural changes seen in diabetes. This book combines the latest evidence regarding the effects of growth hormone and insulin-like growth factors in relation to metabolism in this disorder and the development of complications.
Igf And Nutrition In Health And Disease
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Author : M. Sue Houston
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-08-04
Igf And Nutrition In Health And Disease written by M. Sue Houston and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-04 with Medical categories.
A benchmark review on how specific nutrients or adverse nutritional states impact the components of the IGF (Insulin-like Growth Factor) system and affect human health and disease. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, illuminate its essential role in physical development across the life span, and highlight the link between normal and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone, and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy.
Growth Hormone In Adults
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Author : Anders Juul
language : en
Publisher: Cambridge University Press
Release Date : 2000-04-27
Growth Hormone In Adults written by Anders Juul and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-04-27 with Medical categories.
This revised new edition reviews the substantial advances in our understanding of the vital role of growth hormone (GH) in maintaining adult health, and the resulting disorders from GH deficiency. The first edition, published in 1996, provided a pioneering overview of the subject; this new edition provides an even more comprehensive account, fully updated with the latest research, clinical applications, and references. The therapeutic benefits of GH treatment in GH deficiency are thoroughly evaluated, including effects on metabolism, cardiac function, exercise performance, psychosocial aspects, and aging and gender-specific effects. This compilation by the world's leading experts covers clinical investigation, diagnosis and treatment issues, and encompasses new knowledge of the control and action of GH secretion. This volume is the most authoritative, comprehensive, and detailed account available and will be an essential source of reference for all endocrinologists.
Insulin Like Growth Factor Receptor Signalling
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Insulin Like Growth Factor Receptor Signalling written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Medical categories.
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Advances In Growth Hormone And Growth Factor Research
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Author : Eugenio E. Müller
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Advances In Growth Hormone And Growth Factor Research written by Eugenio E. Müller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Medical categories.
Readers of this book can update their knowledge in the fast-moving field of endocrinology and neurobiology. Topics concerning growth and development are extensively reviewed from both basic science and clinical viewpoints. Aspects related to growth development and to the control of cellular differentiation and multiplication are discussed. Further new information is provided on: synthetic recombinant human growth hormone (rHGH); potential diagnostic and therapeutic applications of the neuropeptide, growth hormone releasing hormone (GHRH); the physiology and physiopathology of the neural control of growth hormone secretion; the diagnosis and therapy of growth hormone deficiency or excess states; and the biology, function and possible utilization of growth factors. These important new findings are relevant to progress in pediatrics, pediatric and clinical endocrinology, neuroendocrinology and physiology.
Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: CRC Press
Release Date : 1991-05-28
Insulin Like Growth Factors written by Derek LeRoith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-28 with Medical categories.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Current Directions In Insulin Like Growth Factor Research
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Current Directions In Insulin Like Growth Factor Research written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.