Imaging Biomarkers
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Imaging Biomarkers
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Author : Luis Martí-Bonmatí
language : en
Publisher: Springer
Release Date : 2016-11-03
Imaging Biomarkers written by Luis Martí-Bonmatí and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Medical categories.
This is the first book to cover all aspects of the development of imaging biomarkers and their integration into clinical practice, from the conceptual basis through to the technical aspects that need to be considered in order to ensure that medical imaging can serve as a powerful quantification instrument capable of providing valuable information on organ and tissue properties. The process of imaging biomarker development is considered step by step, covering proof of concept, proof of mechanism, image acquisition, image preparation, imaging biomarker analysis and measurement, detection of measurement biases (proof of principle), proof of efficacy and effectiveness, and reporting of results. Sources of uncertainty in the accuracy and precision of measurements and pearls and pitfalls in gold standards and biological correlation are discussed. In addition, practical use cases are included on imaging biomarker implementation in brain, oncologic, cardiovascular, musculoskeletal, and abdominal diseases. The authors are a multidisciplinary team of expert radiologists and engineers, and the book will be of value to all with an interest in the quantitative imaging of biomarkers in personalized medicine.
Imaging Biomarkers In Epilepsy
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Author : Andrea Bernasconi
language : en
Publisher: Cambridge University Press
Release Date : 2019-01-10
Imaging Biomarkers In Epilepsy written by Andrea Bernasconi and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Medical categories.
Assembles world-class expertise on clinical and molecular imaging-derived biomarkers, presenting neuroimaging in epilepsy in a broad neuroscientific context.
Diffusion Tensor Imaging And Fractional Anisotropy
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Author : Rahul P. Kotian
language : en
Publisher: Springer Nature
Release Date : 2022-11-03
Diffusion Tensor Imaging And Fractional Anisotropy written by Rahul P. Kotian and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-03 with Medical categories.
The book covers all aspects of one of the most advanced magnetic resonance imaging techniques, namely Diffusion Tensor Imaging (DTI) and Fractional Anisotropy (FA) values in early Parkinson’s disease (PD) patients. It provides step-by-step descriptions of DTI and its use in the early diagnosis of Parkinson’s disease by using FA values at several grey and white matter regions of the brain with helpful MRI DTI images. It includes clear flow charts with MRI DTI imaging protocol for Parkinson’s disease to aid in early diagnosis and treatment. The book covers essential information on anatomy and pathology in Parkinson’s disease and includes dedicated chapters on diffusion tensor imaging and FA in Parkinson’s disease. Additionally, it covers the role of magnetic resonance imaging in Parkinson’s disease with routine findings for Parkinson’s disease in MRI, followed by advanced imaging biomarkers and predictors in Parkinson’s disease. The book will assist the practitioners in the early detection of Parkinson’s disease using specific imaging biomarkers with the help of FA values, which will help in the early treatment of PD patients and thus extend and improve their quality of life. It will also be relevant for MD radiology, M.Sc. medical imaging technology students/trainees and Ph.D. medical imaging graduates as well as B.Sc MIT students.
Metabolic And Vascular Imaging Biomarkers For Brain Aging And Alzheimer S Disease
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Author : Ai-Ling Lin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-10
Metabolic And Vascular Imaging Biomarkers For Brain Aging And Alzheimer S Disease written by Ai-Ling Lin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with Science categories.
Functional And Molecular Imaging In Oncology An Issue Of Magnetic Resonance Imaging Clinics Of North America
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Author : Antonio Luna
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-01-19
Functional And Molecular Imaging In Oncology An Issue Of Magnetic Resonance Imaging Clinics Of North America written by Antonio Luna and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-19 with Medical categories.
This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!
