Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors
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Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Cellular Biology Of Insulin Like Growth Factors And Their Receptors written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
An essential element in the development and functional integrity of all organisms is intercellular communication. This is achieved by the secretion of soluble messenger molecules which subsequently interact with receptor-effector pathways in the responsive cells. Hormones are traditionally defined as chemical messengers synthesized by endocrine glands. Unlike hormones produced by endocrine glands, growth factors are hormone-related substances produced by many tissues and play an important role in controlling growth and development. While the exact physiological roles of growth factors have yet to be elucidated, they play important roles in the regulation of cellular proliferation and/or differentiation during ontogenesis, growth and differentiation. During recent years there has been a substantial increase in research related to peptide growth factors, their receptors, and modes of action. With the discovery and characterization of numerous growth factors, it became clear that these growth factors had multiple features in common with classic hormones as well as with oncogenes. Furthermore, there are distinct families of growth factors based either on structural or functional similarities.
Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: CRC Press
Release Date : 1991-05-28
Insulin Like Growth Factors written by Derek LeRoith and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-05-28 with Medical categories.
During the past decade, the continued interest in insulin-related growth factors has been documented by a plethora of research programs and publications focused on these growth factors. Both molecular and cellular biological techniques have improved and enabled investigators to study the properties of the growth factors in depth. This volume covers the molecular (genetic) aspects of the growth factors, their binding proteins and receptors, as well as those factors affecting their gene transcription and translation. In addition, aspects of the cellular action of these growth factors through their receptors and how this impacts normal cellular function are discussed. The book will provide valuable information for researchers in physiology, biology, endocrinology, and metabolism.
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology And Physiology Of Insulin And Insulin Like Growth Factors written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System
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Author : Mohan Raizada
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Insulin Insulin Like Growth Factors And Their Receptors In The Central Nervous System written by Mohan Raizada and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Nature categories.
Traditionally, intercellular communication and the regulation of biological functions of the body have been considered the role of two major and distinct systems: the nervous system and the endocrine system. The classic nervous system transmitted its signal rapidly by using electrical currents, whereas the signals used by the endocrine system were hormones produced by endocrine glands which reached the target tissues via the blood stream. During the past few decades, it has become apparent that these systems of intercellular com munication are not distinct and the signal messenger molecules are not unique to one or the other system. Many classic endocrine hormones are found in and act on nervous tissues and evidence exists for their de novo synthesis by neural related tissues. An exciting development in this area is the possibility that insulin and insulin-like growth factors (IGF) are not only produced by neural tissues but also exert profound physiological and biochemical effects on these tissues. The area of investigation of CNS insulin and IGF has been expanding rapidly and the availability of this book complete with up-to-date reviews on the subject by leaders in the field allows other scientists to utilize the knowledge in planning and adapting the latest ideas for future experiments. In addition, the book provides a collection of up-to-date articles for teachers to be used for the latest instructional material. The first section of the book covers general aspects of insulin receptors and insulin action.
Peptide Growth Factors And Their Receptors I
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Author : Michael B. Sporn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Peptide Growth Factors And Their Receptors I written by Michael B. Sporn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entire field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost impossible for anyone person to stay informed on this subject by reading the primary literature. At the same time it is becoming increasingly apparent that these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony stimulating factors," was quite artifactual; they are in fact the basis of a com mon language for intercellular communication. As a set they affect essentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research. This treatise is divided into four main sections. After three introductory chapters, its principal focus is the detailed description of each of the major peptide growth factors in 26 individual chapters.
Holland Frei Cancer Medicine
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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10
Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
The Insulin Like Growth Factors
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Author : Paul N. Schofield
language : en
Publisher:
Release Date : 1992
The Insulin Like Growth Factors written by Paul N. Schofield and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
The past decade has seen an explosion in our understanding of the factors regulating cell proliferation and differentiation. One of the most exciting advances has been the recognition of the pivotal role of the peptide growth factors in these processes. The insulin-like growth factors, discovered in 1958 by Salmon and Daughaday, are now among the best characterized growth factors. This comprehensive work describes the recent advances in knowledge of their receptors and binding proteins together with their purification and cloning. This provides exciting insights into the role of these factors in the physiology of normal growth, embryonic development and areas of pathology such as wound healing and cancer. In this book an international group of contributors reviews the most up-to-date information on all aspects of the insulin-like growth factors, and critically discusses models for IGF action in their own systems. The book is a valuable source of information and ideas for researchers, and an accessible introduction to the subject for students and clinicians.
Growth Factors And Their Receptors In Cancer Metastasis
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Author : Wen G. Jiang
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11
Growth Factors And Their Receptors In Cancer Metastasis written by Wen G. Jiang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Medical categories.
about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).
Insulin Like Growth Factors And Cancer
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Author : Derek LeRoith
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-18
Insulin Like Growth Factors And Cancer written by Derek LeRoith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-18 with Medical categories.
The book will detail the history, successes, and failures of targeted therapies for cancer, with a particular focus on IGF systems and cancer.
Insulin Like Growth Factor Receptor Signalling
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Author : Derek Leroith
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-07-31
Insulin Like Growth Factor Receptor Signalling written by Derek Leroith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-31 with Medical categories.
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.