Ige Based Cancer Immunotherapy
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Cancer And Ige
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Author : Manuel L. Penichet
language : en
Publisher: Springer Science & Business Media
Release Date : 2010
Cancer And Ige written by Manuel L. Penichet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Allergies are caused by a person's own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of IgE in cancer immunosurveillance. Is it thus possible that IgE immunoglobulins could have a beneficial function against cancer besides their harmful function in allergy? If so, can we exploit this beneficial function for the development of new cancer therapies? Could oncologists learn from allergists and vice versa? This book attempts to explore step by step these interesting questions, opening a novel science field: AllergoOncology. AllergoOncology by definition aims to reveal the function of IgE-mediated immune responses against cancer cells in order to enhance the understanding of its biology and to develop novel IgE-based treatment options against malignant diseases. Cancer and IgE: Introducing the Concept of AllergoOncology opens new avenues towards IgE antibodies as key effector molecules able to confer protection against cancer development and progression. This affinity-matured class of antibody, belonging to Th2-mediated immunity, uses an exquisite panel of potent effector cells which can eradicate malignant cells. Importantly, IgE is also capable of binding to professional antigen presenting cells thereby enhancing the presentation of cancer antigens and leading to a significant anti-tumor immune response. Based on its anti-tumor efficacy, which has been shown in vitro and in preclinical models, IgE can be potentially used in human in the context passive and active cancer immunotherapy. In summary, this book, which is the first of its class, is a comprehensive volume about the evolving new field AllergoOncology.
Ige Based Cancer Immunotherapy
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Author : Nataša Vuković
language : en
Publisher:
Release Date : 2022
Ige Based Cancer Immunotherapy written by Nataša Vuković and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Cancer And Ige
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Author : Manuel L. Penichet
language : en
Publisher: Humana Press
Release Date : 2010-03-04
Cancer And Ige written by Manuel L. Penichet and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-04 with Medical categories.
Erika Jensen-Jarolim and Manuel L. Penichet 1. 1 Background Infectious diseases, being the major burden in the history of mankind worldwide th until the beginning of the 20 century, were important triggers in the understanding of immunological mechanisms. In contrast to infectious diseases, reports of all- gies and cancers were less common, but increased tremendously within the last century. Based on the US mortality data of the National Center for Health Statistics, Centers for Disease Control and Prevention 2009, a recent report from the American Cancer Society indicated that the number of cancer deaths increased approximately from 100,000 to 550,000 per year between 1930 and 2006, paralleling the increase of the total population during this period. Leading causes of death from cancer are lung and bronchus cancer, in men prostate cancer, and in women breast c- cer [1, 2]. Normalization to population size shows that the cancer death rate for most malignancies has been generally stable, although the mortality rate of certain malignancies, such as lung and bronchus cancer, has increased over the last 50 years [1-3]. In allergy, the situation is less clear, because for the time period around the turn of th the 19 century, only imprecise information is available. However, within the last 30 years the incidences of allergies has doubled not only in industrial countries, but in developing countries as well [4].
Engineering Protein Based Modulators Of Allergic Temporal And Checkpoint Blockade Anti Cancer Immunity
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Author : Adrienne Marie Rothschilds
language : en
Publisher:
Release Date : 2019
Engineering Protein Based Modulators Of Allergic Temporal And Checkpoint Blockade Anti Cancer Immunity written by Adrienne Marie Rothschilds and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Effective cancer treatment of the future requires incorporating diverse and innovative aspects of immunity to fight against cancer, accounting for pharmacokinetic and temporal barriers of therapeutics, and engineering approaches to understand and improve upon current immunotherapies. This thesis addresses these challenges in three projects utilizing the Wittrup Lab's quantitative, engineering approach to protein-based cancer immunotherapy. In the first project, I attempted to harness the potency of allergic reactions against cancer by designing IgE class antibodies against two mouse tumor antigens and comparing them with traditional IgG antibodies. These IgE antibodies elicited modest or no tumor control, and limited efficacy could be due to fast pharmacokinetic clearance, absence of human-like allergic effector cells in mice, or tumor-suppressive effects from mast cells responding to IgE. The second project described in this thesis focused on synchronizing combination immunotherapies with the temporal progression of the anti-cancer immune response. In this work, anti-tumor antibodies were combined with the cytokines interleukin 2 (IL2) and interferon alpha (IFNa). The order of administration of these therapies decoupled strong efficacy from dose-limiting toxicity in two tumor models. Given before IFN[alpha], IL2 activated natural killer cells and heightened their responsiveness to subsequent IFN[alpha], which was ultimately toxic and unnecessary for therapeutic efficacy. This project's proof of concept that efficacy and toxicity could be unlinked in immunotherapy began to establish a framework to use for rational combination therapy treatment schedule design, with the goal of treating with each agent when that piece of the immune system is active. Finally, the third project used the Wittrup Lab's system of yeast surface display to engineer novel antibodies against the checkpoint blockade target cytotoxic T lymphocyte associated protein 4 (CTLA-4) as tools to improve understanding of the anti-CTLA-4 mechanism of action against cancer. Although the first wave of antibodies made had favorable characteristics against CTLA-4 as a soluble target, they bound a CTLA-4 epitope too close to the cell surface and so could not be used for therapeutic studies. Next generation sequencing on the yeast libraries identified alternative CTLA-4 binding antibody sequences, and these will be tested in future mechanistic and therapeutic studies.
Ige In Immunotherapy Of Cancer
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Author : Marguerite Bracher
language : en
Publisher:
Release Date : 2005
Ige In Immunotherapy Of Cancer written by Marguerite Bracher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Ige Antibodies Generation And Function
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Author : Juan J. Lafaille
language : en
Publisher: Springer
Release Date : 2015-01-02
Ige Antibodies Generation And Function written by Juan J. Lafaille and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-02 with Medical categories.
This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.
Oncoimmunology
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Author : Laurence Zitvogel
language : en
Publisher: Springer
Release Date : 2017-12-13
Oncoimmunology written by Laurence Zitvogel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-13 with Medical categories.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
The Basics Of Cancer Immunotherapy
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Author : Haidong Dong
language : en
Publisher: Springer Nature
Release Date :
The Basics Of Cancer Immunotherapy written by Haidong Dong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Cancer Immunotherapy Principles And Practice
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Author : Lisa H. Butterfield
language : en
Publisher:
Release Date : 2017
Cancer Immunotherapy Principles And Practice written by Lisa H. Butterfield and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Cancer categories.
Part 1: Intratumoral Signatures Associated With Immune Responsiveness
Fc Mediated Activity Of Antibodies
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Author : Jeffrey V. Ravetch
language : en
Publisher: Springer Nature
Release Date : 2019-09-03
Fc Mediated Activity Of Antibodies written by Jeffrey V. Ravetch and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with Medical categories.
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.