Imaging And Metabolism
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Imaging And Metabolism
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Author : Jason S. Lewis
language : en
Publisher: Springer
Release Date : 2017-09-25
Imaging And Metabolism written by Jason S. Lewis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-25 with Medical categories.
This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.
Exploring Cancer Metabolic Reprogramming Through Molecular Imaging
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Author : Franca Podo
language : en
Publisher: Frontiers Media SA
Release Date : 2017-07-27
Exploring Cancer Metabolic Reprogramming Through Molecular Imaging written by Franca Podo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-27 with Cancer categories.
The inclusion of oncogene-driven reprogramming of energy metabolism within the list of cancer hallmarks (Hanahan and Weinberg, Cell 2000, 2011) has provided major impetus to further investigate the existence of a much wider metabolic rewiring in cancer cells, which not only includes deregulated cellular bioenergetics, but also encompasses multiple links with a more comprehensive network of altered biochemical pathways. This network is currently held responsible for redirecting carbon and phosphorus fluxes through the biosynthesis of nucleotides, amino acids, lipids and phospholipids and for the production of second messengers essential to cancer cells growth, survival and invasiveness in the hostile tumor environment. The capability to develop such a concerted rewiring of biochemical pathways is a versatile tool adopted by cancer cells to counteract the host defense and eventually resist the attack of anticancer treatments. Integrated efforts elucidating key mechanisms underlying this complex cancer metabolic reprogramming have led to the identification of new signatures of malignancy that are providing a strong foundation for improving cancer diagnosis and monitoring tumor response to therapy using appropriate molecular imaging approaches. In particular, the recent evolution of positron emission tomography (PET), magnetic resonance spectroscopy (MRS), spectroscopic imaging (MRSI), functional MR imaging (fMRI) and optical imaging technologies, combined with complementary cellular imaging approaches, have created new ways to explore and monitor the effects of metabolic reprogramming in cancer at clinical and preclinical levels. Thus, the progress of high-tech engineering and molecular imaging technologies, combined with new generation genomic, proteomic and phosphoproteomic methods, can significantly improve the clinical effectiveness of image-based interventions in cancer and provide novel insights to design and validate new targeted therapies. The Frontiers in Oncology Research Topic “Exploring Cancer Metabolic Reprogramming Through Molecular Imaging” focusses on current achievements, challenges and needs in the application of molecular imaging methods to explore cancer metabolic reprogramming, and evaluate its potential impact on clinical decisions and patient outcome. A series of reviews and perspective articles, along with original research contributions on humans and on preclinical models have been concertedly included in the Topic to build an open forum on perspectives, present needs and future challenges of this cutting-edge research area.
Noninvasive Imaging Of Cardiac Metabolism
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Author : Ernst E. van der Wall
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Noninvasive Imaging Of Cardiac Metabolism written by Ernst E. van der Wall and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
F.J.Th. WACKERS Metabolic imaging: The future of cardiovascular nuclear imaging? Since cardiovascular nuclear imaging emerged as a new subspecialty in the mid-1970s, the field has gone through an explosive growth. Radionuclide techniques became readily recognized as important new diagnostic aids in the armamentarium of the clinical cardiologist. Initially, cardiovascular nuclear imaging focused on static myocardial imaging using either thallium-201 or technetium-99m-pyrophosphate for diagnosing acute myocardial infarction. Shortly thereafter, multigated equilibrium radionuclide angiocardiography became the most widely used noninvasive method for assessing cardiac function. Furthermore, attention and clinical application shifted towards the use of radionuclide techniques in conjunction with exercise testing, either with thallium-20 1 myocardial perfusion imaging or technetium-99m left ventricular function studies. The future of cardiovascular nuclear imaging appeared exciting and promising. However, around 1980 pessimists predicted the premature demise of cardiovascular nuclear imaging with the introduction of digital subtraction angiography and nuclear magnetic resonance imaging. These doomsayers have been proven wrong: in 1985 cardiovascular nuclear imaging is thriving and, in many centers, even expanding. Although digital substraction angiography and magnetic resonance imaging provided exquisite anatomic detail, for practical evaluation of patients with ischemic heart disease - in the Coronary Care Unit or exercise laboratory - nuclear techniques appeared to be more practical.
Advances In Metabolic Mapping Techniques For Brain Imaging Of Behavioral And Learning Functions
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Author : Francisco Gonzalez-Lima
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Advances In Metabolic Mapping Techniques For Brain Imaging Of Behavioral And Learning Functions written by Francisco Gonzalez-Lima and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities.
