Immunobiology Of Bacterial Cpg Dna
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Immunobiology Of Bacterial Cpg Dna
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Author : H. Wagner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunobiology Of Bacterial Cpg Dna written by H. Wagner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Immunobiology Of Bacterial Cpg Dna
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Author : H Wagner
language : en
Publisher:
Release Date : 1999-12-08
Immunobiology Of Bacterial Cpg Dna written by H Wagner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-08 with Antigen presenting cells categories.
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Microbial Dna And Host Immunity
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Author : Eyal Raz
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-09-26
Microbial Dna And Host Immunity written by Eyal Raz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-26 with Science categories.
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Immunostimulatory Dna Sequences
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Author : E. Raz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunostimulatory Dna Sequences written by E. Raz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume is a product of a collaborative effort and attempts to provide a wide and up-to-date coverage of information regarding the biology and on the potential application of immunostimulatory DNA. ISS hold great promise for influencing the immune response and the authors anticipate that the high efficacy and low toxicity observed in animal models will translate into success in a variety of human clinical applications.
Current Topics In Microbiology And Immunology
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Author : Hermann Wagner
language : de
Publisher:
Release Date : 1967
Current Topics In Microbiology And Immunology written by Hermann Wagner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Antigen presenting cells categories.
Bacterial CpG-DNA sequences not only serve for genetic information but act as "danger" signal to alert immune cells such as macrophages and dendritic cells. CpG-DNA directly causes activation of these members of the innate immune system yielding in up-regulation of co-stimulatory molecules and pro-inflammatory cytokines. As such they act as "natural" adjuvants to promote protective Th1 polarized T cell immune responses. This book is the first comprehensive review of the data emerging in this field.
Nucleic Acids In Innate Immunity
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Author : Ken J. Ishii
language : en
Publisher: CRC Press
Release Date : 2008-05-22
Nucleic Acids In Innate Immunity written by Ken J. Ishii and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-22 with Medical categories.
Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation
Microbial Dna And Host Immunity
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Author : Eyal Raz
language : en
Publisher:
Release Date : 2002-09-26
Microbial Dna And Host Immunity written by Eyal Raz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-26 with categories.
The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis). Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.
Cpg Dna Antigen Conjugates
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Author :
language : en
Publisher:
Release Date : 2006
Cpg Dna Antigen Conjugates written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Bacterial DNA as well as synthetic singlestranded CpG-DNA oligonucleotides displaying unmethylated CpG motifs activate the vertebrate immune system. Upon engaging toll-like receptor 9 CpG-DNA triggers potent Th1-based immune responses characterized by generation of cytotoxic T lymphocytes (CTL), certain cytokines and antibody subclasses. Here we demonstrate that by covalently linking antigen and CpG-DNA antigen is efficiently directed into intracellular compartments of antigen presenting cells resulting in activation, increased cross-presentation of antigen-derived peptides and thus enhanced induction of antigen-specific CTL responses in vivo. Hence, linked CpG-DNA fulfils a dual role: shutteling antigen-uptake and mediating antigen-specific activation. Since conjugation to stimulatory DNA reduces allergenicity, yet improves immunogenicity of complexed antigens, these conjugates could yield therapeutic potential in vaccine strategies against cancer, allergy or infectious diseases.
Toll Like Receptors Tlrs And Innate Immunity
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Author : Stefan Bauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-11
Toll Like Receptors Tlrs And Innate Immunity written by Stefan Bauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-11 with Medical categories.
Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