Imaging Biomarkers Of Treatment Response
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Author :
language : en
Publisher:
Release Date : 2015
Imaging Biomarkers Of Treatment Response written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Quantitative imaging biomarkers -- numerical measurements derived from medical imaging that can be interpreted by clinicians - are a critical component of treatment response assessment in oncology. They can also play an important role in the design and interpretation of clinical trials, provided that they are measured following a standardized set of best practices. In this thesis, we have demonstrated the successful application of imaging biomarkers of treatment response to a clinical trial assessing the pharmacodynamics and pharmacokinetics of the anti-angiogenic TKI therapeutic Axitinib. We have illustrated the challenges facing quantitative imaging biomarkers in general, and gained valuable insights into anti-angiogenic therapy in particular. We have characterized the pharmacodynamics of "withdrawal flare," a rapid increase in tumor proliferation following cessation of anti-angiogenic therapy, using quantitative imaging biomarkers derived from FLT PET. This is the first time in humans that the temporal dynamics of Axitinib withdrawal flare have been characterized, a critical step in optimizing the use of this drug in combination therapy. Although we demonstrated that significant flare occurs in patients treated with Axitinib, we also observed substantial inter-patient heterogeneity in imaging response during withdrawal. Among the sub-set of patients experiencing withdrawal flare, it was found to occur at two days post-cessation of Axitinib, with relatively little additional flare between days 2 and 7 of withdrawal. Moreover, withdrawal flare was found to be associated with poor clinical outcome. We directly compared the results of the Axitinib trial with an earlier trial of a related anti-angiogenic drug, Sunitinib, which had used the same imaging biomarkers of treatment response. The proliferative and vascular response during withdrawal of Axitinib and Sunitinib was found to be nearly identical, and there is not sufficient evidence to support any significant difference in proliferative response during treatment. We also explored intra-patient, inter-lesion response heterogeneity. However, when comparing the imaging response with pre-treatment phenotypes, no significant correlations were observed, suggesting that some underlying biological mechanisms may be driving the inter-lesion differences in response. The insights gained from this original work support several hypotheses for how to improve patient treatment. These hypotheses will be partially addressed in three new ongoing clinical trials at the University of Wisconsin
Functional Imaging In Oncology
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Author : Antonio Luna
language : en
Publisher: Springer
Release Date : 2014-07-08
Functional Imaging In Oncology written by Antonio Luna and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
In the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including diffusion MRI, perfusion CT and MRI, dual-energy CT, spectroscopy, dynamic contrast-enhanced ultrasonography, PET, and hybrid modalities. This second volume considers the applications and benefits of these techniques in a wide range of tumor types, including their role in diagnosis, prediction of treatment outcome, and early evaluation of treatment response. Each chapter addresses a specific malignancy and is written by one or more acclaimed experts. The lucid text is complemented by numerous high-quality illustrations that highlight key features and major teaching points.
Handbook For Clinical Trials Of Imaging And Image Guided Interventions
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Author : Nancy A. Obuchowski
language : en
Publisher: John Wiley & Sons
Release Date : 2016-02-15
Handbook For Clinical Trials Of Imaging And Image Guided Interventions written by Nancy A. Obuchowski and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-15 with Medical categories.
Handbook for Clinical Trials of Imaging and Image-Guided Interventions is the first single-source, multi-disciplinary reference, based on the didactic sessions presented at the annual ‘Clinical Trials Methodology Workshop’ for radiologists, radiation oncologists and imaging scientists (sponsored by the Radiological Society of North America (RSNA)). It focuses on educating radiologists, radiation oncologists and those involved in imaging research with how to design and conduct clinical trials to evaluate imaging technology and imaging biomarkers. The internationally renowned contributors take a broad approach, starting with principles of technology assessment, and then move into specific topics covering the clinical trials of therapy and clinical research in imaging guided interventions including radiotherapy. They discuss the use of imaging as a predictor of therapeutic response, screening trial design, and the practicalities of how to run an efficient clinical trial and good working practices. Later chapters provide a comprehensive array of quantitative methods including: an introduction to statistical considerations in study design, biostatistical analysis methods and their role in clinical imaging research, methods for quantitative imaging biomarker studies, and an introduction to cost effectiveness analysis. Handbook for Clinical Trials of Imaging and Image-Guided Interventions will educate and prepare radiologists at all levels and in all capacities in planning and conducting clinical imaging trials.
Functional Imaging In Oncology
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Author : Antonio Luna
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Functional Imaging In Oncology written by Antonio Luna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
In the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This well-illustrated two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including preclinical and clinical imaging techniques, based on US, CT, MRI, PET and hybrid modalities. This first volume explains the biophysical basis for these functional imaging techniques and describes the techniques themselves. Detailed information is provided on the imaging of cancer hallmarks, including angiogenesis, tumor metabolism, and hypoxia. The techniques and their roles are then discussed individually, covering the full range of modalities in clinical use as well as new molecular and functional techniques. The value of a multiparametric approach is also carefully considered.
Advances And New Insights Into Cancer Characterization When Novel Imaging Meets Quantitative Imaging Biomarkers Vol Ii
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Author : Guang Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2023-04-27
Advances And New Insights Into Cancer Characterization When Novel Imaging Meets Quantitative Imaging Biomarkers Vol Ii written by Guang Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Medical categories.