Identifying The Key Pathogenic Factors Of Neurological Disorders By Integrating Multi Omics Data
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Identifying The Key Pathogenic Factors Of Neurological Disorders By Integrating Multi Omics Data
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Author : Andrea Legati
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-30
Identifying The Key Pathogenic Factors Of Neurological Disorders By Integrating Multi Omics Data written by Andrea Legati and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Ayurvedic Herbal Preparations In Neurological Disorders
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Author : Murali Muralidhara
language : en
Publisher: Elsevier
Release Date : 2023-08-07
Ayurvedic Herbal Preparations In Neurological Disorders written by Murali Muralidhara and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-07 with Medical categories.
Ayurvedic Herbal Preparations in Neurological Disorders provides a comprehensive and mechanistic understanding of the therapeutic potential of many ayurvedic herbal preparations in disease management. Examining research data for evidence-based ayurvedic approaches, this volume begins with a focused introduction to major ayurvedic plants, discussing various mechanisms underlying their neuromodulatory potential in preclinical and clinical settings. Major subsets of ayurvedic plants are discussed, including Bacopa monnieri, Centella asiatica, Withania somnifera, and others. This volume outlines the importance of integrative approaches along with existing treatments in the intervention/management of Alzheimer's disease, Parkinson's disease, depressive mood disorders, epilepsy, schizophrenia, and more. More than a mere compilation of studies, this volume identifies relevant gaps for future research avenues and encourages interdisciplinary collaboration and sharing of knowledge to together identify the most efficacious ayurvedic approaches. Highlighting recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection, this book is crucial for anyone researching or working in the field of neurological disorder treatment and prevention. - Provides a focused introduction to major Ayurvedic plants and their therapeutic potential in the management of neurodegenerative diseases - Discusses various mechanisms underlying the neuromodulatory potential of several ayurvedic herbal preparations in preclinical and clinical settings - Examines major subsets of ayurvedic plants (e.g., Bacopa monnieri, Centella asiatica, Withaniasomnifera, and others) and potential of several other plants in various neurological disorders - Outlines the importance of integrative approaches along with existing treatments in the intervention/management of depressive mood disorders, epilepsy, schizophrenia, and more - Highlights recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection
Congenital Brain Malformations
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Author : Khaled Fares AlAli
language : en
Publisher: Springer Nature
Release Date : 2024-05-21
Congenital Brain Malformations written by Khaled Fares AlAli and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-21 with Medical categories.
This book offers a clinical and surgical overview on congenital brain malformations, which are abnormalities that occur during fetal development, leading to brain defects and disorders. The fetal brain begins to develop shortly after conception and continues to grow throughout pregnancy. This book covers the various congenital brain malformations, their aetiologies and development, diagnosis and management including possible surgical interventions and details of these procedures. Since many of these disorders are rare, they do not have a final cure and their management is important - their consequences on the physical, psychological and developmental condition of the patient are great. This book is of interest to pediatric surgeons and neurologists.
Mapping Psychopathology With Mri And Connectivity Analysis
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Author : Long-Biao Cui
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-07
Mapping Psychopathology With Mri And Connectivity Analysis written by Long-Biao Cui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Science categories.
Bioinformatics Analysis Of Single Cell Sequencing And Multi Omics In The Aging And Age Associated Diseases
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Author : Shouneng Peng
language : en
Publisher: Frontiers Media SA
Release Date : 2024-03-13
Bioinformatics Analysis Of Single Cell Sequencing And Multi Omics In The Aging And Age Associated Diseases written by Shouneng Peng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-13 with Science categories.
Biological Insights Of Multi Omics Technologies In Human Diseases
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Author : Aarif Ali
language : en
Publisher: Elsevier
Release Date : 2024-05-23
Biological Insights Of Multi Omics Technologies In Human Diseases written by Aarif Ali and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-23 with Science categories.
"Biological Insights of Multi-Omics Technologies in Human Diseases ́ provides detailed information about the basics of multi-omic technologies including ethics, historical perspective, science, drug discovery, and development and metabolism. With a strong focus on the practical application of omics approaches in cancer, cardiovascular, neurology, respiratory, viral, gastroenterology, autoimmune diseases, PCOS and tuberculosis, this book also includes special topics related to COVID-19 and Machine learning approaches. In 13 chapters this book provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of multi-omics from academic, regulatory, pharmaceutical, socio-ethical, and economic perspectives. The chapters are designed in a well-defined chronology such that readers will intuitively understand the central idea. This book is an ideal resource for health professionals, scientists and researchers, nutritionists, health practitioners, students, and all those who wish to broaden their knowledge in the allied field. • Explains the in-depth role of multi-omics on drug discovery/metabolism, diseases, and highlights progress in both the research and clinical areas of computation, as well as relevant implementation experience and challenges. • Describes the practice of multi-omic technologies in the treatment of several diseases.• Includes practical application and machine learning approaches of multi-omics.
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases
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Author : Min Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases written by Min Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Oral Mucosal Immunity Homeostasis And Inflammation
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Author : Dunfang Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-03
Oral Mucosal Immunity Homeostasis And Inflammation written by Dunfang Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Medical categories.
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-06
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Medical categories.
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data
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Author : Fengfeng Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data written by Fengfeng Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.