Optical Imaging Of Brain Function And Metabolism 2
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Author : Arno Villringer
language : en
Publisher:
Release Date : 2014-09-01
Optical Imaging Of Brain Function And Metabolism 2 written by Arno Villringer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-01 with categories.
Optical Imaging Of Brain Function And Metabolism 2
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Author : Arno Villringer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Optical Imaging Of Brain Function And Metabolism 2 written by Arno Villringer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
This volume covers the latest developments in optical imaging of the brain which is becoming an increasingly important functional neuroimaging method. Optical intrinsic signals offer unrivaled temporal and spatial resolution of functional measurements of the exposed brain cortex in animals and humans. Near-infrared spectroscopy and imaging ap proaches permit the noninvasive functional assessment of the human brain at bedside. Main advantages of these optical techniques are the biochemical specificity of the meas urements and the potential of measuring correlates of intracellular and intravascular oxy genation simultaneously. Recent data indicate that one may also measure a more direct correlate of neuronal activity associated with changes in light scattering. In this volume, recent technical progress of the optical method is covered as well as the physiological basis of the measurements. In simultaneous studies, near-infrared spec troscopy measurements are directly compared to other functional methods, especially PET and fMRI and examples are given for new applications of the NIRS-method. Based on re sults obtained with optical methods and other functional techniques the latest in our under standing of the coupling of neuronal activity and cerebral blood flow response is reviewed. This is an important basis for a better understanding of all functional neuroi maging methods which rely on neurovascular coupling such as PET, SPET and fMRI. Fi nally the optical method is put into the perspective of presently available functional neuroimaging methods including fMRI, PET, MEG and EEG.
Optical Imaging Of Brain Function And Metabolism
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Author :
language : en
Publisher:
Release Date : 19??
Optical Imaging Of Brain Function And Metabolism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.
Magnetic Resonance Spectroscopic Imaging Of Metabolism And Ph For Tumor Characterization In Vivo Using Hyperpolarized 13c Labelled Biosensors
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Author : Stephan Maximilian Düwel
language : en
Publisher:
Release Date : 2017
Magnetic Resonance Spectroscopic Imaging Of Metabolism And Ph For Tumor Characterization In Vivo Using Hyperpolarized 13c Labelled Biosensors written by Stephan Maximilian Düwel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Hyperpolarized Carbon 13 Magnetic Resonance Imaging And Spectroscopy
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Author : Peder Larson
language : en
Publisher: Academic Press
Release Date : 2021-11-28
Hyperpolarized Carbon 13 Magnetic Resonance Imaging And Spectroscopy written by Peder Larson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-28 with Psychology categories.
MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It’s primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis. Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology. Presents the physics and hardware of dissolution dynamic nuclear polarization Explains the behaviour of hyperpolarized carbon-13 agents and how to image them Detailed guidance on experimental design and data interpretation Identifies promising and potential applications of hyperpolarized carbon-13 MR
Imaging In Endocrinology
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Author : Paolo Pozzilli
language : en
Publisher: John Wiley & Sons
Release Date : 2014-01-07
Imaging In Endocrinology written by Paolo Pozzilli and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-07 with Medical categories.
Imaging in Endocrinology will provide endocrinologists and radiologists of all levels with an outstanding diagnostic imaging atlas to aid them in the diagnosis and management of all the major endocrine diseases they are likely to encounter. In full colour throughout, the 300 high-quality images consist of CT scans, MRI, NMR and histopathology slides, and are arranged by each specific endocrine condition, resulting in a visually outstanding and easily accessible tool that guides the user through exactly what to look out for and provides a practical and extremely useful aid in helping them formulate a diagnosis. Every major endocrine condition is covered in a specific section, including diseases of the thyroid, pituitary, reproductive and adrenal glands, the pancreas, bone metabolism problems, and the various forms of endocrine cancers. Each disease covered will offer a comparison of the normal findings so as to further assist in diagnosis. An accompanying website contains an online slide-atlas of all the figures in the book, to allow users to download all figures for use in presentations. Led by Paolo Pozzilli, an internationally-recognised expert in this field, the authors have assembled a wonderful collection of images that will be greatly valued by endocrinologists and radiologists alike, ensuring this is the perfect tool to consult when assessing patients with endocrine disease.